Immunotherapy combined with standard therapies in head and neck squamous cell carcinoma - a meta-analysis

Journal article

Eden, Daisy, Ghose, Aruni, Moschetta, Michele, Pérez-Fidalgo, José Alejandro, Rassy, Elie and Boussios, Stergios 2024. Immunotherapy combined with standard therapies in head and neck squamous cell carcinoma - a meta-analysis. Anticancer Research. 44 (3), pp. 861-878. https://doi.org/10.21873/anticanres.16880
AuthorsEden, Daisy, Ghose, Aruni, Moschetta, Michele, Pérez-Fidalgo, José Alejandro, Rassy, Elie and Boussios, Stergios
AbstractHead and neck squamous cell carcinoma (HNSCC) is a deadly disease with a poor prognosis due to late diagnosis and limited treatment options. Immunotherapy (IT) is emerging as a promising approach, especially after the failure of standard of care therapies (STs). The objective of this systematic review and meta-analysis was to evaluate whether the addition of IT to STs improves outcomes for patients with HNSCC, including overall survival (OS), progression-free survival (PFS), and quality of life (QoL). This review employed the Population Intervention Comparison and Outcome (PICO) framework to identify relevant search terms in electronic databases, and also included supplementary hand searches. Six primary research articles were selected using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) flow chart, and were critically appraised. Data extraction from these studies was conducted, and a meta-analysis was performed to aid in the generation of forest plots. The addition of IT to standard anticancer therapies was found to enhance patient outcomes, such as OS, PFS, and QoL. The toxicity profile of IT was acceptable, with minimal treatment-related deaths. The most frequently observed adverse events (AE) were related to the skin, followed by hematological toxicities. Based on our analysis, the addition of IT to STs is a suitable treatment option and is supported by current research. However, further studies are needed to investigate factors that influence treatment effectiveness and to develop optimal therapies. To achieve this, we recommend a comprehensive treatment approach that involves the multidisciplinary team (MDT) and patient assessment tools. [Abstract copyright: Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.]
KeywordsHead and neck squamous cell carcinoma; Head and neck cancer; Immunotherapy
Year2024
JournalAnticancer Research
Journal citation44 (3), pp. 861-878
PublisherInternational Institute of Anticancer Research
ISSN1791-7530
Digital Object Identifier (DOI)https://doi.org/10.21873/anticanres.16880
Official URLhttps://ar.iiarjournals.org/content/44/3/861.long
Publication dates
OnlineMar 2024
Publication process dates
Accepted07 Feb 2024
Deposited14 Mar 2024
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