Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment

Journal article

Huang, Helen Ye Rim, Wireko, A., Miteu, Goshen David, Khan, Adan, Roy, Sakshi, Ferreira, Tomas, Garg, Tulika, Aji, Narjiss, Haroon, Faaraea, Zakariya, Farida, Alshareefy, Yasir, Pujari, Anushka Gurunath, Madani, Djabir and Papadakis, Marios 2024. Advancements and progress in juvenile idiopathic arthritis: A Review of pathophysiology and treatment. Medicine. 103 (13), p. e37567. https://doi.org/10.1097/md.0000000000037567
AuthorsHuang, Helen Ye Rim, Wireko, A., Miteu, Goshen David, Khan, Adan, Roy, Sakshi, Ferreira, Tomas, Garg, Tulika, Aji, Narjiss, Haroon, Faaraea, Zakariya, Farida, Alshareefy, Yasir, Pujari, Anushka Gurunath, Madani, Djabir and Papadakis, Marios
AbstractJuvenile idiopathic arthritis (JIA) is a chronic clinical condition characterized by arthritic features in children under the age of 16, with at least 6 weeks of active symptoms. The etiology of JIA remains unknown, and it is associated with prolonged synovial inflammation and structural joint damage influenced by environmental and genetic factors. This review aims to enhance the understanding of JIA by comprehensively analyzing relevant literature. The focus lies on current diagnostic and therapeutic approaches and investigations into the pathoaetiologies using diverse research modalities, including in vivo animal models and large-scale genome-wide studies. We aim to elucidate the multifactorial nature of JIA with a strong focus towards genetic predilection, while proposing potential strategies to improve therapeutic outcomes and enhance diagnostic risk stratification in light of recent advancements. This review underscores the need for further research due to the idiopathic nature of JIA, its heterogeneous phenotype, and the challenges associated with biomarkers and diagnostic criteria. Ultimately, this contribution seeks to advance the knowledge and promote effective management strategies in JIA.
KeywordsGenetics ; Immunology; Juvenile idiopathic arthritis; Rheumatology; Risk stratification; Treatment
Year2024
JournalMedicine
Journal citation103 (13), p. e37567
PublisherOvid Technologies (Wolters Kluwer Health)
ISSN0025-7974
1536-5964
Digital Object Identifier (DOI)https://doi.org/10.1097/md.0000000000037567
Official URLhttps://journals.lww.com/md-journal/fulltext/2024/03290/advancements_and_progress_in_juvenile_idiopathic.70.aspx
Publication dates
Online29 Mar 2024
Print29 Mar 2024
Publication process dates
Accepted20 Feb 2024
Deposited08 Apr 2024
Publisher's version
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File Access Level
Open
Output statusPublished
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