Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4

Journal article

Ghose, A., McCann, Lucy, Makker, S., Mukherjee, Uma, Gullapalli, Sri Vidya Niharika, Erekkath, Jayaraj, Shih, Stephanie, Mahajan, Ishika, Sanchez, Elisabet, Uccello, Mario, Moschetta, Michele, Adeleke, S. and Boussios, Stergios 2024. Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4. Therapeutic Advances in Medical Oncology. 16, p. 1758835924123225. https://doi.org/10.1177/17588359241233225
AuthorsGhose, A., McCann, Lucy, Makker, S., Mukherjee, Uma, Gullapalli, Sri Vidya Niharika, Erekkath, Jayaraj, Shih, Stephanie, Mahajan, Ishika, Sanchez, Elisabet, Uccello, Mario, Moschetta, Michele, Adeleke, S. and Boussios, Stergios
AbstractOvarian cancer (OC) is the most lethal gynaecologic malignancy, attributed to its insidious growth, non-specific symptoms and late presentation. Unfortunately, current screening modalities are inadequate at detecting OC and many lack the appropriate specificity and sensitivity that is desired from a screening test. Nearly 70% of cases are diagnosed at stage III or IV with poor 5-year overall survival. Therefore, the development of a sensitive and specific biomarker for early diagnosis and screening for OC is of utmost importance. Currently, diagnosis is guided by CA125, the patient’s menopausal status and imaging features on ultrasound scan. However, emerging evidence suggests that a combination of CA125 and HE4 (another serum biomarker) and patient characteristics in a multivariate index assay may provide a higher specificity and sensitivity than either CA125 and HE4 alone in the early detection of OC. Other attempts at combining various serum biomarkers into one multivariate index assay such as OVA1, ROMA and Overa have all shown promise. However, significant barriers exist before these biomarkers can be implemented in clinical practice. This article aims to provide an up-to-date review of potential biomarkers for screening and early diagnosis of OC which may have the potential to transform its diagnostic landscape.
KeywordsCirculating tumour biomarkers; Diagnostic biomarkers; Molecular testing; Ovarian cancer; Tumour biomarkers
Year2024
JournalTherapeutic Advances in Medical Oncology
Journal citation16, p. 1758835924123225
PublisherSAGE
ISSN1758-8359
1758-8340
Digital Object Identifier (DOI)https://doi.org/10.1177/17588359241233225
Official URLhttps://journals.sagepub.com/doi/10.1177/17588359241233225
Publication dates
Online29 Feb 2024
Publication process dates
Deposited11 Mar 2024
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