Dr Lee Byrne

NameDr Lee Byrne
Job titleSenior Lecturer
Research instituteSchool of Psychology and Life Sciences

Research outputs

Integrating research and knowledge exchange in the Science Undergraduate Curriculum: embedding employability through research-involved teaching

Harvey, C., Bertolo-Pardo, E. and Byrne, L. 2017. Integrating research and knowledge exchange in the Science Undergraduate Curriculum: embedding employability through research-involved teaching. in: Renes, S. (ed.) Global Voices in Higher Education In-Tech. pp. 111-128

Does co-transcriptional regulation of alternative splicing mediate plant stress responses?

Jabre, I., Reddy, A., Kalyna, M., Chaudhary, S., Khokhar, W., Byrne, L., Wilson, C. and Syed, N. 2019. Does co-transcriptional regulation of alternative splicing mediate plant stress responses? Nucleic Acids Research. 47 (6), pp. 2716-2726. https://doi.org/10.1093/nar/gkz121

Genome-wide identification of splicing quantitative trait loci (sQTLs) in diverse ecotypes of Arabidopsis thaliana

Khokhar, W., Hassan, M., Reddy, A., Chaudhary, S., Jabre, I., Byrne, L. and Syed, N. 2019. Genome-wide identification of splicing quantitative trait loci (sQTLs) in diverse ecotypes of Arabidopsis thaliana. Frontiers in Plant Science. 10 (1160). https://doi.org/10.3389/fpls.2019.01160

Alternative splicing and protein diversity: plants versus animals

Chaudhry, S., Khokhar, W., Jabre, I., Reddy, A., Byrne, L., Wilson, C. and Syed, N. 2019. Alternative splicing and protein diversity: plants versus animals. Frontiers in Plant Science. 10 (708). https://doi.org/10.3389/fpls.2019.00708

‘Something in the way she moves’: The functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI)

Freedman, R., Desmond, J., Byrne, L., Heal, J., Howard, M., Sanghera, N., Walker, K., Wallis, A., Wells, S., Williamson, R. and Romer, R. 2017. ‘Something in the way she moves’: The functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1865 (11 (A)), pp. 1383-1394. https://doi.org/10.1016/j.bbapap.2017.08.014

Winter Aconite (Eranthis hyemalis) Lectin as a cytotoxic effector in the lifecycle of Caenorhabditis elegans

McConnell, M., Lisgarten, D., Byrne, L., Harvey, S. and Bertolo-Pardo, E. 2015. Winter Aconite (Eranthis hyemalis) Lectin as a cytotoxic effector in the lifecycle of Caenorhabditis elegans. PeerJ. https://doi.org/10.7717/peerj.1206

Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochloride

Byrne, L., Cox, B., Coleman, D., Ridout, M., Morgan, B. and Tuiteq, M. 2007. Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochloride. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 104 (28), pp. 11688-11693. https://doi.org/10.1073/pnas.0701392104

The number and transmission of [PSI+] prion seeds (Propagons) in the yeast Saccharomyces cerevisiae

Byrne, L., Cole, D., Cox, B., Ridout, M., Morgan, B. and Tuite, M. 2009. The number and transmission of [PSI+] prion seeds (Propagons) in the yeast Saccharomyces cerevisiae. PLoS ONE. 4 (3), p. e4670. https://doi.org/10.1371/journal.pone.0004670

Mapping of the ligand-binding site on the b′ domain of human PDI: interaction with peptide ligands and the x-linker region

Byrne, L., Sidhu, A., Wallis, A., Ruddock, L., Freedman, R., Howard, M. and Williamson, R. 2009. Mapping of the ligand-binding site on the b′ domain of human PDI: interaction with peptide ligands and the x-linker region. Biochemical Journal. 423 (2), pp. 209-217. https://doi.org/10.1042/BJ20090565

The ligand-binding b' domain of human protein disulphide-isomerase mediates homodimerization

Wallis, A., Sidhu, A., Byrne, L., Howard, M., Ruddock, L., Williamson, R. and Freedman, R. 2009. The ligand-binding b' domain of human protein disulphide-isomerase mediates homodimerization. Protein Science. 18 (12), pp. 2569-2577. https://doi.org/10.1002/pro.270

AI is a viable alternative to high throughput screening: a 318-target study

Wilson, C.M., Byrne, L., Al-Yozbaki, M. and The Atomwise AIMS Program 2024. AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports. https://doi.org/10.1038/s41598-024-54655-z

Investigating the effect of silica nanoparticles as a drug delivery system for Doxorubicin in the treatment of lung cancer

Holder, J., Wilson, C., Bertolo-Pardo, E., Byrne, L., Oliveira, E., Lodeiro, C. and Trim, C. 2024. Investigating the effect of silica nanoparticles as a drug delivery system for Doxorubicin in the treatment of lung cancer.

Investigating the effect of mesoporous silica nanoparticles as a drug delivery system for Withaferin A in the treatment of Lung Cancer

Holder, J., Wilson, C., Bertolo-Pardo, E., Byrne, L., Lodeiro, C., Oliveira, E. and Trim, C. 2024. Investigating the effect of mesoporous silica nanoparticles as a drug delivery system for Withaferin A in the treatment of Lung Cancer.

The use of nanoparticles for targeted drug delivery in non-small cell lung cancer.

Holder, Jessica E, Ferguson, C., Oliveira, Elisabete, Lodeiro, Carlos, Trim, Carol M, Byrne, Lee J, Bertolo, Emilia and Wilson, Cornelia M 2023. The use of nanoparticles for targeted drug delivery in non-small cell lung cancer. Frontiers in Oncology. 13, p. 1154318. https://doi.org/10.3389/fonc.2023.1154318

Extracellular vesicles, stem cells and the role of miRNAs in neurodegeneration

Belkozhayev, Ayaz M., Al-Yozbaki, Minnatallah, George, Alex, Ye Niyazova, Raigul, Sharipov, Kamalidin O., Byrne, Lee J. and Wilson, Cornelia M. 2021. Extracellular vesicles, stem cells and the role of miRNAs in neurodegeneration. Current Neuropharmacology. 20 (8), pp. 1450-1478. https://doi.org/10.2174/1570159x19666210817150141

Utilisation of compounds from venoms in drug discovery

Trim, Carol M, Byrne, Lee J and Trim, Steven A 2021. Utilisation of compounds from venoms in drug discovery. Progress in Medicinal Chemistry. 60, pp. 1-66. https://doi.org/S0079-6468(21)00001-1
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