Adaptations in cardiac structure and function following high intensity interval training in a physically inactive population

Masters Thesis

Bull, S. 2018. Adaptations in cardiac structure and function following high intensity interval training in a physically inactive population. Masters Thesis Canterbury Christ Church University Faculty of Education
AuthorsBull, S.
TypeMasters Thesis
Qualification nameMSc

Physical inactivity is associated with increased risk of cardiovascular disease and myocardial dysfunction. High intensity interval training (HIIT) has been shown to improve cardiovascular health; however, adaptations of cardiac structure and function are uncertain. Therefore, the aim of the present study was to analyse cardiac structural and functional adaptations to a HIIT protocol.

Forty-one physically inactive individuals (males n=20 and females n=21) were randomised into either a 4-week HIIT intervention or control group. The HIIT consisted of 3 x 30-second maximal cycle ergometer sprints against a resistance of 7.5% body weight, separated by 2-minute active recovery periods. In total, 12-sessions were performed. All cardiac structural and functional parameters were measured by quantitative 2D transthoracic echocardiography, performed using a commercially available, portable ultrasound system (Vivid‐q, GE Healthcare, Milwaukee, Wisconsin) with a 1.5–3.6 MHz phased array transducer (M4S‐RS Matrix cardiac ultrasound probe).

The HIIT intervention produced significant improvements in resting heart rate (65.59 ± 10.15 to 63.05 ± 13.42 b·min-1, P=0.013), stroke volume (55.48 ± 16.27 to 64.24 ± 20.62ml, P=0.015), left ventricular end diastolic volume (115.59 ± 28.34 to 131.94 ± 33.40ml, P=0.025), E/a ratio (1.98 ± 0.48 to 1.95 ± 0.55; P=0.027), average E/e’ ratio (5.41 ± 1.17 to 5.22 ± 0.89; P=0.002) and isovolumetric relaxation time (81.23 ± 12.85 to 77.83 ± 9.81 m·s-1; P=0.022) compared to the control group.

HIIT produced significant improvements in resting haemodynamics and diastolic function. This time efficient exercise intervention produces important improvements in myocardial function in a physically inactive population, which may be of clinical importance in higher risk populations.

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Publication process dates
Deposited11 Dec 2018
Output statusUnpublished
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