Cardiovascular complications of sleep disorders: A better night’s sleep for a healthier heart / From bench to bedside

Journal article

Manolis, Theodora A., Manolis, Antonis A., Apostolopoulos, Evdoxia J., Melita, H. and Manolis, A. 2020. Cardiovascular complications of sleep disorders: A better night’s sleep for a healthier heart / From bench to bedside. Current Vascular Pharmacology. 19 (2), pp. 210-232. https://doi.org/10.2174/1570161118666200325102411
AuthorsManolis, Theodora A., Manolis, Antonis A., Apostolopoulos, Evdoxia J., Melita, H. and Manolis, A.
AbstractSleep is essential to and an integral part of life and when lacking or disrupted, a multitude of mental and physical pathologies ensue, including cardiovascular (CV) disease, which increases health care costs. Several prospective studies and meta-analyses show that insomnia, short (<7h) or long (>9h) sleep and other sleep disorders are associated with an increased risk of hypertension, metabolic syndrome, myocardial infarction, heart failure, arrhythmias, CV disease risk and/or mortality. The mechanisms by which insomnia and other sleep disorders lead to increased CV risk may encompass inflammatory, immunological, neuro-autonomic, endocrinological, genetic and microbiome perturbations. Guidelines are emerging that recommend a target of >7 h of sleep for all adults >18 years for optimal CV health. Treatment of sleep disorders includes cognitive-behavioral therapy considered the mainstay of non-pharmacologic management of chronic insomnia, and drug treatment with benzodiazepine receptor agonists binding to gamma aminobutyric acid type A (benzodiazepine and non-benzodiazepine agents) and some antidepressants. However, observational studies and meta-analyses indicate an increased mortality risk of anxiolytics and hypnotics, although bias may be involved due to confounding and high heterogeneity in these studies. Nevertheless, it seems that the risk incurred by the non-benzodiazepine hypnotic agents (Z drugs) may be relatively less than the risk of anxiolytics, with evidence indicating that at least one of these agents, zolpidem, may even confer a lower risk of mortality in adjusted models. All these issues are herein reviewed.
KeywordsPharmacology; Cardiology and cardiovascular medicine; Sleep; Sleep disorders
Year2020
JournalCurrent Vascular Pharmacology
Journal citation19 (2), pp. 210-232
PublisherBentham Science Publishers
ISSN1570-1611
Digital Object Identifier (DOI)https://doi.org/10.2174/1570161118666200325102411
Official URLhttps://www.eurekaselect.com/180497/article
Publication dates
Online30 Dec 2020
Print30 Dec 2020
Publication process dates
Deposited09 Aug 2021
Output statusPublished
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https://repository.canterbury.ac.uk/item/8y63q/cardiovascular-complications-of-sleep-disorders-a-better-night-s-sleep-for-a-healthier-heart-from-bench-to-bedside

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