Institute of Medical Sciences


TypeSchool
FacultyFaculty of Medicine, Health and Social Care
Head of Academic SchoolDr Susan Plummer

Latest research outputs

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Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway.
Moon, Jeonghyeon, Cho, Keun-Hyung, Jhun, JooYeon, Choi, JeongWon, Na, Hyun-Sik, Lee, Jeong Su, Lee, Seung Yoon, Min, Jun-Ki, Shetty, Anan, Park, Sung-Hwan, Kim, Seok Jung and Cho, Mi-La 2024. Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway. Arthritis research & therapy. 26 (1), p. 199.

Journal article

Effect of facial fillers on post-rhinoplasty oedema- a hypothesis based on literature review.
Al Maamari, Salwa, Vansteelant, G., Appan, Shirrushtii and D'Souza, Alwyn Ray 2024. Effect of facial fillers on post-rhinoplasty oedema- a hypothesis based on literature review. Facial Plastic Surgery. https://doi.org/10.1055/a-2466-1407

Journal article

An international survey of the diagnosis and management of Ménière's disease amongst otolaryngology consultants
Koumpa, Foteini-Stefania, Parihar, Shivani, Neumann, Codruta, Ovnat Tamir, Sharon, Galera Ruiz, Hugo, Brunet, Aina, Fenton, John E, Korres, George, Praetorius, Mark and Kanegaonkar, Rahul G 2024. An international survey of the diagnosis and management of Ménière's disease amongst otolaryngology consultants. The Journal of International Advanced Otology. 20 (5), pp. 411-416. https://doi.org/10.5152/iao.2024.231469

Journal article

Assessing the quality and readability of online patient information: ENT UK patient information e-leaflets versus responses by a generative artificial intelligence
Shamil, E., Ko, Tsz Ki, Fan, K., Schuster-Bruce, James, Jaafar, Mustafa, Khwaja, Sadie, Eynon-Lewis, Nicholas, D'Souza, Alwyn and Andrews, Peter 2024. Assessing the quality and readability of online patient information: ENT UK patient information e-leaflets versus responses by a generative artificial intelligence. Facial Plastic Surgery. https://doi.org/10.1055/a-2413-3675

Journal article

The potential impact of universal screening for vasa previa in the prevention of stillbirths
Zhang, Weiyu, Oyelese, Y., Javinani, A., Shamshirsaz, Alireza and Akolekar, Ranjit 2024. The potential impact of universal screening for vasa previa in the prevention of stillbirths. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2024-0203

Journal article

Development of a core domain set for nailfold capillaroscopy reporting.
El Miedany, Yasser, Ismail, Sherif, Wadie, Mary, Müller-Ladneru, Ulf, Giacomelli, Roberto, Liakouli, Vasiliki, Hermann, Walter, Fathy, Nihal, El Gaafary, Maha, Fouad, Nermin A, Saber, Sally and Abu-Zaid, Mohamed Hassan 2024. Development of a core domain set for nailfold capillaroscopy reporting. Reumatologia clinica. 20 (7), pp. 345-352. https://doi.org/10.1016/j.reumae.2024.07.003

Journal article

Cost awareness of anaesthetic consumable items among the National Health Service (NHS) staff and the financial impact on the NHS
Divekar, Omkaar, Kumar, Abhinav, Divekar, Nandita and Kanegaonkar, Rahul 2024. Cost awareness of anaesthetic consumable items among the National Health Service (NHS) staff and the financial impact on the NHS. Cureus. 16 (7), p. e63906. https://doi.org/10.7759/cureus.63906

Journal article

A survey of the estimated cost of surgical consumable items within trauma and orthopaedic departments
Divekar, Omkaar, Pandya, Krushi, Divekar, Anand B. and Kanegaonkar, Rahul 2024. A survey of the estimated cost of surgical consumable items within trauma and orthopaedic departments. Cureus. 16 (7), p. e63793. https://doi.org/10.7759/cureus.63793

Journal article

Oxidized LDL accelerates cartilage destruction and inflammatory chondrocyte death in osteoarthritis by disrupting the TFEB-regulated autophagy-lysosome pathway
Lee, J., Kim, Y., Jhun, J., Na, H., Um, In Gyu, Choi, J., Woo, J., Kim, S., Shetty, A., Kim, S. and Cho, M. 2024. Oxidized LDL accelerates cartilage destruction and inflammatory chondrocyte death in osteoarthritis by disrupting the TFEB-regulated autophagy-lysosome pathway. Immune Network. 24 (3). https://doi.org/10.4110/in.2024.24.e15

Journal article

Graves' ophthalmopathy: the clinical and psychosocial outcomes of different medical interventions - a systematic review.
Bello, Oyinola Maria, Druce, Maralyn and Ansari, Ejaz 2024. Graves' ophthalmopathy: the clinical and psychosocial outcomes of different medical interventions - a systematic review. BMJ open ophthalmology. 9 (1), p. e001515. https://doi.org/10.1136/bmjophth-2023-001515

Journal article

“Comprehensive Rhinoplasty: Structural and Preservation Concepts” by Sam P. Most
Vansteelant, Géraldine and D'Souza, Alwyn Ray 2024. “Comprehensive Rhinoplasty: Structural and Preservation Concepts” by Sam P. Most. Facial Plastic Surgery. 40 (06), pp. 803-804. https://doi.org/10.1055/s-0044-1786186

Journal article

Blood pressure cut-offs at 11-13 weeks’ gestation and risk of preeclampsia
Slade, L., Syngelacki, Argyro, Wilson, Milly, Mistry, Hiten D., Akolekar, Ranjit, Von Dadelszen, Peter, Nicolaides, Kypros H. and Magee, L. 2024. Blood pressure cut-offs at 11-13 weeks’ gestation and risk of preeclampsia. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2024.04.032

Journal article

Defining criteria for disease activity states in systemic juvenile idiopathic arthritis based on the systemic Juvenile Arthritis Disease Activity Score
Rosina, Silvia, Rebollo‐Gimenez, Ana I., Tarantola, Letizia, Pistorio, Angela, Vyzhga, Y., El Miedany, Yasser, Lotfy, Hala M., Abu‐Shady, Hend, Eissa, M., Osman, Naglaa S., Hassan, Waleed, Mahgoub, Marwa Y., Fouad, Nermeen A., Mosa, D., Adel, Yasmin, Mohamed, Sheren E. M., Radwan, Ahmed R., Abu-Zaid, M., Tabra, Samar A. A., Shalaby, Radwa H., Nasef, S., Khubchandani, Raju, Khan, A., Maldar, Naziya P., Ozen, S., Bayindir, Yagmur, Alsuweiti, Motasem, Alzyoud, Raed, Almaaitah, Hiba, Vilaiyuk, Soamarat, Lerkvaleekul, Butsabong, Alexeeva, Ekaterina, Dvoryakovskaya, Tatyana, Kriulin, Ivan, Bracaglia, C., Pardeo, M., De Benedetti, F., Licciardi, F., Montin, Davide, Robasto, Francesca, Minoia, F., Filocamo, Giovanni, Rossano, Martina, Simonini, Gabriele, Marrani, Edoardo, Abu‐Rumeleih, S., Kostik, M., Belozerov, Konstantin E., Pal, P., Bathia, Jigna N., Katsicas, María M., Villarreal, Giselle, Marino, Achille, Costi, Stefania, Sztajnbok, Flavio, Silva, Rodrigo M., Maggio, Maria C., El‐Ghoneimy, Dalia H., El Owaidy, R., Civino, Adele, Diomeda, Federico, Al‐Mayouf, Sulaiman M., Al‐Sofyani, Fuad, Dāvidsone, Zane, Patrone, Elisa, Saad‐Magalhães, Claudia, Consolaro, A. and Ravelli, A. 2024. Defining criteria for disease activity states in systemic juvenile idiopathic arthritis based on the systemic Juvenile Arthritis Disease Activity Score. Arthritis & Rheumatology. https://doi.org/10.1002/art.42865

Journal article

Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study.
Montgomery-Csobán, Tünde, Kavanagh, Kimberley, Murray, Paul, Robertson, Chris, Barry, Sarah J E, Vivian Ukah, U, Payne, Beth A, Nicolaides, Kypros H, Syngelaki, Argyro, Ionescu, Olivia, Akolekar, Ranjit, Hutcheon, Jennifer A, Magee, Laura A, von Dadelszen, Peter and PIERS Consortium 2024. Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study. The Lancet. Digital health. 6 (4), pp. e238-e250. https://doi.org/10.1016/S2589-7500(23)00267-4

Journal article

Vasa previa in singleton pregnancies: Diagnosis and clinical management based on an international expert consensus
Oyelese, Yinka, Javinani, Ali, Gudanowski, Brittany, Krispin, Eyal, Rebarber, Andrei, Akolekar, R., Catanzarite, Val, D'Souza, Rohan, Bronsteen, Richard, Odibo, Anthony, Scheier, Matthias A, Hasegawa, Junichi, Jauniaux, Eric, Lees, Christoph, Srinivasan, Deepa, Daly-Jones, Elizabeth, Duncombe, Gregory, Melcer, Yaacov, Maymon, Ron, Silver, Robert, Prefumo, Federico, Tachibana, Daisuke, Henrich, Wolfgang, Cincotta, Robert, Shainker, Scott A, Ranzini, Angela C, Roman, Ashley S, Chmait, Ramen, Hernandez-Andrade, Edgar A, Rolnik, Daniel L, Sepulveda, Waldo and Shamshirsaz, Alireza A 2024. Vasa previa in singleton pregnancies: Diagnosis and clinical management based on an international expert consensus. American Journal of Obstetrics and Gynecology. 231 (6), pp. 638.e1-638.e24. https://doi.org/10.1016/j.ajog.2024.03.013

Journal article

Writing a research abstract for a conference: 12 tips to excel in your work
Sá-Couto, Carla, Buttery, Andy, Alinier, Guillaume and Weldon, Sharon 2024. Writing a research abstract for a conference: 12 tips to excel in your work. International Journal of Healthcare Simulation. pp. 1-3. https://doi.org/10.54531/hcnh5817

Journal article

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring.
Ling Li MB, Bin Wu MM, Jiaoxuan Dong MM, Songbin He MM, Jie Xu MM, Gary Tse PhD, Fangyu Dai MM and Haipeng Liu PhD 2024. Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring. Journal of Clinical Hypertension. 26 (2), pp. 122-133.

Journal article

The BVI ISOPURE ® 123 intraocular lens: a new hydrophobic preloaded extended monofocal IOL with intermediate vision correction
Ansari, Ejaz 2024. The BVI ISOPURE ® 123 intraocular lens: a new hydrophobic preloaded extended monofocal IOL with intermediate vision correction. Frontiers in Ophthalmology. 3, p. 1330335. https://doi.org/10.3389/fopht.2023.1330335

Journal article

Consensus on the definitions and descriptions of the domains of the OMERACT Core Outcome Set for shared decision making interventions in rheumatology trials
Décary, Simon, de Wit, Maarten, Naye, Florian, Barton, Jennifer L., Fraenkel, Liana, Li, Linda C., Brooks, Peter, Stacey, Dawn, Maxwell, Lara J., Campbell, Willemina, Hofstetter, Cathie, Voshaar, Marieke, Meara, Alexa, Christensen, Robin, Boonen, Annelies, Suarez-Almazor, Maria E., Meade, Tanya, March, Lyn, Jull, Janet Elizabeth, Alten, Rieke, Morgan, Esi M., Hazlewood, Glen, Barber, Claire, Guillemin, Francis, El-Miedany, Yasser, Mittoo, Shikha, Robertson, Tiffany Westrich, Bartlett, Susan J., Singh, Jasvinder A., Mannion, Melissa, Nasef, Samah Ismail, Boel, Anne, Adebajo, Adewale, Arnaud, Laurent, Gill, Tiffany K., Moholt, Ellen, Burt, Jennifer, Jayatilleke, Arundathi, Hmamouchi, Ihsane, Berthelsen, Dorthe B, Blanco, Francisco J., Mather, Kate, Maharaj, Ajesh, Sharma, Saurab, Caso, Francesco, Beaton, Dorcas, Shea, Beverly, Fong, Christopher, Fernandez, Anthony P., Mackie, Sarah, Nikiphorou, Elena, Jones, Allyson, Greer-Smith, Regina, Sloan, Victor S., Akpabio, Akpabio, Strand, Vibeke, Lee, Rebecca R., Umaefulam, Valerie, Monti, Sara, Abaza, Nouran, Schultz, Grayson, Stones, Simon, Gossec, Laure, Nielsen, Sabrina Mai, Cavallo, Sabrina, Srinivasalu, Hemalatha, Constien, Deb, Evans, Vicki, Tugwell, Peter and Toupin-April, K. 2024. Consensus on the definitions and descriptions of the domains of the OMERACT Core Outcome Set for shared decision making interventions in rheumatology trials. Seminars in Arthritis and Rheumatism. 65, p. 152381. https://doi.org/10.1016/j.semarthrit.2024.152381

Journal article

Interim analysis of serum placental growth factor values for use in pre-eclampsia screening
Golob, E., Jones, S., Ganapathy, R. and Akolekar, R. 2023. Interim analysis of serum placental growth factor values for use in pre-eclampsia screening. Ultrasound in Obstetrics & Gynecology. https://doi.org/10.1002/uog.27570

Journal article

Gestational diabetes mellitus: Association with maternal and neonatal complications
Karkia, R., Giacchino, T., Shah, Saadia, Gough, Andrew, Ramadan, G. and Akolekar, R. 2023. Gestational diabetes mellitus: Association with maternal and neonatal complications. Medicina (Kaunas, Lithuania). 59 (12), p. 2096. https://doi.org/10.3390/medicina59122096

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Core outcome measurement set for shared decision making in rheumatic and musculoskeletal conditions: A scoping review to identify candidate instruments
Naye, Florian, Toupin-April, Karine, de Wit, Maarten, LeBlanc, Annie, Dubois, Olivia, Boonen, Annelies, Barton, Jennifer L., Fraenkel, Liana, Li, Linda C., Stacey, Dawn, March, Lyn, Barber, Claire E.H., Hazlewood, Glen Stewart, Guillemin, Francis, Bartlett, Susan J., Berthelsen, Dorthe B., Mather, Kate, Arnaud, Laurent, Akpabio, Akpabio, Adebajo, Adewale, Schultz, Grayson, Sloan, Victor S., Gill, Tiffany K., Sharma, Saurab, Scholte-Voshaar, Marieke, Caso, Francesco, Nikiphorou, Elena, Nasef, Samah Ismail, Campbell, Willemina, Meara, Alexa, Christensen, Robin, Suarez-Almazor, Maria E., Jull, Janet Elizabeth, Alten, Rieke, Morgan, Esi M., El-Miedany, Yasser, Singh, Jasvinder A., Burt, Jennifer, Jayatilleke, Arundathi, Hmamouchi, Ihsane, Blanco, Francisco J., Fernandez, Anthony P., Mackie, Sarah, Jones, Allyson, Strand, Vibeke, Monti, Sara, Stones, Simon R., Lee, Rebecca R., Nielsen, Sabrina Mai, Evans, Vicki, Srinivasalu, Hemalatha, Gérard, Thomas, Demers, Juliette LeBlanc, Bouchard, Roxanne, Stefan, Théo, Dugas, Michèle, Bergeron, Frédéric, Beaton, Dorcas, Maxwell, Lara J., Tugwell, Peter and Décary, Simon 2023. Core outcome measurement set for shared decision making in rheumatic and musculoskeletal conditions: A scoping review to identify candidate instruments. Seminars in Arthritis and Rheumatism. 65, p. 152344. https://doi.org/10.1016/j.semarthrit.2023.152344

Journal article

Pregnancy-An ideal period to identify women at risk for chronic hypertension
Charakida, M., Wright, A., Magee, L., Syngelaki, A., von Dadelszen, P., Akolekar, R., Nicolaides, K. and Wright, David 2023. Pregnancy-An ideal period to identify women at risk for chronic hypertension. Hypertension. 81 (2), pp. 311-318. https://doi.org/10.1161/HYPERTENSIONAHA.123.21573

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Placental growth factor testing at 19–23 weeks of gestation as a guide to subsequent care in pregnancy: A prospective observational study
Magee, L., Syngelaki, Argyro, Akolekar, R., von Dadelszen, P. and Nicolaides, K. 2023. Placental growth factor testing at 19–23 weeks of gestation as a guide to subsequent care in pregnancy: A prospective observational study. BJOG: An International Journal of Obstetrics & Gynaecology. 131 (6), pp. 803-810. https://doi.org/10.1111/1471-0528.17684

Journal article

Five-year outcomes of ab interno Xen 45 gel stent implantation
Ansari, E. 2023. Five-year outcomes of ab interno Xen 45 gel stent implantation. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. https://doi.org/10.1007/s00417-023-06294-9

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Beyond the symptoms: Personalizing giant cell arteritis care through multidimensional patient reported outcome measure
El Miedany, Y., El Gaafary, M, Toth, M, Palmer, D., Ali, Ayman, Bahlas, S., Mahran, S., Hassan, W., Abu-Zaid, M H, Saber, S. and Elwakil, W. 2023. Beyond the symptoms: Personalizing giant cell arteritis care through multidimensional patient reported outcome measure. Seminars in Arthritis and Rheumatism. 63, p. 152285. https://doi.org/10.1016/j.semarthrit.2023.152285

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Management of preterm labor: Clinical practice guideline and recommendation by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation
Dagklis, Themistoklis, Akolekar, Ranjit, Villalain, Cecilia, Tsakiridis, Ioannis, Kesrouani, Assaad, Tekay, Aydin, Plasencia, Walter, Wellmann, Sven, Kusuda, Satoshi, Jekova, Nelly, Prefumo, Federico, Volpe, Nicola, Chaveeva, Petya, Allegaert, Karel, Khalil, Asma and Sen, Cihat 2023. Management of preterm labor: Clinical practice guideline and recommendation by the WAPM-World Association of Perinatal Medicine and the PMF-Perinatal Medicine Foundation. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 291, pp. 196-205. https://doi.org/10.1016/j.ejogrb.2023.10.013

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OP08.09: Causes of death and perinatal mortality rate in patients with prenatally diagnosed vasa previa: a systematic review and meta‐analysis
Javinani, A., Conyers, S., Jamali, M., Zargarzadeh, N., Akolekar, R., Hasegawa, J., Meltcer, Y., Maymon, R., Bronsteen, R., Roman, A., Shamshirsaz, A. and Oyelese, Y. 2023. OP08.09: Causes of death and perinatal mortality rate in patients with prenatally diagnosed vasa previa: a systematic review and meta‐analysis. Ultrasound in Obstetrics & Gynecology. 62 (S1), pp. 68-69. https://doi.org/10.1002/uog.26518

Journal article

Pilot study: design, delivery and evaluation of a co-produced multi-agency mental health simulation-based education programme
Clarke, Isobel, Philpott, Lauren and Buttery, Andy 2023. Pilot study: design, delivery and evaluation of a co-produced multi-agency mental health simulation-based education programme. International Journal of Healthcare Simulation. pp. 1-12. https://doi.org/10.54531/qzcr2106

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Incidence of vasa praevia: a systematic review and meta-analysis
Zhang, Weiyu, Giacchino, Tara, Chanyarungrijn, P. A., Ionescu, Olivia and Akolekar, R. 2023. Incidence of vasa praevia: a systematic review and meta-analysis. BMJ Open. 13 (9), p. e075245. https://doi.org/10.1136/bmjopen-2023-075245

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Prediction of hypertensive disorders after screening at 36 weeks' gestation: comparison of angiogenic markers with competing‐risks model
Schiattarella, A., Magee, L., Wright, A., Syngelaki, A., Akolekar, R., von Dadelszen, P. and Nicolaides, K. H. 2023. Prediction of hypertensive disorders after screening at 36 weeks' gestation: comparison of angiogenic markers with competing‐risks model. Ultrasound in Obstetrics & Gynecology. 62 (3), pp. 345-352. https://doi.org/10.1002/uog.26291

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Incidence of pre‐eclampsia: effect of deprivation
Arechvo, A., Syngelaki, A., Wright, A., Magee, L., von Dadelszen, P., Akolekar, R., Wright, D. and Nicolaides, K. H. 2023. Incidence of pre‐eclampsia: effect of deprivation. Ultrasound in Obstetrics & Gynecology. 61 (1), pp. 26-32. https://doi.org/10.1002/uog.26084

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Maternal and neonatal complications following Kielland's rotational forceps delivery: A systematic review and meta‐analysis
Giacchino, Tara, Karkia, Rebecca, Ahmed, Hasib and Akolekar, R. 2023. Maternal and neonatal complications following Kielland's rotational forceps delivery: A systematic review and meta‐analysis. BJOG: An International Journal of Obstetrics & Gynaecology. 130 (8), pp. 856-864. https://doi.org/10.1111/1471-0528.17402

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Preeclampsia prevention by timed birth at term
Magee, L., Wright, David, Syngelaki, A., von Dadelszen, P., Akolekar, R., Wright, A. and Nicolaides, K. 2023. Preeclampsia prevention by timed birth at term. Hypertension. 80 (5), pp. 969-78. https://doi.org/10.1161/HYPERTENSIONAHA.122.20565

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Relation of antepartum stillbirth to birthweight and gestational age: Prospective cohort study.
Papastefanou, I., Ashoor, Ghalia, Syngelaki, Argyro, Akolekar, R. and Nicolaides, Kypros H 2023. Relation of antepartum stillbirth to birthweight and gestational age: Prospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 131 (2), pp. 200-206. https://doi.org/10.1111/1471-0528.17652

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Maternal and neonatal complications in pregnancies with and without pre-gestational diabetes mellitus
Karkia, Rebecca, Giacchino, Tara, Watson, Helen, Gough, Andrew, Ramadan, Ghada and Akolekar, R. 2023. Maternal and neonatal complications in pregnancies with and without pre-gestational diabetes mellitus. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2023-0183

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A-294 duplicate testing of samples suspected of SARS-CoV-2 infection could prevent misdiagnosis of Covid-19
Sánchez-Sánchez, J, Thapa, G, Mylona, A and Vuono, R 2023. A-294 duplicate testing of samples suspected of SARS-CoV-2 infection could prevent misdiagnosis of Covid-19. Clinical Chemistry. 69 (Supplement_1). https://doi.org/10.1093/clinchem/hvad097.259

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Efficiency of the cerebroplacental ratio in Identifying high-risk late-term pregnancies
Martin-Alonso, R., Rolle, V., Akolekar, R., de Paco Matallana, Catalina, Fernández-Buhigas, I., Sánchez-Camps, Maria Isabel, Giacchino, T., Rodríguez-Fernández, Miguel, Blanco-Carnero, Jose Eliseo, Santacruz, Belén and Gil, María M. 2023. Efficiency of the cerebroplacental ratio in Identifying high-risk late-term pregnancies. Medicina (Kaunas, Lithuania). 59 (9), p. 1670. https://doi.org/10.3390/medicina59091670

Journal article

De novo stone formation in ureteric stump post-nephrectomy
Ahmed Mohamed, Omer Abdalla, Banan Omer, Madaan, S. and Seshadri Sriprasad 2023. De novo stone formation in ureteric stump post-nephrectomy. Journal of Endoluminal Endourology. https://doi.org/10.22374/jeleu.v6i1.158

Journal article

Collision metastasis from prostate adenocarcinoma and pancreatic ductal adenocarcinoma to a lung nodule
Mohamed, A., Yao, M., Saw, S., Clark, A. and Madaan, S. 2023. Collision metastasis from prostate adenocarcinoma and pancreatic ductal adenocarcinoma to a lung nodule. JRSM Open. 14 (3). https://doi.org/10.1177/20542704231153562

Journal article

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