Insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer

Journal article


Zahra Pezeshkian, Stefania Nobili, Noshad Peyravian, Bahador Shojaee, Haniye Nazari, Hiva Soleimani, Hamid Asadzadeh-Aghdaei, Maziar Ashrafian Bonab, Ehsan Nazemalhosseini-Mojarad and Enrico Mini 2021. Insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer. Cancers. 13 (24), p. 6226. https://doi.org/2072-6694/13/24/6226
AuthorsZahra Pezeshkian, Stefania Nobili, Noshad Peyravian, Bahador Shojaee, Haniye Nazari, Hiva Soleimani, Hamid Asadzadeh-Aghdaei, Maziar Ashrafian Bonab, Ehsan Nazemalhosseini-Mojarad and Enrico Mini
Abstract

Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis

KeywordsMatrix Metalloproteinases (MMPs); Polyp; Colorectal cancer; TIMPs; MMP polymorphisms; MMP targeting
Year2021
JournalCancers
Journal citation13 (24), p. 6226
PublisherMDPI
ISSN2072-6694
Digital Object Identifier (DOI)https://doi.org/2072-6694/13/24/6226
Official URLhttps://www.mdpi.com/2072-6694/13/24/6226
Publication process dates
Accepted07 Dec 2021
Deposited24 May 2023
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Output statusPublished
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https://repository.canterbury.ac.uk/item/94qqz/insights-into-the-role-of-matrix-metalloproteinases-in-precancerous-conditions-and-in-colorectal-cancer

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