Prevalence, clinical characteristics, and long-term outcomes of new diabetes diagnosis in elderly patients undergoing percutaneous coronary intervention.
Journal article
Xue, Zheng-Kai, Dai, Xin-Ya, Ren, Jia-Yi, Liu, Tong, Zhang, Yu-Kun, Hu, Su-Tao, Wang, Peng, Wu, Xue, Zhang, Jing-Kun, Tse, Gary, Park, Soohyung, Choi, Cheol-Ung, Choi, Byoung-Geol, Rha, Seung-Woon and Chen, Kang-Yin 2024. Prevalence, clinical characteristics, and long-term outcomes of new diabetes diagnosis in elderly patients undergoing percutaneous coronary intervention. Scientific Reports. 14 (1), p. 14814. https://doi.org/10.1038/s41598-024-65426-1
| Authors | Xue, Zheng-Kai, Dai, Xin-Ya, Ren, Jia-Yi, Liu, Tong, Zhang, Yu-Kun, Hu, Su-Tao, Wang, Peng, Wu, Xue, Zhang, Jing-Kun, Tse, Gary, Park, Soohyung, Choi, Cheol-Ung, Choi, Byoung-Geol, Rha, Seung-Woon and Chen, Kang-Yin |
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| Abstract | Previous studies have reported associations between newly diagnosed diabetes and poor outcomes after percutaneous coronary intervention (PCI), but there is limited data focusing on elderly patients (age ≥ 65). This study aimed to analyze the prevalence and clinical implications of newly diagnosed diabetes in elderly patients who underwent PCI. From 2004 to 2021, a total of 2456 elderly patients who underwent invasive PCI at Korea University Guro Hospital were prospectively enrolled and followed up for a median of five years. The primary endpoint was five-year major adverse cardiovascular events (MACE). Cox regression was used to evaluate whether newly diagnosed diabetes impacted on long-term clinical outcomes. Newly diagnosed diabetes was presented in approximately 8.1% to 10.9% of elderly patients who underwent PCI. Those who had a new diagnosis of diabetes had a higher risk of MACE than previously known diabetes (25.28% vs. 19.15%, p = 0.039). After adjusting for significant factors, newly diagnosed diabetes remained an independent predictor of MACE (HR [hazard ratio] 1.64, 95% confidence interval [CI] 1.24-2.17, p < 0.001), cardiac death (HR 2.15, 95% CI 1.29-3.59, p = 0.003) and repeat revascularization (HR 1.52, 95% CI 1.09-2.11, p = 0.013), but not for non-fatal myocardial infarction (HR 1.66, 95% CI 0.94-2.12, p = 0.081). Newly diagnosed diabetes was associated with an increased risk of 5-year MACE compared with non-diabetes and previously diagnosed diabetes in elderly patients underwent PCI. More attention should be given to those elderly newly diagnosed diabetes population. [Abstract copyright: © 2024. The Author(s).] |
| Keywords | Percutaneous coronary intervention - adverse effects; Newly diagnosed diabetes; Proportional hazards models; Risk factors; Prevalence; Aged; Republic of Korea - epidemiology; Prospective Studies; Coronary artery disease; Diabetes mellitus - epidemiology |
| Year | 2024 |
| Journal | Scientific Reports |
| Journal citation | 14 (1), p. 14814 |
| Publisher | Springer Nature |
| ISSN | 2045-2322 |
| Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-024-65426-1 |
| Official URL | https://www.nature.com/articles/s41598-024-65426-1 |
| Funder | Key Project of Tianjin Natural Science Foundation |
| Publication dates | |
| Online | 27 Jun 2024 |
| Publication process dates | |
| Accepted | 20 Jun 2024 |
| Deposited | 11 Jul 2024 |
| Publisher's version | License File Access Level Open |
| Output status | Published |
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https://repository.canterbury.ac.uk/item/985wy/prevalence-clinical-characteristics-and-long-term-outcomes-of-new-diabetes-diagnosis-in-elderly-patients-undergoing-percutaneous-coronary-intervention
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