Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options.
Journal article
Panneerselvam, S., Wilson, Cornelia, Kumar, Prem, Abirami, Dinu, Pamarthi, Jayakrishna, Reddy, Mettu Srinivas and Varghese, Joy 2023. Overview of hepatocellular carcinoma: from molecular aspects to future therapeutic options. Cell Adhesion and Migration. 17 (1), pp. 1-21. https://doi.org/10.1080/19336918.2023.2258539
Authors | Panneerselvam, S., Wilson, Cornelia, Kumar, Prem, Abirami, Dinu, Pamarthi, Jayakrishna, Reddy, Mettu Srinivas and Varghese, Joy |
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Abstract | Hepatocellular carcinoma (HCC) is the seventh most highly prevalent malignant tumor globally and the second most common cause of mortality. HCC develops with complex pathways that occur through multistage biological processes. Non-alcoholic fatty liver disease, metabolic-associated fatty liver disease, alcoholic liver disease, autoimmune hepatitis, hepatitis B, and hepatitis C are the causative etiologies of HCC. HCC develops as a result of epigenetic changes, protein-coding gene mutations, and altered signaling pathways. Biomarkers and potential therapeutic targets for HCC open up new possibilities for treating the disease. Immune checkpoint inhibitors are included in the treatment options in combination with molecular targeted therapy. |
Keywords | Immunotherapy; Cell Signaling Pathways; Circulating Tumour Cell; Hcc Biomarkers; Multi-Omics Technology; Humans; Carcinoma, Hepatocellular; Liver Neoplasms; Mutation; Molecular Targeted Therapy |
Year | 2023 |
Journal | Cell Adhesion and Migration |
Journal citation | 17 (1), pp. 1-21 |
ISSN | 1933-6918 |
1933-6926 | |
Digital Object Identifier (DOI) | https://doi.org/10.1080/19336918.2023.2258539 |
Official URL | https://www.tandfonline.com/doi/full/10.1080/19336918.2023.2258539 |
Funder | reported that there is no funding associated with the work featured in this article |
Publication dates | |
Online | 19 Sep 2023 |
01 Dec 2023 | |
Publication process dates | |
Accepted | 08 Sep 2023 |
Deposited | 28 Sep 2023 |
Output status | Published |
Additional information | Publications router: Date 2023-09-19 of type 'publication_date' with format 'electronic' included in notification |
Publications router: License for this article: cc by included in notification | |
License | CC BY |
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