Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation

Journal article

Tumbapo, Sobha, Strudwick, Adam, Stastna, Jana J., Harvey, Simon C. and Bloemink, Marieke J. 2024. Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation. Mechanisms of Ageing and Development. 217, p. 111900. https://doi.org/10.1016/j.mad.2023.111900
AuthorsTumbapo, Sobha, Strudwick, Adam, Stastna, Jana J., Harvey, Simon C. and Bloemink, Marieke J.
AbstractSarcopenia, a gradual decrease in skeletal muscle mass and strength, is a major component of frailty in the elderly, with age, (lack of) exercise and diet found to be the major risk factors. The nematode Caenorhabditis elegans is an important model of sarcopenia. Although many studies describe loss of muscle function in ageing C. elegans, surprisingly few report on the loss of muscle mass. Here, in order to quantify loss of muscle mass under various dietary restriction (DR) conditions, we used an internal GFP standard to determine levels of the major body wall muscle myosin (UNC-54) in transgenic unc-54::gfp worms over their lifespan. Myosin density linearly increased during the first week of adulthood and there was no significant effect of DR. In contrast, an exponential decrease in myosin density was seen during the second week of adulthood, with reduced rates of myosin loss for mild and medium DR compared to control. UNC-54 turnover rates, previously determined using pulse-labelling methods, correspond well with the t1/2 value found here for UNC-54-GFP using fluorescence (control t1/2 = 12.0 days), independently validating our approach. These data indicate that sarcopenia is delayed in worms under mild and medium DR due to a reduced rate of myosin UNC-54 degradation, thereby maintaining protein homeostasis.
KeywordsAging; Sarcopenia; C. elegans; Healthspan; Myosin UNC-54
Year2024
JournalMechanisms of Ageing and Development
Journal citation217, p. 111900
PublisherElsevier
ISSN0047-6374
Digital Object Identifier (DOI)https://doi.org/10.1016/j.mad.2023.111900
Official URLhttps://www.sciencedirect.com/science/article/pii/S0047637423001264
Publication dates
Online30 Dec 2023
Print12 Jan 2024
Publication process dates
Accepted26 Dec 2023
Deposited03 Jan 2024
Output statusPublished
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https://repository.canterbury.ac.uk/item/96v0q/moderate-dietary-restriction-delays-the-onset-of-age-associated-sarcopenia-in-caenorhabditis-elegans-due-to-reduced-myosin-unc-54-degradation

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