Associations between modifiable risk factors and frailty: a Mendelian randomisation study

Journal article

Zhang, Nan, Jia, Ziheng, Gu, Tianshu, Zheng, Yi, Zhang, Yunpeng, Song, Wenhua, Chen, Ziliang, Li, Guangping, Tse, Gary and Liu, T. 2023. Associations between modifiable risk factors and frailty: a Mendelian randomisation study. Journal of Epidemiology and Community Health. 77 (12), pp. 782-790. https://doi.org/10.1136/jech-2023-220882
AuthorsZhang, Nan, Jia, Ziheng, Gu, Tianshu, Zheng, Yi, Zhang, Yunpeng, Song, Wenhua, Chen, Ziliang, Li, Guangping, Tse, Gary and Liu, T.
Abstract

Background
Early identification of modifiable risk factors is essential for the prevention of frailty. This study aimed to explore the causal relationships between a spectrum of genetically predicted risk factors and frailty.

Methods
Univariable and multivariable Mendelian randomisation (MR) analyses were performed to explore the relationships between 22 potential risk factors and frailty, using summary genome-wide association statistics. Frailty was accessed by the frailty index.

Results
Genetic liability to coronary artery disease (CAD), type 2 diabetes mellitus (T2DM), ischaemic stroke, atrial fibrillation and regular smoking history, as well as genetically predicted 1-SD increase in body mass index, systolic blood pressure, diastolic blood pressure, low-density lipoprotein cholesterol, triglycerides, alcohol intake frequency and sleeplessness were significantly associated with increased risk of frailty (all p<0.001). In addition, there was a significant inverse association between genetically predicted college or university degree with risk of frailty (beta −0.474; 95% CI (−0.561 to –0.388); p<0.001), and a suggestive inverse association between high-density lipoprotein cholesterol level with risk of frailty (beta −0.032; 95% CI (−0.055 to –0.010); p=0.004). However, no significant causal associations were observed between coffee consumption, tea consumption, serum level of total testosterone, oestradiol, 25-hydroxyvitamin D, C reactive protein or moderate to vigorous physical activity level with frailty (all p>0.05). Results of the reverse directional MR suggested bidirectional causal associations between T2DM and CAD with frailty.

Conclusions
This study provided genetic evidence for the causal associations between several modifiable risk factors with lifetime frailty risk. A multidimensional approach targeting these factors may hold a promising prospect for prevention frailty.

KeywordsRisk factors; Frailty
Year2023
JournalJournal of Epidemiology and Community Health
Journal citation77 (12), pp. 782-790
PublisherBMJ Publishing Group
ISSN0143-005X
1470-2738
Digital Object Identifier (DOI)https://doi.org/10.1136/jech-2023-220882
Official URLhttps://jech.bmj.com/content/early/2023/08/21/jech-2023-220882
FunderTianjin Key Medical Discipline (Specialty) Construction Project
Tianjin Natural Science Foundation
National Natural Science Foundation of China
Publication dates
Online21 Aug 2023
Publication process dates
Accepted08 Aug 2023
Deposited20 Sep 2023
Output statusPublished
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Sodium‐glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors on new‐onset overall cancer in Type 2 diabetes mellitus: A population‐based study
Chung, Cheuk To, Lakhani, Ishan, Chou, Oscar Hou In, Lee, Teddy Tai Loy, Dee, Christopher, Ng, Kendrick, Wong, Wing Tak, Liu, T., Lee, Sharen, Zhang, Qingpeng, Cheung, Bernard Man Yung, Tse, Gary and Zhou, Jiandong 2023. Sodium‐glucose cotransporter 2 inhibitors versus dipeptidyl peptidase 4 inhibitors on new‐onset overall cancer in Type 2 diabetes mellitus: A population‐based study. Cancer Medicine. https://doi.org/10.1002/cam4.5927
The role of electrophysiological study in the risk stratification of Brugada Syndrome
Bazoukis, George, Chung, Cheuk To, Vassiliou, Vassilios S, Sfairopoulos, Dimitrios, Lee, Sharen, Papadatos, Stamatis S, Korantzopoulos, Panagiotis, Saplaouras, Athanasios, Letsas, Konstantinos P, Liu, Tong and Tse, Gary 2023. The role of electrophysiological study in the risk stratification of Brugada Syndrome. Cardiology in Review. https://doi.org/10.1097/CRD.0000000000000561
Metformin use and mortality in Asian, diabetic patients with prostate cancer on androgen deprivation therapy: A population-based study
Yan Hiu Athena Lee, Jeremy Man Ho Hui, Jeffrey Shi Kai Chan, Kang Liu, Edward C. Dee, Kenrick Ng, Pias Tang and Tse, G. 2023. Metformin use and mortality in Asian, diabetic patients with prostate cancer on androgen deprivation therapy: A population-based study. The Prostate. 83 (1), pp. 119-127. https://doi.org/10.1002/pros.24443
Predictive value of neutrophil-to-lymphocyte ratio for atrial fibrillation and stroke in type 2 diabetes mellitus: The Hong Kong Diabetes Study
Carlin Chang, Jiandong Zhou, Oscar Hou In Chou, Justin Chan, Keith Sai Kit Leung, Teddy Tai Loy Lee, Wing Tak Wong, Abraham Ka Chung Wai, Tong Liu, Qingpeng Zhang, Sharen Lee and Tse, G. 2023. Predictive value of neutrophil-to-lymphocyte ratio for atrial fibrillation and stroke in type 2 diabetes mellitus: The Hong Kong Diabetes Study. Endocrinology, Diabetes & Metabolism. https://doi.org/10.1002/edm2.397
Socioeconomic deprivation and prognostic outcomes in acute coronary syndrome: A meta-analysis using multidimensional socioeconomic status indices.
Anand, Vickram Vijay, Zhe, Ethan Lee Cheng, Chin, Yip Han, Goh, Rachel Sze Jen, Lin, Chaoxing, Kueh, Martin Tze Wah, Chong, Bryan, Kong, Gwyneth, Tay, Phoebe Wen Lin, Dalakoti, Mayank, Muthiah, Mark, Dimitriadis, Georgios K, Wang, Jiong-Wei, Mehta, Anurag, Foo, Roger, Tse, Gary, Figtree, Gemma A, Loh, Poay Huan, Chan, Mark Y, Mamas, Mamas A and Chew, Nicholas W S 2023. Socioeconomic deprivation and prognostic outcomes in acute coronary syndrome: A meta-analysis using multidimensional socioeconomic status indices. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2023.04.042
Long-term cardiovascular risks of Gonadotropin-releasing hormone agonists and antagonists: A population-based cohort study
Chan, J S K, Lee, Y H A, Hui, J M H, Liu, K, Dee, E C, Ng, K, Tang, P, Tse, G and Ng, C F 2023. Long-term cardiovascular risks of Gonadotropin-releasing hormone agonists and antagonists: A population-based cohort study. Clinical Oncology (Royal College of Radiologists (Great Britain)). 35 (6), pp. e376-e383. https://doi.org/10.1016/j.clon.2023.03.014
Association between sick sinus syndrome and atrial fibrillation: A systematic review and meta-analysis.
Liu, Ying, Zheng, Yi, Tse, Gary, Bazoukis, George, Letsas, Konstantinos, Goudis, Christos, Korantzopoulos, Panagiotis, Li, Guangping and Liu, Tong 2023. Association between sick sinus syndrome and atrial fibrillation: A systematic review and meta-analysis. International Journal of Cardiology. 381, pp. 20-36. https://doi.org/10.1016/j.ijcard.2023.03.066
Comparing sodium-glucose cotransporter 2 inhibitors and dipeptidyl peptidase-4 inhibitors on new-onset depression: a propensity score-matched study in Hong Kong.
Mui, Jonathan V, Li, Lifang, Chou, O., Azfar, Nida, Lee, Athena, Hui, Jeremy, Lee, Sharen, Tse, Gary and Zhou, Jiandong 2023. Comparing sodium-glucose cotransporter 2 inhibitors and dipeptidyl peptidase-4 inhibitors on new-onset depression: a propensity score-matched study in Hong Kong. Acta Diabetologica. https://doi.org/10.1007/s00592-023-02063-6
Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin‐induced myocardial injury
Zhang, Q., Zhang, Y., Xie, Bingxin, Liu, Daiqi, Wang, Yueying, Zhou, Zandong, Zhang, Yue, King, Emma, Tse, Gary and Liu, T. 2023. Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin‐induced myocardial injury. Cancer Innovation. 2 (4), pp. 253-264. https://doi.org/10.1002/cai2.64
Long-term atherosclerotic cardiovascular disease risk in patients with cancer: a population-based study.
Yang, Ling, Zhang, Nan, Yue, Qing, Song, Wenhua, Zheng, Yi, Huang, Shan, Qiu, Jiuchun, Tse, Gary, Li, Guangping, Wu, Shouling and Liu, Tong 2023. Long-term atherosclerotic cardiovascular disease risk in patients with cancer: a population-based study. Current Problems in Cardiology. https://doi.org/10.1016/j.cpcardiol.2023.101693
Arrhythmias beyond atrial fibrillation detection using smartwatches: A systematic review
Pay, Levent, Yumurtaş, Ahmet Çağdaş, Satti, Danish Iltaf, Hui, Jeremy Man Ho, Chan, Jeffrey Shi Kai, Mahalwar, Gauranga, Lee, Yan Hiu Athena, Tezen, Ozan, Birdal, Oğuzhan, Inan, Duygu, Özkan, Eyup, Tse, Gary and Çinier, Göksel 2023. Arrhythmias beyond atrial fibrillation detection using smartwatches: A systematic review. Anatolian Journal of Cardiology. 27 (3), pp. 126-131. https://doi.org/10.14744/AnatolJCardiol.2023.2799
Application of artificial intelligence in the diagnosis of sleep apnea
Bazoukis, George, Bollepalli, Sandeep Chandra, Chung, Cheuk To, Li, Xinmu, Tse, Gary, Bartley, Bethany L, Batool-Anwar, Salma, Quan, Stuart F and Armoundas, Antonis A 2023. Application of artificial intelligence in the diagnosis of sleep apnea. Journal of Clinical Sleep Medicine. 19 (7), pp. 1337-1363. https://doi.org/10.5664/jcsm.10532
Association between immune checkpoint inhibitors and myocardial infarction in Asians: A population‐based self‐controlled case series
Chan, J., Tang, Pias, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Y., Li, Guoliang, Leung, Fung Ping, Wong, Wing Tak, Liu, T. and Tse, Gary 2023. Association between immune checkpoint inhibitors and myocardial infarction in Asians: A population‐based self‐controlled case series. Cancer Medicine. 12 (8), pp. 9541-9546. https://doi.org/10.1002/cam4.5729
Influenza and pneumococcal vaccine prescription for adults during COVID-19 first wave in three regions of Argentina.
Matta, María Gabriela, Pulido, Laura, Herrera-Paz, Juan José, Picco, José M, Wolff, Sebastian, Tse, Gary and Garcia-Zamora, Sebastian 2023. Influenza and pneumococcal vaccine prescription for adults during COVID-19 first wave in three regions of Argentina. Vaccine. 41 (9), pp. 1541-1544. https://doi.org/10.1016/j.vaccine.2023.01.056
Radiotherapy-induced malfunctions of cardiac implantable electronic devices: a meta-analysis
Xu, Beizheng, Wang, Yueying, Tse, Gary, Chen, Jiayi, Li, Guangping, Korantzopoulos, Panagiotis and Liu, Tong 2023. Radiotherapy-induced malfunctions of cardiac implantable electronic devices: a meta-analysis. Heart Rhythm. 20 (5), pp. 689-698. https://doi.org/10.1016/j.hrthm.2023.01.024
Lower risks of incident colorectal cancer in SGLT2i users compared to DPP4i users: A propensity score-matched study with competing risk analysis.
Chan, Raymond Ngai Chiu, Chan, Robert Ngai Fung, Chou, Oscar Hou In, Tse, Gary and Lee, Sharen 2023. Lower risks of incident colorectal cancer in SGLT2i users compared to DPP4i users: A propensity score-matched study with competing risk analysis. European Journal of Internal Medicine. https://doi.org/S0953-6205(23)00026-2
Effectiveness and safety of transcatheter aortic valve replacement in elderly people with severe aortic stenosis with different types of heart failure.
Dong, Mei, Wang, Lizhen, Tse, Gary, Dai, Tao, Wang, Lihong, Xiao, Zhicheng, Liu, Tong and Ren, Faxin 2023. Effectiveness and safety of transcatheter aortic valve replacement in elderly people with severe aortic stenosis with different types of heart failure. BMC Cardiovascular Disorders. 23 (1), p. 34. https://doi.org/10.1186/s12872-023-03048-7
Risk of diabetes mellitus among users of immune checkpoint inhibitors: A population‐based cohort study
Chan, J., Lee, Sharen, Kong, Dicken, Lakhani, I., Ng, Kenrick, Dee, E., Tang, Pias, Lee, Y., Satti, Danish Iltaf, Wong, Wing Tak, Liu, T. and Tse, Gary 2023. Risk of diabetes mellitus among users of immune checkpoint inhibitors: A population‐based cohort study. Cancer Medicine. 12 (7), pp. 8144-8153. https://doi.org/10.1002/cam4.5616
Prediction of the presence of ventricular fibrillation from a Brugada electrocardiogram using artificial intelligence
Tse, Gary, Lee, Sharen and Liu, Tong 2023. Prediction of the presence of ventricular fibrillation from a Brugada electrocardiogram using artificial intelligence. Circulation Journal : Official Journal of the Japanese Circulation Society. 87 (7), p. 1015. https://doi.org/10.1253/circj.cj-22-0792
Association of proteinuria and risk of incident atrial fibrillation in the general population: A prospective study of Kailuan study participants
Li, Jie, Wang, Yueying, Qi, Wenwei, Zhang, Nan, Tse, Gary, Li, G., Wu, Shouling and Liu, Tong 2023. Association of proteinuria and risk of incident atrial fibrillation in the general population: A prospective study of Kailuan study participants. Pacing and Clinical Electrophysiology. 46 (6), pp. 526-534. https://doi.org/10.1111/pace.14658
Arrhythmias and conduction disturbances in patients with systemic sclerosis—A systematic literature review
Vrancianu, Cristina Andreea, Gheorghiu, A., Popa, Dragos Emanuel, Chan, J., Satti, D., Lee, Yan Hiu Athena, Hui, J., Tse, G., Ancuta, Ioan, Ciobanu, Ana and Bojinca, Mihai 2022. Arrhythmias and conduction disturbances in patients with systemic sclerosis—A systematic literature review. International Journal of Molecular Sciences. 23 (21), p. 12963. https://doi.org/10.3390/ijms232112963
Role of heat shock proteins in atrial fibrillation: From molecular mechanisms to diagnostic and therapeutic opportunities
Liu, D., Han, X., Zhang, Z., Tse, G., Shao, Q. and Liu, T. 2022. Role of heat shock proteins in atrial fibrillation: From molecular mechanisms to diagnostic and therapeutic opportunities. Cells. https://doi.org/10.3390/cells12010151
Retinal microvascular abnormalities predict clinical outcomes in patients with heart failure
Guo, Shaohua, Yin, Songtao, Song, Wenhua, Tse, Gary, Liu, Juping, Hei, Kaiwen, Chen, Kangyin, Su, Long and Liu, Tong 2022. Retinal microvascular abnormalities predict clinical outcomes in patients with heart failure. Diagnostics. 12 (9), p. 2078. https://doi.org/10.3390/diagnostics12092078
Clinical characteristics, genetic findings and arrhythmic outcomes of patients with catecholaminergic polymorphic ventricular tachycardia from China: A systematic review
Leung, J., Lee, S., Zhou, J., Jeevaratnam, K., Lakhani, I., Radford, D., Coakley-Youngs, Emma, Pay, Levent, Çinier, G., Altinsoy, M., Behnoush, A., Mahmoudi, E., Matusik, P., Bazoukis, G., Garcia-Zamora, S., Zeng, S., Chen, Z., Xia, Y., Liu, T. and Tse, G. 2022. Clinical characteristics, genetic findings and arrhythmic outcomes of patients with catecholaminergic polymorphic ventricular tachycardia from China: A systematic review. Life. 12 (8), p. 1104. https://doi.org/10.3390/life12081104
Heterogeneities in ventricular conduction following treatment with heptanol: A multi-electrode array study in Langendorff-Perfused mouse hearts
Dong, X., Tse, G., Hao, G. and Du, Y. 2022. Heterogeneities in ventricular conduction following treatment with heptanol: A multi-electrode array study in Langendorff-Perfused mouse hearts. Life. 12 (7), p. 996. https://doi.org/10.3390/life12070996
Stereotactic radiotherapy: An alternative option for refractory ventricular tachycardia to drug and ablation therapy
Shangguan, Wenfeng, Xu, Gang, Wang, Xin, Zhang, Nan, Liu, Xingpeng, Li, Guangping, Tse, G. and Liu, Tong 2022. Stereotactic radiotherapy: An alternative option for refractory ventricular tachycardia to drug and ablation therapy. Journal of Clinical Medicine. 11 (12), p. 3549. https://doi.org/10.3390/jcm11123549
Endothelial-derived APT1-mediated macrophage-endothelial cell interactions participate in the development of atherosclerosis by regulating the Ras/MAPK signaling pathway
Wang, Xinghua, Cheng, Lijun, Fu, Huaying, Chan, Calista Zhuo Yi, Tse, Gary, Liu, Tong and Li, Guangping 2022. Endothelial-derived APT1-mediated macrophage-endothelial cell interactions participate in the development of atherosclerosis by regulating the Ras/MAPK signaling pathway. Life. 12 (4), p. 551. https://doi.org/10.3390/life12040551
Adverse Cardiovascular Complications following prescription of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: a propensity-score matched Cohort Study with competing risk analysis
Jiandong Zhou, Sharen Lee, Ishan Lakhani, Lei Yang, Tong Liu, Yuhui Zhang, Yunlong Xia, Wing Tak Wong, Kelvin King Hei Bao, Ian Chi Kei Wong, Gary Tse and Qingpeng Zhang 2022. Adverse Cardiovascular Complications following prescription of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: a propensity-score matched Cohort Study with competing risk analysis. Cardio-oncology (London, England). https://doi.org/10.1186/s40959-021-00128-5
Clinical characteristics, risk factors and outcomes of cancer patients with COVID-19: A population-based study
Jiandong Zhou, Ishan Lakhani, Oscar Chou, Keith Sai Kit Leung, Teddy Tai Loy Lee, Michelle Vangi Wong, Zhen Li, Abraham Ka Chung Wai, Carlin Chang, Ian Chi Kei Wong, Qingpeng Zhang, Gary Tse and Bernard Man Yung Cheung 2022. Clinical characteristics, risk factors and outcomes of cancer patients with COVID-19: A population-based study. Cancer Medicine. 12 (1), pp. 287-296. https://doi.org/10.1002/cam4.4888
NADPH oxidase mediates oxidative stress and ventricular remodeling through SIRT3/FOXO3a pathway in diabetic mice
Jiuchun Qiu, Daiqi Liu, Pengsha Li, Lingling Zhou, Lu Zhou, Xing Liu, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li and Tong Liu 2022. NADPH oxidase mediates oxidative stress and ventricular remodeling through SIRT3/FOXO3a pathway in diabetic mice. Antioxidants. 11 (9), p. 1745. https://doi.org/10.3390/antiox11091745
A territory-wide Study of arrhythmogenic right ventricular cardiomyopathy patients from Hong Kong
Ishan Lakhani, Jiandong Zhou, Sharen Lee, Ka Hou Christien Li, Keith Sai Kit Leung, Jeremy Man Ho Hui, Yan Hiu Athena Lee, Guoliang Li, Tong Liu, Wing Tak Wong, Ian Chi Kei Wong, Ngai Shing Mok, Chloe Miu Mak, Qingpeng Zhang and Gary Tse 2022. A territory-wide Study of arrhythmogenic right ventricular cardiomyopathy patients from Hong Kong. Reviews in Cardiovascular Medicine. 23 (7), p. 231. https://doi.org/10.31083/j.rcm2307231
Clinical characteristics, genetic basis and healthcare resource utilisation and costs in patients with catecholaminergic polymorphic ventricular tachycardia: A retrospective cohort study
Cheuk To Chung, Sharen Lee, Jiandong Zhou, Oscar Hou In Chou, Teddy Tai Loy Lee, Keith Sai Kit Leung, Kamalan Jeevaratnam, Wing Tak Wong, Tong Liu and Gary Tse 2022. Clinical characteristics, genetic basis and healthcare resource utilisation and costs in patients with catecholaminergic polymorphic ventricular tachycardia: A retrospective cohort study. Reviews in Cardiovascular Medicine. 23 (8).
Clinical significance, challenges and limitations in using artificial intelligence for electrocardiography-based diagnosis
Cheuk To Chung, Sharen Lee, Emma King, Tong Liu, Antonis A. Armoundas, George Bazoukis and Gary Tse 2022. Clinical significance, challenges and limitations in using artificial intelligence for electrocardiography-based diagnosis. International Journal of Arrhythmia. 23. https://doi.org/10.1186/s42444-022-00075-x
Machine learning techniques for arrhythmic risk stratification: a review of the literature
Cheuk To Chung, George Bazoukis, Sharen Lee, Ying Liu, Tong Liu, Konstantinos P. Letsas, Antonis A. Armoundas and Gary Tse 2022. Machine learning techniques for arrhythmic risk stratification: a review of the literature. International Journal of Arrhythmia. 23.
Risk factors of pancreatic cancer in patients with type 2 diabetes mellitus: The Hong Kong Diabetes Study
Raymond Ngai Chiu Chan, Teddy Tai Loy Lee, Oscar Hou In Chou, Jenny So, Cheuk To Chung, Edward Christopher Dee, Kenrick Ng, Pias Tang, Leonardo Roever, Tong Liu, Wing Tak Wong, Gary Tse and Sharen Lee 2022. Risk factors of pancreatic cancer in patients with type 2 diabetes mellitus: The Hong Kong Diabetes Study. Journal of the Endocrine Society. 6 (11). https://doi.org/10.1210/jendso/bvac138
The role of late gadolinium enhancement in predicting arrhythmic events in cardiac sarcoidosis patients – a mini-review
George Bazoukis, Ioannis Liatakis, Vassilios S. Vassiliou, Gary Tse, Pantelis Gounopoulos, Athanasios Saplaoura, Konstantinos P. Letsas, Konstantinos Vlachos, Stamatis S. Papadatos, Eleni Konstantinidou, Ioannis Lakoumentas, Antonios Sideris and Michael Efremidis 2022. The role of late gadolinium enhancement in predicting arrhythmic events in cardiac sarcoidosis patients – a mini-review. Acta Cardiologica. 77 (9). https://doi.org/10.1080/00015385.2022.2029231
Association between sodium-glucose cotransporter-2 inhibitors and risk of sudden cardiac death or ventricular arrhythmias: a meta-analysis of randomized controlled trials
Dimitrios Sfairopoulos, Nan Zhang, Yueying Wang, Ziliang Chen, Konstantinos P Letsas, Gary Tse, Guangping Li, Gregory Y H Lip, Tong Liu and Panagiotis Korantzopoulos 2022. Association between sodium-glucose cotransporter-2 inhibitors and risk of sudden cardiac death or ventricular arrhythmias: a meta-analysis of randomized controlled trials. EP Europace. 24 (1), pp. 20-30. https://doi.org/10.1093/europace/euab177
Comparison of sodium-glucose cotransporter-2 inhibitor and dipeptidyl peptidase-4 inhibitor on the risks of new-onset atrial fibrillation, stroke and mortality in diabetic patients: A propensitysScore-matched study in Hong Kong
Sharen Lee, Jiandong Zhou, Keith Sai Kit Leung, Abraham Ka Chung Wai, Kamalan Jeevaratnam, Emma King, Tong Liu, Wing Tak Wong, Carlin Chang, Ian Chi Kei Wong, Bernard Man Yung Cheung, Gary Tse and Qingpeng Zhang 2022. Comparison of sodium-glucose cotransporter-2 inhibitor and dipeptidyl peptidase-4 inhibitor on the risks of new-onset atrial fibrillation, stroke and mortality in diabetic patients: A propensitysScore-matched study in Hong Kong. Cardiovascular Drugs and Therapy. 37, pp. 561-569. https://doi.org/10.1007/s10557-022-07319-x
Incident heart failure and myocardial infarction in sodium-glucose cotransporter-2 vs. dipeptidyl peptidase-4 inhibitor users
Jiandong Zhou, Sharen Lee, Keith Sai Kit Leung, Abraham Ka Chung Wai, Tong Liu, Ying Liu, Dong Chang, Wing Tak Wong, Ian Chi Kei Wong, Bernard Man Yung Cheung, Qingpeng Zhang and Gary Tse 2022. Incident heart failure and myocardial infarction in sodium-glucose cotransporter-2 vs. dipeptidyl peptidase-4 inhibitor users. ESC Heart Failure. 9 (2), pp. 1388-1399.
IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling
Tse, G. 2022. IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling. Redox Biology. 52, p. 102289. https://doi.org/10.1016/j.redox.2022.102289
Mass screening for low bone density using basic check-up items
Zhongzhi Xu, Weibin Cheng, Zhen Li, Gary Tse, Fengshi Jing, Wanmin Lian, Junzhang Tian and Qingpeng Zhang 2022. Mass screening for low bone density using basic check-up items. IEEE Transactions on Computational Social Systems . pp. 1-8.
Sulfonylurea is associated with higher risks of ventricular arrhythmia or sudden cardiac death compared with metformin: A population-based cohort study
Teddy Tai Loy Lee, Jeremy Man Ho Hui, Yan Hiu Athena Lee, Danish Iltaf Satti, Yuki Ka Ling Shum, Pias Tang Hoi Kiu, Abraham Ka Chung Wai, Tong Liu, Wing Tak Wong, Jeffrey Shi Kai Chan, Bernard Man Yung Cheung, Ian Chi Kei Wong, Shuk Han Cheng and Gary Tse 2022. Sulfonylurea is associated with higher risks of ventricular arrhythmia or sudden cardiac death compared with metformin: A population-based cohort study. Journal of the American Heart Association. 2022 (11), p. e026289.
High visit-to-visit cholesterol variability predicts heart failure and adverse cardiovascular events: a population-based cohort study
Jeffrey Shi Kai Chan, Danish Iltaf Satti, Yan Hiu Athena Lee, Jeremy Man Ho Hui, Teddy Tai Loy Lee, Oscar Hou In Chou, Abraham Ka Chung Wai, Ana Ciobanu, Ying Liu, Tong Liu, Leonardo Roever, Giuseppe Biondi-Zoccai, Qingpeng Zhang, Bernard Man Yung Cheung, Jiandong Zhou and Gary Tse 2022. High visit-to-visit cholesterol variability predicts heart failure and adverse cardiovascular events: a population-based cohort study. European Journal of Preventive Cardiology. 29 (14), pp. e323-e325. https://doi.org/10.1093/eurjpc/zwac097
Association between atherosclerosis-related cardiovascular disease and uveitis: A systematic review and meta-analysis
Gao, Xinyi, Lv, Tonglian, Li, Guangping, Tse, G. and Liu, T. 2022. Association between atherosclerosis-related cardiovascular disease and uveitis: A systematic review and meta-analysis. Diagnostics. 12 (12), p. 3178. https://doi.org/2075-4418/12/12/3178
Association between duration of gonadotrophin-releasing hormone agonist use and cardiovascular risks: A population-based competing-risk analysis
Jeffrey S. K. Chan, Pias Tang, Jeremy M. Ho Hui, Yan H. A. Lee, Edward C. Dee, Kenrick, Kang Liu, Gary Tse and Chi Fai Ng 2022. Association between duration of gonadotrophin-releasing hormone agonist use and cardiovascular risks: A population-based competing-risk analysis. The Prostate. 82 (15), pp. 1477-1480. https://doi.org/10.1002/pros.24423
The impact of cardiac comorbidity sequence at baseline and mortality risk in type 2 diabetes mellitus: A retrospective population-based cohort study
Lee, Sharen, Huang, H., Lee, Teddy Tai Loy, Chung, Cheuk To, Chou, O., Leung, K., Wai, A., Wong, Wing Tak, Liu, T., Chang, Carlin and Tse, G. 2022. The impact of cardiac comorbidity sequence at baseline and mortality risk in type 2 diabetes mellitus: A retrospective population-based cohort study. Life. 12 (12), p. 1956. https://doi.org/10.3390/life12121956
P-wave durations from automated electrocardiogram analysis to predict atrial fibrillation and mortality in heart failure
Jiandong Zhou, Andrew Li, Martin Tan, Matthew Chung Yan Lam, Lok Tin Hung, Ronald Wing Hei Siu, Sharen Lee, Ishan Lakhani, Jeffrey Shi Kai Chan, Khalid Bin Waleed, Tong Liu, Kamalan Jeevaratnam, Qingpeng Zhang and Tse, G. 2022. P-wave durations from automated electrocardiogram analysis to predict atrial fibrillation and mortality in heart failure. ESC Heart Failure.
Long-term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy
Tse, G. 2022. Long-term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy. European Journal of Clinical Investigation.
Electrocardiogram-based artificial intelligence for the diagnosis of heart failure: a systematic review and meta-analysis.
Li, Xin-Mu, Gao, Xin-Yi, Tse, Gary, Hong, Shen-Da, Chen, Kang-Yin, Li, Guang-Ping and Liu, Tong 2022. Electrocardiogram-based artificial intelligence for the diagnosis of heart failure: a systematic review and meta-analysis. Journal of Geriatric Cardiology : JGC. 19 (12), pp. 970-980. https://doi.org/10.11909/j.issn.1671-5411.2022.12.002
HbA1c variability and cardiovascular events in patients with prostate cancer receiving androgen deprivation therapy
Chan, Jeffrey Shi Kai, Lee, Yan Hiu Athena, Liu, Kang, Hui, Jeremy Man Ho, Dee, Edward Christopher, Ng, Kenrick, Satti, Danish Iltaf, Liu, Tong, Tse, Gary and Ng, Chi Fai 2022. HbA1c variability and cardiovascular events in patients with prostate cancer receiving androgen deprivation therapy. European Urology Open Science. 47, pp. 3-11. https://doi.org/10.1016/j.euros.2022.11.002
Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome
Chen, Gan-Xiao, Barajas-Martínez, Hector, Ciconte, Giuseppe, Wu, Cheng-I, Monasky, Michelle M, Xia, Hao, Li, Bian, Capra, John A, Guo, Kai, Zhang, Zhong-He, Chen, Xiu, Yang, Bo, Jiang, Hong, Tse, Gary, Mak, Chloe Miu, Aizawa, Yoshiyasu, Gollob, Michael H, Antzelevitch, Charles, Wilde, Arthur A M, Pappone, Carlo and Hu, Dan 2022. Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome. EBioMedicine. 87, p. 104388. https://doi.org/10.1016/j.ebiom.2022.104388
Efficacy of guideline-directed medical treatment in heart failure with mildly reduced ejection fraction.
Zhang, Xinxin, Sun, Yuxi, Zhang, Yunlong, Wang, Ning, Sha, Qiuyan, Yu, Songqi, Lv, Xin, Ding, Zijie, Zhang, Yanli, Tse, Gary and Liu, Ying 2022. Efficacy of guideline-directed medical treatment in heart failure with mildly reduced ejection fraction. ESC Heart Failure. https://doi.org/10.1002/ehf2.14199
Cardiovascular toxicity of proteasome inhibitors in multiple myeloma therapy
Zheng, Yi, Huang, Shan, Xie, Bingxin, Zhang, Nan, Liu, Zhiqiang, Tse, Gary and Liu, Tong 2022. Cardiovascular toxicity of proteasome inhibitors in multiple myeloma therapy. Current Problems in Cardiology. 48 (3), p. 101536. https://doi.org/10.1016/j.cpcardiol.2022.101536
PD-1/PD-L1 blockade accelerates the progression of atherosclerosis in cancer patients
Dong, Mei, Yu, Ting, Tse, Gary, Lin, Zerun, Lin, Chen, Zhang, Nan, Wang, Rujian, Liu, Tong and Zhong, Lin 2022. PD-1/PD-L1 blockade accelerates the progression of atherosclerosis in cancer patients. Current Problems in Cardiology. 51, p. 101527. https://doi.org/10.1016/j.cpcardiol.2022.101527
Attendance-related healthcare resource utilisation and costs in patients with Brugada Syndrome in Hong Kong: A retrospective cohort study.
Lee, Sharen, Chung, Cheuk To, Chou, Oscar Hou In, Lee, Teddy Tai Loy, Radford, Danny, Jeevaratnam, Kamalan, Wong, Wing Tak, Cheng, Shuk Han, Mok, Ngai Shing, Liu, Tong and Tse, Gary 2022. Attendance-related healthcare resource utilisation and costs in patients with Brugada Syndrome in Hong Kong: A retrospective cohort study. Current Problems in Cardiology. 48 (2), p. 101513. https://doi.org/10.1016/j.cpcardiol.2022.101513
Electrocardiographic features of immune checkpoint inhibitor-associated myocarditis.
Song, Wenhua, Zheng, Yi, Dong, Mei, Zhong, Lin, Bazoukis, George, Perone, Francesco, Li, Guangping, Ng, Chi Fai, Baranchuk, Adrian, Tse, Gary and Liu, Tong 2022. Electrocardiographic features of immune checkpoint inhibitor-associated myocarditis. Current Problems in Cardiology. 48 (2), p. 101478. https://doi.org/S0146-2806(22)00375-9
Predicting acute onset of heart failure complicating acute coronary syndrome: an explainable machine learning approach
Ren, Hao, Sun, Yu, Xu, Chenyu, Fang, Ming, Xu, Zhongzhi, Jing, Fengshi, Wang, Weilan, Tse, Gary, Zhang, Qingpeng, Cheng, Weibin and Jin, Wen 2022. Predicting acute onset of heart failure complicating acute coronary syndrome: an explainable machine learning approach. Current Problems in Cardiology. 48 (2), p. 101480. https://doi.org/10.1016/j.cpcardiol.2022.101480
Cardiovascular risks of chemo-immunotherapy for lung cancer: A population-based cohort study.
Chan, Jeffrey Shi Kai, Tang, Pias, Ng, Kenrick, Dee, Edward Christopher, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Lau, Dawnie Ho Hei, Liu, Tong and Tse, Gary 2022. Cardiovascular risks of chemo-immunotherapy for lung cancer: A population-based cohort study. Lung cancer (Amsterdam, Netherlands). 174, pp. 67-70. https://doi.org/10.1016/j.lungcan.2022.10.010
Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis.
Li, Xintao, Chan, Jeffrey Shi Kai, Guan, Bo, Peng, Shi, Wu, Xiaoyu, Lu, Xiaofeng, Zhou, Jiandong, Hui, Jeremy Man Ho, Lee, Yan Hiu Athena, Satti, Danish Iltaf, Tsang, Shek Long, Wu, Shouling, Chen, Songwen, Tse, Gary and Liu, Shaowen 2022. Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis. Cardiovascular Diabetology. 21 (1), p. 229. https://doi.org/10.1186/s12933-022-01658-7
Association between sodium-glucose cotransporter-2 inhibitors and incident atrial fibrillation/atrial flutter in heart failure patients with reduced ejection fraction: a meta-analysis of randomized controlled trials.
Sfairopoulos, Dimitrios, Liu, Tong, Zhang, Nan, Tse, Gary, Bazoukis, George, Letsas, Konstantinos, Goudis, Christos, Milionis, Haralampos, Vrettos, Apostolos and Korantzopoulos, P. 2022. Association between sodium-glucose cotransporter-2 inhibitors and incident atrial fibrillation/atrial flutter in heart failure patients with reduced ejection fraction: a meta-analysis of randomized controlled trials. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10281-3
Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.
Satti, Danish Iltaf, Lee, Yan Hiu Athena, Leung, Keith Sai Kit, Hui, Jeremy Man Ho, Kot, Thompson Ka Ming, Babar, Arslan, Mahalwar, Gauranga, Wai, Abraham Kc, Liu, Tong, Roever, Leonardo, Tse, Gary and Chan, Jeffrey Shi Kai 2022. Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. Journal of Geriatric Cardiology : JGC. 19 (9), pp. 705-711. https://doi.org/10.11909/j.issn.1671-5411.2022.09.002
Predicting stroke and mortality in mitral regurgitation: A machine learning approach
Zhou, Jiandong, Lee, Sharen, Liu, Yingzhi, Chan, Jeffrey Shi Kai, Li, Guoliang, Wong, Wing Tak, Jeevaratnam, Kamalan, Cheng, Shuk Han, Liu, Tong, Tse, Gary and Zhang, Qingpeng 2022. Predicting stroke and mortality in mitral regurgitation: A machine learning approach. Current Problems in Cardiology. 48 (2), p. 101464. https://doi.org/S0146-2806(22)00361-9
Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial.
Anjos, J., Neto, Mansueto Gomes, de Araújo Tapparelli, Yuri, Tse, Gary, Biondi-Zoccai, Giuseppe, de Souza Lima Bitar, Yasmin, Roever, Leonardo and Duraes, Andre Rodrigues 2022. Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial. Journal of Neurology. https://doi.org/10.1007/s00415-022-11411-5
Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings.
Bazoukis, George, Garcia-Zamora, Sebastian, Çinier, Göksel, Lee, Sharen, Elvin Gul, Enes, Álvarez-García, Jesús, Miana, Gabi, Hayıroğlu, Mert İlker, Tse, Gary, Liu, Tong and Baranchuk, Adrian 2022. Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings. World Journal of Cardiology. 14 (9), pp. 483-495. https://doi.org/10.4330/wjc.v14.i9.483
Association between visit-to-visit lipid variability and incident cancer: a population-based cohort study.
Chan, Jeffrey Shi Kai, Satti, Danish Iltaf, Lee, Yan Hiu Athena, Waleed, Khalid Bin, Tang, Pias, Mahalwar, Gauranga, Minhas, Abdul Mannan Khan, Roever, Leonardo, Biondi-Zoccai, Giuseppe, Leung, Fung Ping, Wong, Wing Tak, Liu, Tong, Zhou, Jiandong and Tse, Gary 2022. Association between visit-to-visit lipid variability and incident cancer: a population-based cohort study. Current Problems in Cardiology. 48 (1). https://doi.org/10.1016/j.cpcardiol.2022.101421
Syncope prediction scores in the Emergency Department
Liu, Tong, Liang, Yan, Li, Xiulian, Tse, Gary, King, Emma, Roever, Leonardo and Li, Guangping 2022. Syncope prediction scores in the Emergency Department. Current Cardiology Reviews. 18 (5). https://doi.org/10.2174/1573403x18666220321104129
Comparing the performance of published risk scores in Brugada syndrome: a multi-center cohort study.
Lee, Sharen, Zhou, Jiandong, Chung, Cheuk To, Lee, Rebecca On Yu, Bazoukis, George, Letsas, Konstantinos P, Wong, Wing Tak, Wong, Ian Chi Kei, Mok, Ngai Shing, Liu, Tong, Zhang, Qingpeng and Tse, Gary 2022. Comparing the performance of published risk scores in Brugada syndrome: a multi-center cohort study. Current Problems in Cardiology. https://doi.org/10.1016/j.cpcardiol.2022.101381
Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes
Zhou, Jiandong, Liu, Xuejin, Chou, Oscar Hou-In, Li, Lifang, Lee, Sharen, Wong, Wing Tak, Zhang, Qingpeng, Chang, Carlin, Liu, Tong, Tse, Gary, Jing, Fengshi and Cheung, Bernard Man Yung 2022. Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes. Rheumatology. https://doi.org/6692704
The role of cardiac magnetic resonance in identifying appropriate candidates for cardiac resynchronization therapy - a systematic review of the literature
Bazoukis, G., Hui, Jeremy Man Ho, Lee, Yan Hiu Athena, Chou, Oscar Hou In, Sfairopoulos, Dimitrios, Vlachos, Konstantinos, Saplaouras, Athanasios, Letsas, Konstantinos P, Efremidis, Michael, Tse, Gary, Vassiliou, Vassilios S and Korantzopoulos, Panagiotis 2022. The role of cardiac magnetic resonance in identifying appropriate candidates for cardiac resynchronization therapy - a systematic review of the literature. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10263-5
Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study
Chan, Jeffrey Shi Kai, Lakhani, Ishan, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Cheung, Yiu Ming, Yeung, Hoi Wa, Tang, Pias, Ng, Kenrick, Dee, Edward Christopher, Liu, Tong, Wong, Wing Tak, Tse, Gary and Leung, Fung Ping 2022. Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study. Current Problems in Cardiology. p. 101380. https://doi.org/10.1016/j.cpcardiol.2022.101380
Atrial cardiomyopathy: from cell to bedside.
Li, Mengmeng, Ning, Yuye, Tse, Gary, Saguner, Ardan M, Wei, Meng, Day, John D, Luo, Guogang and Li, G. 2022. Atrial cardiomyopathy: from cell to bedside. ESC Heart Failure. 9 (6), pp. 3768-3784. https://doi.org/10.1002/ehf2.14089
Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis.
Zheng, Yi, Zhang, Nan, Wang, Yueying, Wang, Feng, Li, Guangping, Tse, Gary and Liu, Tong 2022. Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis. Ageing Research Reviews. 81, p. 101707. https://doi.org/S1568-1637(22)00149-0
Development of an electronic frailty index for predicting mortality and complications analysis in pulmonary hypertension using random survival forest model
Zhou, Jiandong, Chou, Oscar Hou In, Wong, Ka Hei Gabriel, Lee, Sharen, Leung, Keith Sai Kit, Liu, Tong, Cheung, Bernard Man Yung, Wong, Ian Chi Kei, Tse, Gary and Zhang, Qingpeng 2022. Development of an electronic frailty index for predicting mortality and complications analysis in pulmonary hypertension using random survival forest model. Frontiers in Cardiovascular Medicine. 9, p. 735906. https://doi.org/10.3389/fcvm.2022.735906
ICIs-related cardiotoxicity in different types of cancer
Dong, Mei, Yu, Ting, Zhang, Zhenzhen, Zhang, Jing, Wang, Rujian, Tse, Gary, Liu, T. and Zhong, Lin 2022. ICIs-related cardiotoxicity in different types of cancer. Journal of Cardiovascular Development and Disease. 9 (7), p. 203. https://doi.org/10.3390/jcdd9070203
Association of visit-to-visit variability in fasting plasma glucose with digestive cancer risk
Zhang, Nan, Wang, Yueying, Tse, Gary, Li, G., Wu, S. and Liu, T. 2022. Association of visit-to-visit variability in fasting plasma glucose with digestive cancer risk. Oxidative Medicine and Cellular Longevity. 2022, p. 4530894. https://doi.org/10.1155/2022/4530894
Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review.
Bazoukis, G., Tyrovolas, Konstantinos, Letsas, Konstantinos P, Vlachos, Konstantinos, Radford, Danny, Chung, Cheuk To, Liu, Tong, Efremidis, Michael, Tse, Gary and Baranchuk, Adrian 2022. Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10257-3
Risk of new-onset prostate cancer for Metformin versus Sulfonylurea use in Type 2 Diabetes Mellitus: A propensity score-matched study
Lee, Yan Hiu Athena, Zhou, Jiandong, Hui, Jeremy Man Ho, Liu, Xuejin, Lee, Teddy Tai Loy, Hui, Kyle, Chan, Jeffrey Shi Kai, Wai, Abraham Ka Chung, Wong, Wing Tak, Liu, Tong, Ng, Kenrick, Lee, Sharen, Dee, Edward Christopher, Zhang, Qingpeng and Tse, Gary 2022. Risk of new-onset prostate cancer for Metformin versus Sulfonylurea use in Type 2 Diabetes Mellitus: A propensity score-matched study. Journal of the National Comprehensive Cancer Network. 20 (6), pp. 674-682.e15. https://doi.org/10.6004/jnccn.2022.7010
Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics
Zhang, Nan, Wang, Yueying, Chen, Ziliang, Liu, Daiqi, Tse, Gary, Korantzopoulos, Panagiotis, Letsas, Konstantinos P., Goudis, Christos A., Lip, Gregory Y. H., Li, Guangping, Zhang, Zhiwei and Liu, Tong 2022. Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics. Frontiers in Nutrition. 9, p. 842392. https://doi.org/10.3389/fnut.2022.842392
A remote mentorship model for empowering students to undertake electrocardiology research: Effects on gender equity.
Nam, Ronald Hang Kin, Tse, Gary, Liu, Tong, Jeevaratnam, Kamalan and Lee, Sharen 2022. A remote mentorship model for empowering students to undertake electrocardiology research: Effects on gender equity. Journal of Electrocardiology. 72, pp. 128-130. https://doi.org/S0022-0736(22)00058-9
Editorial: Risk stratification strategies for cardiac rhythm abnormalities
Tse, Gary, Zhang, Nan, Song, Wenhua, Letsas, Konstantinos P., Ngarmukos, Tachapong, Jeevaratnam, Kamalan and Liu, Tong 2022. Editorial: Risk stratification strategies for cardiac rhythm abnormalities. Frontiers in Cardiovascular Medicine. 9, p. 887461. https://doi.org/10.3389/fcvm.2022.887461
C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies.
Li, Xintao, Peng, Shi, Wu, Xiaoyu, Guan, Bo, Tse, Gary, Chen, Songwen, Zhou, Genqing, Wei, Yong, Gong, Chao, Lu, Xiaofeng, Xu, Juan, Wu, Shouling and Liu, Shaowen 2022. C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies. Nutrition, metabolism, and cardiovascular diseases : NMCD. https://doi.org/S0939-4753(22)00130-2
Pathogenesis and management of Brugada Syndrome: Recent advances and protocol for umbrella reviews of meta-analyses in major arrhythmic events risk stratification
Aziz, H., Zarzecki, Michał P, Garcia-Zamora, Sebastian, Kim, Min Seo, Bijak, Piotr, Tse, Gary, Won, Hong-Hee and Matusik, P. 2022. Pathogenesis and management of Brugada Syndrome: Recent advances and protocol for umbrella reviews of meta-analyses in major arrhythmic events risk stratification. Journal of Clinical Medicine. 11 (7), p. 1912. https://doi.org/jcm11071912
Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study.
Chou, O., Zhou, Jiandong, Lee, Teddy Tai Loy, Kot, Thompson, Lee, Sharen, Wai, Abraham Ka Chung, Wong, Wing Tak, Zhang, Qingpeng, Cheng, Shuk Han, Liu, Tong, Vassiliou, Vassilios S, Cheung, Bernard Man Yung and Tse, Gary 2022. Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study. Clinical Research in Cardiology : Official Journal of the German Cardiac Society. https://doi.org/10.1007/s00392-022-02007-0
Liver immune-related adverse effects of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: A propensity score matched study with competing risk analyses
Zhou, J, Chau, Y-L A, Yoo, J W, Lee, S, Ng, K, Dee, E C, Liu, T, Wai, A K C, Zhang, Q and Tse, G 2022. Liver immune-related adverse effects of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: A propensity score matched study with competing risk analyses. Clinical Oncology (Royal College of Radiologists (Great Britain)). https://doi.org/10.1016/j.clon.2022.03.006
EPR22-112: Risk of prostate cancer for Metformin versus Sulphonylurea monotherapy in Type 2 Diabetes Mellitus: A propensity score-matched retrospective cohort study
Lee, Yan Hiu Athena, Zhou, Jiandong, Hui, Jeremy Man Ho, Liu, Xuejin, Lee, Teddy Tai Loy, Hui, Kyle, Wai, Abraham Ka Chung, Wong, Wing Tak, Liu, Tong, Ng, Kenrich, Lee, Sharen, Dee, Edward Christopher, Chan, Jeffrey Shi Kai, Zhang, Qingpeng and Tse, Gary 2022. EPR22-112: Risk of prostate cancer for Metformin versus Sulphonylurea monotherapy in Type 2 Diabetes Mellitus: A propensity score-matched retrospective cohort study. Journal of the National Comprehensive Cancer Network. 20 (3.5), pp. EPR22-112. https://doi.org/10.6004/jnccn.2021.7189
Predictive risk models for forecasting arrhythmic outcomes in Brugada syndrome: A focused review
Chung, Cheuk To, Bazoukis, George, Radford, Danny, Coakley-Youngs, Emma, Rajan, Rajesh, Matusik, Paweł T, Liu, Tong, Letsas, Konstantinos P, Lee, Sharen and Tse, Gary 2022. Predictive risk models for forecasting arrhythmic outcomes in Brugada syndrome: A focused review. Journal of Electrocardiology. 72, pp. 28-34. https://doi.org/10.1016/j.jelectrocard.2022.02.009
Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome
Letsas, Konstantinos P, Vlachos, Konstantinos, Efremidis, Michael, Dragasis, Stylianos, Korantzopoulos, Panagiotis, Tse, Gary, Liu, Tong, Bazoukis, George, Niarchou, Panagioula, Prappa, Efstathia, Sacher, Frederic, Hocini, Meleze and Baranchuk, Adrian 2022. Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome. Reviews in Cardiovascular Medicine. 23 (2), p. 44. https://doi.org/S1530-6550(22)00331-3
A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction
Wang, Weiding, Mu, Guanyu, Liu, Changle, Xie, Juan, Zhang, Hao, Zhang, Xiaowei, Che, Jingjin, Tse, Gary, Liu, Tong, Li, Guangping and Fu, Huaying 2022. A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction. Frontiers in Cardiovascular Medicine. 9, p. 822314. https://doi.org/10.3389/fcvm.2022.822314
Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration.
Chen, Francis M, Tse, Joyce Ky, Jin, Leigang, Chook, Chui Yiu Bamboo, Leung, Fung Ping, Tse, Gary, Woo, Connie W, Xu, Aimin, Chawla, Ajay, Tian, Xiao Yu, Chan, Ting-Fung and Wong, Wing Tak 2022. Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration. Theranostics. 12 (3), pp. 1161-1172. https://doi.org/10.7150/thno.67515
Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies
Duraes, Andre R, Bitar, Yasmin S, Neto, Mansueto G, Mesquita, Evandro T, Chan, Jeffrey S, Tse, Gary, Liu, Tong, Boochi, Edimar A, Biondi-Zoccai, Giuseppe and Roever, Leonardo 2022. Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies. Minerva Medica. https://doi.org/10.23736/S0026-4806.22.08029-6
Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study.
Zhou, Jiandong, Zhang, Guoming, Chang, Carlin, Chou, O., Lee, Sharen, Leung, Keith Sai Kit, Wong, Wing Tak, Liu, Tong, Wai, Abraham Ka Chung, Cheng, Shuk Han, Zhang, Qingpeng and Tse, Gary 2022. Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study. Acta Diabetologica. https://doi.org/10.1007/s00592-021-01841-4
The value of IGF-1 and IGFBP-1 in patients with heart failure with reduced, mid-range, and preserved ejection fraction
Guo, Shaohua, Gong, Mengqi, Tse, Gary, Li, Guangping, Chen, Kang-Yin and Liu, Tong 2022. The value of IGF-1 and IGFBP-1 in patients with heart failure with reduced, mid-range, and preserved ejection fraction. Frontiers in Cardiovascular Medicine. 8, p. 772105. https://doi.org/10.3389/fcvm.2021.772105
Butyrate protects endothelial function through PPARδ/miR-181b signaling
Qinqin Tia, Fung Ping Leung, Francis M. Chen, Xiao Yu Tian, Zhenyu Chen, Gary Tse, Shuangtao Ma and Wing Tak Wong 2021. Butyrate protects endothelial function through PPARδ/miR-181b signaling. Pharmacological Research. 169, p. 105681.
Transcriptional profiles of genes related to electrophysiological function in Scn5a+/− murine hearts
Michael Takla, Charlotte E. Edling, Kevin Zhang, Khalil Saadeh, Gary Tse, Samantha C. Salvage, Christopher L.-H. Huang and Kamalan Jeevaratnam 2021. Transcriptional profiles of genes related to electrophysiological function in Scn5a+/− murine hearts. Physiological Reports. 9 (19), p. e15043. https://doi.org/10.14814/phy2.15043
Diagnostic value of cardiac troponin I and N-terminal pro-B-Type Natriuretic Peptide in cardiac syncope
Yan Liang, Xiulian Li, Gary Tse, Guangping Li, Wenling Liu and Tong Liu 2021. Diagnostic value of cardiac troponin I and N-terminal pro-B-Type Natriuretic Peptide in cardiac syncope. Current Research in Physiology. 4, pp. 24-28. https://doi.org/10.1016/j.crphys.2021.01.003
Right ventricular outflow tract electroanatomical abnormalities in asymptomatic and high-risk symptomatic patients with Brugada syndrome: Evidence for a new risk stratification tool?
Konstantinos P. Letsas, Konstantinos Vlachos, Giulio Conte, Michael Efremidis, Takashi Nakashima, Josselin Duchateau, George Bazoukis, Antonio Frontera, Panagiotis Mililis, Gary Tse, Ghassen Cheniti, Masateru Takigawa, Thomas Pambrun, Efstathia Prappa, Frederic Sacher, Nicolas Derval, Antonios Sideris, Angelo Auricchio, Pierre Jais, Michel Haissaguerre and Meleze Hocini 2021. Right ventricular outflow tract electroanatomical abnormalities in asymptomatic and high-risk symptomatic patients with Brugada syndrome: Evidence for a new risk stratification tool? Journal of Cardiovascular Electrophysiology. 32 (11), pp. 2997-3007. https://doi.org/10.1111/jce.15262
Pairwise feature interactions to predict arrhythmic risk of Brugada Syndrome
Sharen Lee, Jiandong Zhou Konstantinos, Konstantinos P. Letsas, Ka Hou Christien Li, Tong Liu, Sven Zumhagen, Eric Schulze-Bahr, Gary Tse and Qingpeng Zhang 2021. Pairwise feature interactions to predict arrhythmic risk of Brugada Syndrome. IEEE. https://doi.org/10.23919/CinC53138.2021.9662913
Predictive scores for identifying patients with type 2 diabetes mellitus at risk of acute myocardial infarction and sudden cardiac death
Sharen Lee, Jiandong Zhou, Cosmos Liutao Guo, Wing Tak Wong, Tong Liu, Ian Chi Kei Wong, Kamalan Jeevaratnam, Qingpeng Zhang and Gary Tse 2021. Predictive scores for identifying patients with type 2 diabetes mellitus at risk of acute myocardial infarction and sudden cardiac death. Endocrinology, Diabetes & Metabolism. 4 (3), p. e00240.
Risk stratification of cardiac arrhythmias and sudden cardiac death in type 2 diabetes mellitus patients receiving insulin therapy: A population-based cohort study
Sharen Lee, Kamalan Jeevaratnam, Tong Liu, Dong Chang, Carlin Chang, Wing Tak Wong, Ian Chi Kei Wong, Gregory Y. H. Lip and Gary Tse 2021. Risk stratification of cardiac arrhythmias and sudden cardiac death in type 2 diabetes mellitus patients receiving insulin therapy: A population-based cohort study. Clinical Cardiology. 44 (11), p. 2021. https://doi.org/10.1002/clc.23728
Derivation of an electronic frailty index for predicting short-term mortality in heart failure: a machine learning approach
Tse, G., Chengsheng Ju, Jiandong Zhou, Sharen Lee, Martin Sebastian Tan, Tong Liu, George Bazoukis, Kamalan Jeevaratnam, Esther W.Y. Chan, Ian Chi Kei Wong, Li Wei and Qingpeng Zhang 2021. Derivation of an electronic frailty index for predicting short-term mortality in heart failure: a machine learning approach. ESC Heart Failure. 8 (4), pp. 2837-2845. https://doi.org/10.1002/ehf2.13358
Worldwide survey of COVID-19–associated arrhythmias
Ellie J. Coromilas, Stephanie Kochav, Isaac Goldenthal, Angelo Biviano, Hasan Garan, Seth Goldbarg, Joon-Hyuk Kim, Ilhwan Yeo, Cynthia Tracy, Shant Ayanian, Joseph Akar, Avinainder Singh, Shashank Jain, Leandro Zimerman, Maurício Pimentel, Stefan Osswald, Raphael Twerenbold, Nicolas Schaerli, Lia Crotti, Daniele Fabbri, Gianfranco Parati, Yi Li, Felipe Atienza, Eduardo Zatarain, Gary Tse, Keith Sai Kit Leung, Milton E. Guevara-Valdivia, Carlos A. Rivera-Santiago, Kyoko Soejima, Paolo De Filippo, Paola Ferrari, Giovanni Malanchini, Prapa Kanagaratnam, Saud Khawaja, Ghada W. Mikhail, Mauricio Scanavacca, Ludhmila Abrahão Hajjar, Brenno Rizerio, Luciana Sacilotto, Reza Mollazadeh, Masoud Eslami, Vahideh Laleh far, Anna Vittoria Mattioli, Giuseppe Boriani, Federico Migliore, Alberto Cipriani, Filippo Donato, Paolo Compagnucci, Michela Casella, Antonio Dello Russo, James Coromilas, Andrew Aboyme, Connor Galen O’Brien, Fatima Rodriguez, Paul J. Wang, Aditi Naniwadekar, Melissa Moey, Chia Siang Kow, Wee Kooi Cheah, Angelo Auricchio, Giulio Conte, Jongmin Hwang, Seongwook Han, Pietro Enea Lazzerini, Federico Franchi, Amato Santoro, Pier Leopoldo Capecchi, Jose A. Joglar, Anna G. Rosenblatt, Marco Zardini, Serena Bricoli, Rosario Bonura, Julio Echarte-Morales, Tomás Benito-González, Carlos Minguito-Carazo, Felipe Fernández-Vázquez and Elaine Y. Wan 2021. Worldwide survey of COVID-19–associated arrhythmias. Circulation: Arrhythmia and Electrophysiology. https://doi.org/10.1161/CIRCEP.120.009458
Development of a multivariable prediction model for severe COVID-19 disease: a population-based study from Hong Kong
Jiandong Zhou, Sharen Lee, Xiansong Wang, Yi Li, William Ka Kei Wu, Tong Liu, Zhidong Cao, Daniel Dajun Zeng, Keith Sai Kit Leung, Abraham Ka Chung Wai, Ian Chi Kei Wong, Bernard Man Yung Cheung, Qingpeng Zhang and Gary Tse 2021. Development of a multivariable prediction model for severe COVID-19 disease: a population-based study from Hong Kong. NPJ Digital Medicine. https://doi.org/10.1038/s41746-021-00433-4
Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning
Sharen Lee, Jiandong Zhou, Wing Tak Wong, Tong Liu, William K. K. Wu, Ian Chi Kei Wong, Qingpeng Zhang and Gary Tse 2021. Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning. BMC Endocrine Disorders. 21 (94). https://doi.org/10.1186/s12902-021-00751-4
Renal protective effects and mechanisms of the angiotensin receptor-neprilysin inhibitor LCZ696 in mice with cardiorenal syndrome
Ying Li, Li Kang, Kai Rong, Yue Zhang, Ya Suo, Meng Yua, Qiankun Bao, Shuai Shao, Gary Tse, Rong Li, Tong Liu and Guangping Li 2021. Renal protective effects and mechanisms of the angiotensin receptor-neprilysin inhibitor LCZ696 in mice with cardiorenal syndrome. Life Sciences. 280, p. 119692. https://doi.org//10.1016/j.lfs.2021.119692
Development of a predictive risk model for all-cause mortality in patients with diabetes in Hong Kong
Sharen Lee, Jiandong Zhou, Keith Sai Kit Leung, William Ka Kei Wu, Wing Tak Wong, Tong Liu, Ian Chi Kei Wong, Kamalan Jeevaratnam, Qingpeng Zhang and Gary Tse 2021. Development of a predictive risk model for all-cause mortality in patients with diabetes in Hong Kong. BMJ Open Diabetes Research and Care. 2021 (9), p. e001950. https://doi.org/10.1136/bmjdrc-2020-001950
Relationship between angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and COVID-19 incidence or severe disease
Tse, Gary, Zhou, Jiandong, Lee, Sharen, Wong, Wing Tak, Li, Xintao, Liu, Tonga, Cao, Zhidong, Zeng, Daniel Dajun, Wai, Abraham K.C., Wong, Ian Chi Keih, Cheung, Bernard Man Yungi and Zhang, Qingpengb 2021. Relationship between angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and COVID-19 incidence or severe disease. Journal of Hypertension. 39 (8), pp. 1717-1724. https://doi.org/10.1097/HJH.0000000000002866
Paediatric/young versus adult patients with long QT syndrome
Sharen Lee, Jiandong Zhou, Kamalan Jeevaratnam, Wing Tak Wong, Ian Chi Kei Wong, Chloe Mak, Ngai Shing Mok, Tong Liu, Qingpeng Zhang and Gary Tse 2021. Paediatric/young versus adult patients with long QT syndrome. Open Heart. 2021 (8), p. e001671. https://doi.org/10.1136/openhrt-2021-001671
A novel cardiovascular magnetic resonance risk score for predicting mortality following surgical aortic valve replacement
Vassilios S. Vassiliou, Menelaos Pavlou, Tamir Malley, Brian P. Halliday, Vasiliki Tsampasian, Claire E. Raphael, Gary Tse, Miguel Silva Vieira, Dominique Auger, Russell Everett, Calvin Chin, Francisco Alpendurada, John Pepper, Dudley J. Pennell, David E. Newby, Andrew Jabbour, Marc R. Dweck and Sanjay K. Prasad 2021. A novel cardiovascular magnetic resonance risk score for predicting mortality following surgical aortic valve replacement. Scientific Reports. https://doi.org/10.1038/s41598-021-99788-7
Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis
Nan Zhang, Yueying Wang, Gary Tse, Panagiotis Korantzopoulos, Konstantinos P Letsas, Qingpeng Zhang, Guangping Li, Gregory Y H Lip and Tong Liu 2021. Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis. European Journal of Preventive Cardiology. 28 (17), pp. 1961-1973. https://doi.org/10.1093/eurjpc/zwab173
Systematic review of renal denervation for the management of cardiac arrhythmias
Nakulan Nantha Kumar, Kuda Nyatsuro, Shiraz Ahmad, Ibrahim T. Fazmin, Khalil Saadeh, Tse, G. and Kamalan Jeevaratnam 2021. Systematic review of renal denervation for the management of cardiac arrhythmias. Clincial Research in Cardiology. (111), pp. 971-993.
Metformin accelerates zebrafish heart regeneration by inducing autophagy.
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Distinct features of probands with early repolarization and Brugada Syndromes carrying SCN5A pathogenic variants
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Atrial cardiomyopathy: An emerging cause of the embolic stroke of undetermined source
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Ventricular tachyarrhythmia risk in paediatric/young vs. adult Brugada Syndrome patients: A territory-wide study
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The association between blood pressure variability and hip or vertebral fracture risk: A population-based study
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Ageing and the autonomic nervous system
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