Dr Marieke Bloemink
| Name | Dr Marieke Bloemink |
|---|---|
| Job title | Senior Lecturer |
| Research institute | School of Psychology and Life Sciences |
Research outputs
Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation
Tumbapo, Sobha, Strudwick, Adam, Stastna, Jana J., Harvey, Simon C. and Bloemink, Marieke J. 2024. Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation. Mechanisms of Ageing and Development. 217, p. 111900. https://doi.org/10.1016/j.mad.2023.111900Effect of caloric restriction and omega-3 EPA supplementation on sarcopenia in C. elegans
Tumbapo, S., Strudwick, A., Stastna, J., Harvey, S. and Bloemink, M. 2022. Effect of caloric restriction and omega-3 EPA supplementation on sarcopenia in C. elegans.Marine microplastics: an assessment of the North Kent coastline
Bloemink, M., Farrell-Silk, K and Cussen, E. 2021. Marine microplastics: an assessment of the North Kent coastline.Dietary intervention delays the onset of Sarcopenia in Caenorhabditis elegans
Tumbapo, S., Strudwick, A., Stastna, J., Harvey, S. and Bloemink, M. 2021. Dietary intervention delays the onset of Sarcopenia in Caenorhabditis elegans.Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain
Bloemink, M.J., Hsu, K.H., Geeves, M.A. and Bernstein, S.I. 2020. Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain. The Journal of Biological Chemistry. https://doi.org/10.1074/jbc.RA120.014684The most prevalent Freeman-Sheldon Syndrome mutations in the embryonic myosin motor share functional defects
Walklate, J., Vera, C., Bloemink, M., Geeves, M. and Leinwand, L. 2016. The most prevalent Freeman-Sheldon Syndrome mutations in the embryonic myosin motor share functional defects. The Journal of Biological Chemistry. 291, pp. 10318-10331. https://doi.org/10.1074/jbc.M115.707489The relay-converter interface influences hydrolysis of ATP by skeletal muscle myosin II
Bloemink, M., Melkani, G., Bernstein, S. and Geeves, M. 2015. The relay-converter interface influences hydrolysis of ATP by skeletal muscle myosin II. The Journal of Biological Chemistry.The hypertrophic cardiomyopathy myosin mutation R453C alters ATP-binding and hydrolysis of human cardiac beta-myosin.
Bloemink, M., Deacon, J., Langer, S., Vera, C., Combs, A., Leindwand, L. and Geeves, M. 2014. The hypertrophic cardiomyopathy myosin mutation R453C alters ATP-binding and hydrolysis of human cardiac beta-myosin. The Journal of Biological Chemistry. 289 (8), pp. 5158-5167. https://doi.org/10.1074/jbc.M113.511204Platinum containing compound, process for its preparation, and application of such compounds
Van den Berg, F., Lempers, E., Bloemink, M. and Reedijk, J. 1992. Platinum containing compound, process for its preparation, and application of such compounds.Methods for the production of platinum based linkers between labels and bio organic molecules, for labeling bio organic molecules, for detecting biological substances of interest and diagnostic test kits
Houthoff, H., Reedijk, J., Jelsma, T., Van Es, R., Van den Berg, F., Lempers, E. and Bloemink, M. 1996. Methods for the production of platinum based linkers between labels and bio organic molecules, for labeling bio organic molecules, for detecting biological substances of interest and diagnostic test kits.The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb and Hd isoforms
Bloemink, M., Deacon, J., Resnicow, D., Leinwand, L. and Geeves, M. 2013. The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb and Hd isoforms. The Journal of Biological Chemistry. 288 (38), pp. 27469-27479. https://doi.org/10.1074/jbc.M113.488130Identification of functional differences between recombinant human α and β cardiac myosin motors
Bloemink, M., Deacon, J., Rezavandi, H., Leinwand, L. and Geeves, M. 2012. Identification of functional differences between recombinant human α and β cardiac myosin motors. Cellular and Molecular Life Sciences (CMLS). 69 (24), pp. 4239-4255. https://doi.org/10.1007/s00018-012-0927-3Shaking the myosin family tree: biochemical kinetics defines four types of myosin motor
Bloemink, M. and Geeves, M. 2011. Shaking the myosin family tree: biochemical kinetics defines four types of myosin motor. Seminars in Cell and Developmental Biology. 22 (9), pp. 961-967. https://doi.org/10.1016/j.semcdb.2011.09.015Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities
Bloemink, M., Melkani, G., Dambacher, C., Bernstein, S. and Geeves, M. 2011. Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities. The Journal of Biological Chemistry. 286 (32), pp. 28435-28443. https://doi.org/10.1074/jbc.M111.258228Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head
Bloemink, M., Dambacher, C., Knowles, A., Melanki, G., Geeves, M. and Bernstein, S. 2009. Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head. Molecular Biology. 389 (4), pp. 707-721. https://doi.org/10.1016/j.jmb.2009.04.036Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin
Albet-Torres, N., Bloemink, M., Barman, T., Candau, R., Frolander, K., Geeves, M., Golker, K., Herrmann, C., Lionne, C., Piperio, C., Schmitz, S., Veigel, C. and Mansson, A. 2009. Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin. The Journal of Biological Chemistry. 284 (34), pp. 22926-22937. https://doi.org/10.1074/jbc.M109.019232Kinetic analysis of the slow skeletal myosin MHC-1 isoform from bovine masseter muscle
Bloemink, M., Adamek, N., Reggiani, C. and Geeves, M. 2007. Kinetic analysis of the slow skeletal myosin MHC-1 isoform from bovine masseter muscle. Journal of Molecular Biology. 373 (5), pp. 1184-1197. https://doi.org/10.1016/j.jmb.2007.08.050A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites
Miller, B., Bloemink, M., Nyitrai, M., Bernstein, S. and Geeves, M. 2007. A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites. Journal of Molecular Biology. 368 (4), pp. 1051-1066. https://doi.org/10.1016/j.jmb.2007.02.042Kinetic and mechanistic basis of the nonprocessive kinesin-3 motor NcKin3
Adio, S., Bloemink, M., Hartel, M., Leier, S., Geeves, M. and Woehlke, G. 2006. Kinetic and mechanistic basis of the nonprocessive kinesin-3 motor NcKin3. The Journal of Biological Chemistry. 281, pp. 37782-37793. https://doi.org/10.1074/jbc.M605061200Targeting retroviral Zn Finger-DNA interactions: a small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds
Anzellotti, A., Liu, Q., Bloemink, M., Scarsdale, J. and Farrell, N. 2006. Targeting retroviral Zn Finger-DNA interactions: a small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds. Journal of Chemistry and Biology. 13 (5), pp. 539-548. https://doi.org/10.1016/j.chembiol.2006.04.004Solution structure of the mycobacterium tuberculosis complex protein MPB70. From tuberculosis pathogenesis to inherited human corneal disease
Bloemink, M., Carr, M., Dentten, E., Whelan, A., Gordon, S., Kelly, G., Frenkiel, T., Hewinson, R. and Williamson, R. 2003. Solution structure of the mycobacterium tuberculosis complex protein MPB70. From tuberculosis pathogenesis to inherited human corneal disease. The Journal of Biological Chemistry. 278, pp. 43736-43743. https://doi.org/10.1074/jbc.M307235200Sequence-specific assignment and determination of the secondary structure of the 163-residue M. tuberculosis and M. bovis antigenic protein MPB70
Bloemink, M., Kemmink, J., Dentten, E., Muskett, F., Whelan, A., Sheikh, A., Hewinson, G., Williamson, R. and Carr, M. 2001. Sequence-specific assignment and determination of the secondary structure of the 163-residue M. tuberculosis and M. bovis antigenic protein MPB70. Journal of Biomolecular NMR. 20 (2), pp. 185-186.Phosphorylation of ribosomal protein L18 is required for its folding and binding to 5S rRNA
Bloemink, M. and Moore, P. 1999. Phosphorylation of ribosomal protein L18 is required for its folding and binding to 5S rRNA. Biochemistry. 38 (40), pp. 13385-13390. https://doi.org/10.1021/bi9914816Synthesis, crystal structure, antitumor activity and DNA binding properties of the new active platinum compound (bis(N methylimidazol 2 yl)-carbinol)dichloroplatinum(II), lacking a NH moiety, and of the inactive analog dichloro(N1,N1' dimethyl 2,2'biimidazole)platinum(II)
Bloemink, M., Engelking, H., Gutschow, N., Karenzoupoulos, N., Krebs, S. and Reedijk, J. 1996. Synthesis, crystal structure, antitumor activity and DNA binding properties of the new active platinum compound (bis(N methylimidazol 2 yl)-carbinol)dichloroplatinum(II), lacking a NH moiety, and of the inactive analog dichloro(N1,N1' dimethyl 2,2'biimidazole)platinum(II). Inorganic Chemistry. 35 (3), pp. 619-627. https://doi.org/10.1021/ic950584jDinuclear platinum complexes form a novel intrastrand adduct with d(GpG): an anti syn conformation of the macrochelate as observed by NMR and molecular modelling
Qu, Y., Bloemink, M., Reedijk, J., Hambley, T. and Farrell, N. 1996. Dinuclear platinum complexes form a novel intrastrand adduct with d(GpG): an anti syn conformation of the macrochelate as observed by NMR and molecular modelling. Journal of the American Chemical Society. 118 (39), pp. 9307-9313. https://doi.org/10.1021/ja961823kNew antitumor compounds linked to aminophosphonic acids loose the phosphonate and tertiary amine ligand upon binding to nucleic acids
Bloemink, M., Dorenbos, J., Heetebrij, R., Keppler, B., Reedijk, J. and Zahn, H. 1994. New antitumor compounds linked to aminophosphonic acids loose the phosphonate and tertiary amine ligand upon binding to nucleic acids. Inorganic Chemistry. 33 (6), pp. 1127-1132. https://doi.org/10.1021/ic00084a026Reactions of unsymmetrically substituted derivatives of cisplatin with short oligodeoxynucleotides containing a -GpG- sequence: H-bonding interactions in pGpG moieties cross-linked by an asymmetric platinum complex enhancing the formation of one geometrical isomer
Bloemink, M., Inagaki, K., Kidani, Y. and Reedijk, J. 1992. Reactions of unsymmetrically substituted derivatives of cisplatin with short oligodeoxynucleotides containing a -GpG- sequence: H-bonding interactions in pGpG moieties cross-linked by an asymmetric platinum complex enhancing the formation of one geometrical isomer. Inorganic Chemistry. 31 (22), pp. 4656-4661. https://doi.org/10.1021/ic00048a038The dinuclear complex [{trans PtCl(NH3)2}2{m H2N(CH2)6NH2}]Cl2 forms an unique macrochelate intrastrand crosslink with d(GpG)
Bloemink, M., Reedijk, J., Farrell, N., Qu, Y. and Stetsenko, A. 1992. The dinuclear complex [{trans PtCl(NH3)2}2{m H2N(CH2)6NH2}]Cl2 forms an unique macrochelate intrastrand crosslink with d(GpG). Journal of the Chemistry Society, Chemical Communications. https://doi.org/10.1039/C39920001002Reaction products of [Pt(ethylenediamine)(DMSO)Cl]Cl and [Pt(ethylenediamine)Cl2] with d(GpG) and 5'GMP. Unambiguous evidence for stable 1:1 intermediate N7 adducts with coordinated DMSO
Lempers, E., Bloemink, M. and Reedijk, J. 1991. Reaction products of [Pt(ethylenediamine)(DMSO)Cl]Cl and [Pt(ethylenediamine)Cl2] with d(GpG) and 5'GMP. Unambiguous evidence for stable 1:1 intermediate N7 adducts with coordinated DMSO. Inorganic Chemistry. 30 (2), pp. 201-206. https://doi.org/10.1021/ic00002a0121159
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