Insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer
Journal article
Zahra Pezeshkian, Stefania Nobili, Noshad Peyravian, Bahador Shojaee, Haniye Nazari, Hiva Soleimani, Hamid Asadzadeh-Aghdaei, Maziar Ashrafian Bonab, Ehsan Nazemalhosseini-Mojarad and Enrico Mini 2021. Insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer. Cancers. 13 (24), p. 6226. https://doi.org/2072-6694/13/24/6226
Authors | Zahra Pezeshkian, Stefania Nobili, Noshad Peyravian, Bahador Shojaee, Haniye Nazari, Hiva Soleimani, Hamid Asadzadeh-Aghdaei, Maziar Ashrafian Bonab, Ehsan Nazemalhosseini-Mojarad and Enrico Mini |
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Abstract | Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis |
Keywords | Matrix Metalloproteinases (MMPs); Polyp; Colorectal cancer; TIMPs; MMP polymorphisms; MMP targeting |
Year | 2021 |
Journal | Cancers |
Journal citation | 13 (24), p. 6226 |
Publisher | MDPI |
ISSN | 2072-6694 |
Digital Object Identifier (DOI) | https://doi.org/2072-6694/13/24/6226 |
Official URL | https://www.mdpi.com/2072-6694/13/24/6226 |
Publication process dates | |
Accepted | 07 Dec 2021 |
Deposited | 24 May 2023 |
Publisher's version | License |
Output status | Published |
https://repository.canterbury.ac.uk/item/94qqz/insights-into-the-role-of-matrix-metalloproteinases-in-precancerous-conditions-and-in-colorectal-cancer
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