The evolution of targeted intra operative radiotherapy in early breast cancer

Journal article

Das, Aparimita, Abdulkarim, Khadeer, Banerjee, Soirindhri, Kurmude, Riya, Tan, Joecelyn Kirani, Prusty, Lydia, Mahajan, Ishika, Ghose, Aruni, Tiwari, Aaditya, Kassamali, Abbas, Hasanova, Maryam, Chapagain, Pratima, Linares, Christian A, Vaidya, Jayant S and Boussios, Stergios 2025. The evolution of targeted intra operative radiotherapy in early breast cancer. Journal of Cancer Research and Clinical Oncology. 151 (9), p. 249. https://doi.org/10.1007/s00432-025-06294-8
AuthorsDas, Aparimita, Abdulkarim, Khadeer, Banerjee, Soirindhri, Kurmude, Riya, Tan, Joecelyn Kirani, Prusty, Lydia, Mahajan, Ishika, Ghose, Aruni, Tiwari, Aaditya, Kassamali, Abbas, Hasanova, Maryam, Chapagain, Pratima, Linares, Christian A, Vaidya, Jayant S and Boussios, Stergios
AbstractTargeted intraoperative radiotherapy (IORT) delivers a single dose of radiation to a fresh tumour bed immediately after lumpectomy, commonly used to treat early breast cancer (EBC). It is delivered during the same sitting, with improved patient compliance and better sparing of adjacent healthy tissue, compared to conventional adjuvant radiotherapy to the whole breast. The recently published 12-year results (median follow up of 8.6 years) of the TARGIT-A trial offers reliable conclusions, of comparable oncological outcomes with a reduced toxicity profile supporting IORT as a replacement for whole breast external beam radiotherapy (EBRT) for suitable patients with EBC. Reduced need of multiple hospital visits is an added logistic advantage which makes IORT a cost-effective, less painful and cosmetically favourable alternative to standard EBRT, now included in several international guidelines with growing popularity among clinicians worldwide.
KeywordsBreast cancer; Radiotherapy; Intraoperative; Targit; Breast Conserving Surgery; Accelerated Partial Breast Irradiation; External Beam; Whole Breast Irradiation; Humans; Breast Neoplasms; Radiotherapy, Adjuvant; Intraoperative Care; Mastectomy, Segmental; Female
Year2025
JournalJournal of Cancer Research and Clinical Oncology
Journal citation151 (9), p. 249
PublisherSpringer
ISSN1432-1335
0171-5216
Digital Object Identifier (DOI)https://doi.org/10.1007/s00432-025-06294-8
Official URLhttps://link.springer.com/article/10.1007/s00432-025-06294-8
Publication dates
Online10 Sep 2025
Print01 Sep 2025
Publication process dates
Accepted14 Aug 2025
Deposited11 Sep 2025
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Open
Output statusPublished
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