Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia. Alzheimer's & Dementia
Journal article
Hardy, C.J.D., Taylor-Rubin, C., Harding, H., Suárez-Gonzalez, A., Jiang, J., Thompson, L, Kingma, K., Chokesuwattanaskul, A., Walker, F., Barker, S., Brotherhood, E.V., Waddington,C., Wood, O., Zimmerman, N., Kupeli,N., Yong, K.X.X., Camic, P.M., Scott, J., Marshall, C.R., Oxtoby, N.P., Rohrer, J.D., Volkmer, A., Crutch, S.J. and Warren, J.D. 2023. Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia. Alzheimer's & Dementia. Alzheimer's & Dementia. https://doi.org/10.1002/alz.13415
| Authors | Hardy, C.J.D., Taylor-Rubin, C., Harding, H., Suárez-Gonzalez, A., Jiang, J., Thompson, L, Kingma, K., Chokesuwattanaskul, A., Walker, F., Barker, S., Brotherhood, E.V., Waddington,C., Wood, O., Zimmerman, N., Kupeli,N., Yong, K.X.X., Camic, P.M., Scott, J., Marshall, C.R., Oxtoby, N.P., Rohrer, J.D., Volkmer, A., Crutch, S.J. and Warren, J.D. |
|---|---|
| Abstract | INTRODUCTION: Here we set out to create a symptom-led staging system for the METHODS: An international PPA caregiver cohort was surveyed on symptom development under six provisional clinical stages and feedback was analyzed using a mixed-methods sequential explanatory design. RESULTS: Both PPA syndromes were characterized by initial communication dysfunction and non-verbal behavioral changes, with increasing syndromic convergence and functional dependency at later stages. Milestone symptoms were distilled to create a prototypical progression and severity scale of functional impairment: the PPA Progression Planning Aid (“PPA-Squared”). DISCUSSION: This work introduces a symptom-led staging scheme and functional |
| Keywords | Frontotemporal dementia; Primary progressive aphasia; Primary progressive non-fluent/ agrammatic aphasia, ; Progression planning aid; Semantic dementia; Staging |
| Year | 2023 |
| Journal | Alzheimer's & Dementia |
| Publisher | Wiley |
| ISSN | 1552-5260 |
| 1552-5279 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1002/alz.13415 |
| Official URL | https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.13415 |
| Funder | National Institute for Health and Care Research (NIHR) |
| Publication dates | |
| 07 Aug 2023 | |
| Publication process dates | |
| Accepted | 10 Jul 2023 |
| Deposited | 09 Nov 2023 |
| Publisher's version | License File Access Level Open |
| Output status | Published |
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