Genomic structure and cloning of two transcript isoforms of human Sp8.
Mylona, A., Gough, J. and Edgar, A. 2004. Genomic structure and cloning of two transcript isoforms of human Sp8. BMC Genomics. 5 (86). https://doi.org/10.1186/1471-2164-5-86
|Authors||Mylona, A., Gough, J. and Edgar, A.|
Background: The Specificity proteins (Sp) are a family of transcription factors that have three highly conserved zinc-fingers located towards the carboxy-terminal that bind GC-boxes and assist in the initiation of gene transcription. Human Sp1-7 genes have been characterized. Recently, the phenotype of Sp8 null mice has been described, being tailless and having severe truncation of both fore and hind limbs. They also have malformed brains with defective closure of the anterior and posterior neuropore during brain development.
|Journal citation||5 (86)|
|Digital Object Identifier (DOI)||https://doi.org/10.1186/1471-2164-5-86|
|Publication process dates|
|Deposited||09 Dec 2014|
|Accepted||08 Nov 2004|
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