Associations between glucocorticoid use and major adverse cardiovascular events in patients with prostate cancer receiving antiandrogen: a retrospective cohort study.
Journal article
Chan, J., Lee, Y. H. A., Leung, C., Leung, David Ka Wai, Dee, E., Ng, Kenrick, Tse, G. and Ng, C. 2024. Associations between glucocorticoid use and major adverse cardiovascular events in patients with prostate cancer receiving antiandrogen: a retrospective cohort study. Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/s41391-024-00889-x
Authors | Chan, J., Lee, Y. H. A., Leung, C., Leung, David Ka Wai, Dee, E., Ng, Kenrick, Tse, G. and Ng, C. |
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Abstract | Prednisolone/prednisone coadministration with abiraterone may explain abiraterone-related increase in cardiovascular risk. We explored this postulation and glucocorticoid's association with cardiovascular risk. Patients with prostate cancer on androgen deprivation therapy and enzalutamide, or abiraterone with 5 mg (ABI + P5) or 10 mg (ABI + P10) daily total prednisolone/prednisone were followed up for major adverse cardiovascular events (MACE). We analyzed 933 patients. ABI + P10, but not enzalutamide, had higher risk of MACE than ABI + P5. Cumulative glucocorticoid dose before enzalutamide/abiraterone initiation was associated with MACE. Prednisolone/prednisone coadministration with abiraterone likely contributed to abiraterone-related increased cardiovascular risk. Prevalent cumulative glucocorticoid dose was associated with cardiovascular risk. [Abstract copyright: © 2024. The Author(s).] |
Keywords | Cancer therapy; Outcomes research; Prostate cancer |
Year | 2024 |
Journal | Prostate Cancer and Prostatic Diseases |
Publisher | Springer Nature |
ISSN | 1476-5608 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41391-024-00889-x |
Official URL | https://www.nature.com/articles/s41391-024-00889-x |
Funder | NCI NIH HHS |
Publication dates | |
Online | 10 Sep 2024 |
Publication process dates | |
Accepted | 23 Aug 2024 |
Deposited | 25 Sep 2024 |
Publisher's version | License File Access Level Open |
Output status | Published |
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https://repository.canterbury.ac.uk/item/99270/associations-between-glucocorticoid-use-and-major-adverse-cardiovascular-events-in-patients-with-prostate-cancer-receiving-antiandrogen-a-retrospective-cohort-study
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