Paradoxical post-exercise responses of acylated ghrelin and leptin during a simulated night shift

Journal article


Morris, C., Fullick, S., Gregson, W., Clarke, N., Doran, D., Maclaren, D. and Atkinson, G. 2010. Paradoxical post-exercise responses of acylated ghrelin and leptin during a simulated night shift. Chronobiology Int. The Journal of Biological & Medical Rhythm Research. 27 (3), pp. 590-605. https://doi.org/10.3109/07420521003663819
AuthorsMorris, C., Fullick, S., Gregson, W., Clarke, N., Doran, D., Maclaren, D. and Atkinson, G.
Abstract

Approximately 10% of employees undertake night-work which is a significant predictor of weight-gain, possibly because responses to activity and eating are altered at night. It is known that the appetite-related hormone, acylated ghrelin is suppressed after an acute bout of exercise during the day, but no researcher has explored whether evening exercise alters acylated ghrelin and other appetite-related outcomes during a subsequent night-shift. Six healthy men (mean±SD: age 30±8 yrs, body mass index 23.1±1.1 kg/m2) completed two crossover trials (control and exercise) in a random order. Participants fasted from 10:00 h, consumed a test meal at 18:00 h and then cycled at 50% peak oxygen uptake or rested between 19:00-20:00 h. Participants then completed light activities during a simulated night-shift which ended at 05:00 h. Two small isocaloric meals were consumed at 22:00 and 02:00 h. Venous blood samples were drawn via cannulation at 1-h intervals between 19:00-05:00 h for the determination of acylated ghrelin, leptin, insulin, glucose, triglyceride and non-esterified fatty acids concentrations. Perceived hunger and wrist actimetry were also recorded. During the night-shift, mean±SD acylated ghrelin concentration was 86.5±40.8 pg/ml following exercise compared with 71.7±37.7 pg/ml without prior exercise (P=0.015). Throughout the night-shift, leptin concentration was 263±242 pg/ml following exercise compared with 187±221 pg/ml without prior exercise (P=0.017). Mean levels of insulin, triglyceride, non-esterified fatty acids and wrist actimetry were also higher during the night-shift that followed exercise (P<0.05). These data indicate that prior exercise increases acylated ghrelin and leptin concentrations during a subsequent simulated night-shift. These findings differ from the known effects of exercise on acylated ghrelin and leptin during the day, and therefore have implications for energy balance during night-work.

Year2010
JournalChronobiology Int. The Journal of Biological & Medical Rhythm Research
Journal citation27 (3), pp. 590-605
PublisherMarcel Dekker
ISSN1525-6073
Digital Object Identifier (DOI)https://doi.org/10.3109/07420521003663819
FunderNational Prevention Research Initiative (http://www.npri.org.uk): Medical Research Council : G0501286(75373)
Publication process dates
Deposited05 Jun 2017
Accepted2010
Output statusPublished
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https://repository.canterbury.ac.uk/item/882x3/paradoxical-post-exercise-responses-of-acylated-ghrelin-and-leptin-during-a-simulated-night-shift

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