Clinical characteristics, risk factors and outcomes of cancer patients with COVID-19: A population-based study

Journal article

Jiandong Zhou, Ishan Lakhani, Oscar Chou, Keith Sai Kit Leung, Teddy Tai Loy Lee, Michelle Vangi Wong, Zhen Li, Abraham Ka Chung Wai, Carlin Chang, Ian Chi Kei Wong, Qingpeng Zhang, Gary Tse and Bernard Man Yung Cheung 2022. Clinical characteristics, risk factors and outcomes of cancer patients with COVID-19: A population-based study. Cancer Medicine. 12 (1), pp. 287-296. https://doi.org/10.1002/cam4.4888
AuthorsJiandong Zhou, Ishan Lakhani, Oscar Chou, Keith Sai Kit Leung, Teddy Tai Loy Lee, Michelle Vangi Wong, Zhen Li, Abraham Ka Chung Wai, Carlin Chang, Ian Chi Kei Wong, Qingpeng Zhang, Gary Tse and Bernard Man Yung Cheung
Abstract

Introduction
Cancer patients may be susceptible to poorer outcomes in COVID-19 infection owing to the immunosuppressant effect of chemotherapy/radiotherapy and cancer growth, along with the potential for nosocomial transmission due to frequent hospital admissions.

Methods
This was a population-based retrospective cohort study of COVID-19 patients who presented to Hong Kong public hospitals between 1 January 2020 and 8 December 2020. The primary outcome was a composite endpoint of requirement for intubation, ICU admission and 30-day mortality.

Results
The following study consisted of 6089 COVID-19 patients (median age 45.9 [27.8.1–62.7] years; 50% male), of which 142 were cancer subjects. COVID-19 cancer patients were older at baseline and tended to present with a higher frequency of comorbidities, including diabetes mellitus, hypertension, chronic obstructive pulmonary disease, ischemic heart disease, ventricular tachycardia/fibrillation and gastrointestinal bleeding (p < 0.05). These subjects also likewise tended to present with higher serum levels of inflammatory markers, including D-dimer, lactate dehydrogenase, high sensitivity troponin-I and C-reactive protein. Multivariate Cox regression showed that any type of cancer presented with an almost four-fold increased risk of the primary outcome (HR: 3.77; 95% CI: 1.63–8.72; p < 0.002) after adjusting for significant demographics, Charlson comorbidity index, number of comorbidities, past comorbidities and medication history. This association remained significant when assessing those with colorectal (HR: 5.07; 95% CI: 1.50–17.17; p < 0.009) and gastrointestinal malignancies (HR: 3.79; 95% CI: 1.12–12.88; p < 0.03), but not with lung, genitourinary, or breast malignancies, relative to their respective cancer-free COVID-19 counterparts.

Conclusions
COVID-19 cancer patients are associated with a significantly higher risk of intubation, ICU admission and/or mortality.

KeywordsCancer; COVID-19; Intensive care unit; Intubation; Mortality
Year2022
JournalCancer Medicine
Journal citation12 (1), pp. 287-296
PublisherWiley
ISSN2045-7634
Digital Object Identifier (DOI)https://doi.org/10.1002/cam4.4888
Official URLhttps://onlinelibrary.wiley.com/doi/10.1002/cam4.4888
Publication dates
Online31 May 2022
PrintJan 2023
Publication process dates
Accepted12 Jan 2022
Deposited24 May 2023
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Association between sodium-glucose cotransporter-2 inhibitors and incident atrial fibrillation/atrial flutter in heart failure patients with reduced ejection fraction: a meta-analysis of randomized controlled trials.
Sfairopoulos, Dimitrios, Liu, Tong, Zhang, Nan, Tse, Gary, Bazoukis, George, Letsas, Konstantinos, Goudis, Christos, Milionis, Haralampos, Vrettos, Apostolos and Korantzopoulos, P. 2022. Association between sodium-glucose cotransporter-2 inhibitors and incident atrial fibrillation/atrial flutter in heart failure patients with reduced ejection fraction: a meta-analysis of randomized controlled trials. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10281-3
Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.
Satti, Danish Iltaf, Lee, Yan Hiu Athena, Leung, Keith Sai Kit, Hui, Jeremy Man Ho, Kot, Thompson Ka Ming, Babar, Arslan, Mahalwar, Gauranga, Wai, Abraham Kc, Liu, Tong, Roever, Leonardo, Tse, Gary and Chan, Jeffrey Shi Kai 2022. Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. Journal of Geriatric Cardiology : JGC. 19 (9), pp. 705-711. https://doi.org/10.11909/j.issn.1671-5411.2022.09.002
Predicting stroke and mortality in mitral regurgitation: A machine learning approach
Zhou, Jiandong, Lee, Sharen, Liu, Yingzhi, Chan, Jeffrey Shi Kai, Li, Guoliang, Wong, Wing Tak, Jeevaratnam, Kamalan, Cheng, Shuk Han, Liu, Tong, Tse, Gary and Zhang, Qingpeng 2022. Predicting stroke and mortality in mitral regurgitation: A machine learning approach. Current Problems in Cardiology. 48 (2), p. 101464. https://doi.org/S0146-2806(22)00361-9
Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial.
Anjos, J., Neto, Mansueto Gomes, de Araújo Tapparelli, Yuri, Tse, Gary, Biondi-Zoccai, Giuseppe, de Souza Lima Bitar, Yasmin, Roever, Leonardo and Duraes, Andre Rodrigues 2022. Efficacy and safety of very early mobilization after thrombolysis in acute ischemic stroke: a randomized clinical trial. Journal of Neurology. https://doi.org/10.1007/s00415-022-11411-5
Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings.
Bazoukis, George, Garcia-Zamora, Sebastian, Çinier, Göksel, Lee, Sharen, Elvin Gul, Enes, Álvarez-García, Jesús, Miana, Gabi, Hayıroğlu, Mert İlker, Tse, Gary, Liu, Tong and Baranchuk, Adrian 2022. Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings. World Journal of Cardiology. 14 (9), pp. 483-495. https://doi.org/10.4330/wjc.v14.i9.483
Association between visit-to-visit lipid variability and incident cancer: a population-based cohort study.
Chan, Jeffrey Shi Kai, Satti, Danish Iltaf, Lee, Yan Hiu Athena, Waleed, Khalid Bin, Tang, Pias, Mahalwar, Gauranga, Minhas, Abdul Mannan Khan, Roever, Leonardo, Biondi-Zoccai, Giuseppe, Leung, Fung Ping, Wong, Wing Tak, Liu, Tong, Zhou, Jiandong and Tse, Gary 2022. Association between visit-to-visit lipid variability and incident cancer: a population-based cohort study. Current Problems in Cardiology. 48 (1). https://doi.org/10.1016/j.cpcardiol.2022.101421
Syncope prediction scores in the Emergency Department
Liu, Tong, Liang, Yan, Li, Xiulian, Tse, Gary, King, Emma, Roever, Leonardo and Li, Guangping 2022. Syncope prediction scores in the Emergency Department. Current Cardiology Reviews. 18 (5). https://doi.org/10.2174/1573403x18666220321104129
Comparing the performance of published risk scores in Brugada syndrome: a multi-center cohort study.
Lee, Sharen, Zhou, Jiandong, Chung, Cheuk To, Lee, Rebecca On Yu, Bazoukis, George, Letsas, Konstantinos P, Wong, Wing Tak, Wong, Ian Chi Kei, Mok, Ngai Shing, Liu, Tong, Zhang, Qingpeng and Tse, Gary 2022. Comparing the performance of published risk scores in Brugada syndrome: a multi-center cohort study. Current Problems in Cardiology. https://doi.org/10.1016/j.cpcardiol.2022.101381
Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes
Zhou, Jiandong, Liu, Xuejin, Chou, Oscar Hou-In, Li, Lifang, Lee, Sharen, Wong, Wing Tak, Zhang, Qingpeng, Chang, Carlin, Liu, Tong, Tse, Gary, Jing, Fengshi and Cheung, Bernard Man Yung 2022. Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes. Rheumatology. https://doi.org/6692704
The role of cardiac magnetic resonance in identifying appropriate candidates for cardiac resynchronization therapy - a systematic review of the literature
Bazoukis, G., Hui, Jeremy Man Ho, Lee, Yan Hiu Athena, Chou, Oscar Hou In, Sfairopoulos, Dimitrios, Vlachos, Konstantinos, Saplaouras, Athanasios, Letsas, Konstantinos P, Efremidis, Michael, Tse, Gary, Vassiliou, Vassilios S and Korantzopoulos, Panagiotis 2022. The role of cardiac magnetic resonance in identifying appropriate candidates for cardiac resynchronization therapy - a systematic review of the literature. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10263-5
Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study
Chan, Jeffrey Shi Kai, Lakhani, Ishan, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Cheung, Yiu Ming, Yeung, Hoi Wa, Tang, Pias, Ng, Kenrick, Dee, Edward Christopher, Liu, Tong, Wong, Wing Tak, Tse, Gary and Leung, Fung Ping 2022. Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study. Current Problems in Cardiology. p. 101380. https://doi.org/10.1016/j.cpcardiol.2022.101380
Atrial cardiomyopathy: from cell to bedside.
Li, Mengmeng, Ning, Yuye, Tse, Gary, Saguner, Ardan M, Wei, Meng, Day, John D, Luo, Guogang and Li, G. 2022. Atrial cardiomyopathy: from cell to bedside. ESC Heart Failure. 9 (6), pp. 3768-3784. https://doi.org/10.1002/ehf2.14089
Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis.
Zheng, Yi, Zhang, Nan, Wang, Yueying, Wang, Feng, Li, Guangping, Tse, Gary and Liu, Tong 2022. Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis. Ageing Research Reviews. 81, p. 101707. https://doi.org/S1568-1637(22)00149-0
Development of an electronic frailty index for predicting mortality and complications analysis in pulmonary hypertension using random survival forest model
Zhou, Jiandong, Chou, Oscar Hou In, Wong, Ka Hei Gabriel, Lee, Sharen, Leung, Keith Sai Kit, Liu, Tong, Cheung, Bernard Man Yung, Wong, Ian Chi Kei, Tse, Gary and Zhang, Qingpeng 2022. Development of an electronic frailty index for predicting mortality and complications analysis in pulmonary hypertension using random survival forest model. Frontiers in Cardiovascular Medicine. 9, p. 735906. https://doi.org/10.3389/fcvm.2022.735906
ICIs-related cardiotoxicity in different types of cancer
Dong, Mei, Yu, Ting, Zhang, Zhenzhen, Zhang, Jing, Wang, Rujian, Tse, Gary, Liu, T. and Zhong, Lin 2022. ICIs-related cardiotoxicity in different types of cancer. Journal of Cardiovascular Development and Disease. 9 (7), p. 203. https://doi.org/10.3390/jcdd9070203
Association of visit-to-visit variability in fasting plasma glucose with digestive cancer risk
Zhang, Nan, Wang, Yueying, Tse, Gary, Li, G., Wu, S. and Liu, T. 2022. Association of visit-to-visit variability in fasting plasma glucose with digestive cancer risk. Oxidative Medicine and Cellular Longevity. 2022, p. 4530894. https://doi.org/10.1155/2022/4530894
Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review.
Bazoukis, G., Tyrovolas, Konstantinos, Letsas, Konstantinos P, Vlachos, Konstantinos, Radford, Danny, Chung, Cheuk To, Liu, Tong, Efremidis, Michael, Tse, Gary and Baranchuk, Adrian 2022. Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10257-3
Risk of new-onset prostate cancer for Metformin versus Sulfonylurea use in Type 2 Diabetes Mellitus: A propensity score-matched study
Lee, Yan Hiu Athena, Zhou, Jiandong, Hui, Jeremy Man Ho, Liu, Xuejin, Lee, Teddy Tai Loy, Hui, Kyle, Chan, Jeffrey Shi Kai, Wai, Abraham Ka Chung, Wong, Wing Tak, Liu, Tong, Ng, Kenrick, Lee, Sharen, Dee, Edward Christopher, Zhang, Qingpeng and Tse, Gary 2022. Risk of new-onset prostate cancer for Metformin versus Sulfonylurea use in Type 2 Diabetes Mellitus: A propensity score-matched study. Journal of the National Comprehensive Cancer Network. 20 (6), pp. 674-682.e15. https://doi.org/10.6004/jnccn.2022.7010
Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics
Zhang, Nan, Wang, Yueying, Chen, Ziliang, Liu, Daiqi, Tse, Gary, Korantzopoulos, Panagiotis, Letsas, Konstantinos P., Goudis, Christos A., Lip, Gregory Y. H., Li, Guangping, Zhang, Zhiwei and Liu, Tong 2022. Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics. Frontiers in Nutrition. 9, p. 842392. https://doi.org/10.3389/fnut.2022.842392
A remote mentorship model for empowering students to undertake electrocardiology research: Effects on gender equity.
Nam, Ronald Hang Kin, Tse, Gary, Liu, Tong, Jeevaratnam, Kamalan and Lee, Sharen 2022. A remote mentorship model for empowering students to undertake electrocardiology research: Effects on gender equity. Journal of Electrocardiology. 72, pp. 128-130. https://doi.org/S0022-0736(22)00058-9
Editorial: Risk stratification strategies for cardiac rhythm abnormalities
Tse, Gary, Zhang, Nan, Song, Wenhua, Letsas, Konstantinos P., Ngarmukos, Tachapong, Jeevaratnam, Kamalan and Liu, Tong 2022. Editorial: Risk stratification strategies for cardiac rhythm abnormalities. Frontiers in Cardiovascular Medicine. 9, p. 887461. https://doi.org/10.3389/fcvm.2022.887461
C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies.
Li, Xintao, Peng, Shi, Wu, Xiaoyu, Guan, Bo, Tse, Gary, Chen, Songwen, Zhou, Genqing, Wei, Yong, Gong, Chao, Lu, Xiaofeng, Xu, Juan, Wu, Shouling and Liu, Shaowen 2022. C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies. Nutrition, metabolism, and cardiovascular diseases : NMCD. https://doi.org/S0939-4753(22)00130-2
Pathogenesis and management of Brugada Syndrome: Recent advances and protocol for umbrella reviews of meta-analyses in major arrhythmic events risk stratification
Aziz, H., Zarzecki, Michał P, Garcia-Zamora, Sebastian, Kim, Min Seo, Bijak, Piotr, Tse, Gary, Won, Hong-Hee and Matusik, P. 2022. Pathogenesis and management of Brugada Syndrome: Recent advances and protocol for umbrella reviews of meta-analyses in major arrhythmic events risk stratification. Journal of Clinical Medicine. 11 (7), p. 1912. https://doi.org/jcm11071912
Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study.
Chou, O., Zhou, Jiandong, Lee, Teddy Tai Loy, Kot, Thompson, Lee, Sharen, Wai, Abraham Ka Chung, Wong, Wing Tak, Zhang, Qingpeng, Cheng, Shuk Han, Liu, Tong, Vassiliou, Vassilios S, Cheung, Bernard Man Yung and Tse, Gary 2022. Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study. Clinical Research in Cardiology : Official Journal of the German Cardiac Society. https://doi.org/10.1007/s00392-022-02007-0
Liver immune-related adverse effects of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: A propensity score matched study with competing risk analyses
Zhou, J, Chau, Y-L A, Yoo, J W, Lee, S, Ng, K, Dee, E C, Liu, T, Wai, A K C, Zhang, Q and Tse, G 2022. Liver immune-related adverse effects of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: A propensity score matched study with competing risk analyses. Clinical Oncology (Royal College of Radiologists (Great Britain)). https://doi.org/10.1016/j.clon.2022.03.006
EPR22-112: Risk of prostate cancer for Metformin versus Sulphonylurea monotherapy in Type 2 Diabetes Mellitus: A propensity score-matched retrospective cohort study
Lee, Yan Hiu Athena, Zhou, Jiandong, Hui, Jeremy Man Ho, Liu, Xuejin, Lee, Teddy Tai Loy, Hui, Kyle, Wai, Abraham Ka Chung, Wong, Wing Tak, Liu, Tong, Ng, Kenrich, Lee, Sharen, Dee, Edward Christopher, Chan, Jeffrey Shi Kai, Zhang, Qingpeng and Tse, Gary 2022. EPR22-112: Risk of prostate cancer for Metformin versus Sulphonylurea monotherapy in Type 2 Diabetes Mellitus: A propensity score-matched retrospective cohort study. Journal of the National Comprehensive Cancer Network. 20 (3.5), pp. EPR22-112. https://doi.org/10.6004/jnccn.2021.7189
Predictive risk models for forecasting arrhythmic outcomes in Brugada syndrome: A focused review
Chung, Cheuk To, Bazoukis, George, Radford, Danny, Coakley-Youngs, Emma, Rajan, Rajesh, Matusik, Paweł T, Liu, Tong, Letsas, Konstantinos P, Lee, Sharen and Tse, Gary 2022. Predictive risk models for forecasting arrhythmic outcomes in Brugada syndrome: A focused review. Journal of Electrocardiology. 72, pp. 28-34. https://doi.org/10.1016/j.jelectrocard.2022.02.009
Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome
Letsas, Konstantinos P, Vlachos, Konstantinos, Efremidis, Michael, Dragasis, Stylianos, Korantzopoulos, Panagiotis, Tse, Gary, Liu, Tong, Bazoukis, George, Niarchou, Panagioula, Prappa, Efstathia, Sacher, Frederic, Hocini, Meleze and Baranchuk, Adrian 2022. Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome. Reviews in Cardiovascular Medicine. 23 (2), p. 44. https://doi.org/S1530-6550(22)00331-3
A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction
Wang, Weiding, Mu, Guanyu, Liu, Changle, Xie, Juan, Zhang, Hao, Zhang, Xiaowei, Che, Jingjin, Tse, Gary, Liu, Tong, Li, Guangping and Fu, Huaying 2022. A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction. Frontiers in Cardiovascular Medicine. 9, p. 822314. https://doi.org/10.3389/fcvm.2022.822314
Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration.
Chen, Francis M, Tse, Joyce Ky, Jin, Leigang, Chook, Chui Yiu Bamboo, Leung, Fung Ping, Tse, Gary, Woo, Connie W, Xu, Aimin, Chawla, Ajay, Tian, Xiao Yu, Chan, Ting-Fung and Wong, Wing Tak 2022. Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration. Theranostics. 12 (3), pp. 1161-1172. https://doi.org/10.7150/thno.67515
Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies
Duraes, Andre R, Bitar, Yasmin S, Neto, Mansueto G, Mesquita, Evandro T, Chan, Jeffrey S, Tse, Gary, Liu, Tong, Boochi, Edimar A, Biondi-Zoccai, Giuseppe and Roever, Leonardo 2022. Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies. Minerva Medica. https://doi.org/10.23736/S0026-4806.22.08029-6
Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study.
Zhou, Jiandong, Zhang, Guoming, Chang, Carlin, Chou, O., Lee, Sharen, Leung, Keith Sai Kit, Wong, Wing Tak, Liu, Tong, Wai, Abraham Ka Chung, Cheng, Shuk Han, Zhang, Qingpeng and Tse, Gary 2022. Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study. Acta Diabetologica. https://doi.org/10.1007/s00592-021-01841-4
The value of IGF-1 and IGFBP-1 in patients with heart failure with reduced, mid-range, and preserved ejection fraction
Guo, Shaohua, Gong, Mengqi, Tse, Gary, Li, Guangping, Chen, Kang-Yin and Liu, Tong 2022. The value of IGF-1 and IGFBP-1 in patients with heart failure with reduced, mid-range, and preserved ejection fraction. Frontiers in Cardiovascular Medicine. 8, p. 772105. https://doi.org/10.3389/fcvm.2021.772105
Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression
He, Jinli, Gong, Mengqi, Wang, Zaojia, Liu, Daiqi, Xie, Bingxin, Luo, C., Li, Guangping, Tse, Gary and Liu, T. 2021. Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression. Clinical and Experimental Pharmacology and Physiology. https://doi.org/10.1111/1440-1681.13541
A novel cardiovascular magnetic resonance risk score for predicting mortality following surgical aortic valve replacement
Vassilios S. Vassiliou, Menelaos Pavlou, Tamir Malley, Brian P. Halliday, Vasiliki Tsampasian, Claire E. Raphael, Gary Tse, Miguel Silva Vieira, Dominique Auger, Russell Everett, Calvin Chin, Francisco Alpendurada, John Pepper, Dudley J. Pennell, David E. Newby, Andrew Jabbour, Marc R. Dweck and Sanjay K. Prasad 2021. A novel cardiovascular magnetic resonance risk score for predicting mortality following surgical aortic valve replacement. Scientific Reports. https://doi.org/10.1038/s41598-021-99788-7
Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis
Nan Zhang, Yueying Wang, Gary Tse, Panagiotis Korantzopoulos, Konstantinos P Letsas, Qingpeng Zhang, Guangping Li, Gregory Y H Lip and Tong Liu 2021. Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis. European Journal of Preventive Cardiology. 28 (17), pp. 1961-1973. https://doi.org/10.1093/eurjpc/zwab173
Systematic review of renal denervation for the management of cardiac arrhythmias
Nakulan Nantha Kumar, Kuda Nyatsuro, Shiraz Ahmad, Ibrahim T. Fazmin, Khalil Saadeh, Tse, G. and Kamalan Jeevaratnam 2021. Systematic review of renal denervation for the management of cardiac arrhythmias. Clincial Research in Cardiology. (111), pp. 971-993.
Hip fractures risks in edoxaban versus warfarin users: A propensity score-matched population-based cohort study with competing risk analyses
Zhou, Jiandong, Lee, Sharen, Liu, Xuejin, Iltaf Satti, Danish, Tai Loy Lee, Teddy, Hou In Chou, Oscar, Chang, Carlin, Roever, Leonardo, Tak Wong, Wing, Ka Chung Wai, Abraham, Liu, Tong, Zhang, Qingpeng and Tse, Gary 2021. Hip fractures risks in edoxaban versus warfarin users: A propensity score-matched population-based cohort study with competing risk analyses. Bone. 156, p. 116303. https://doi.org/S8756-3282(21)00469-5
Fragmented QRS is independently predictive of long-term adverse clinical outcomes in Asian patients hospitalized for heart failure: A retrospective cohort study
Chan, Jeffrey Shi Kai, Zhou, Jiandong, Lee, Sharen, Li, Andrew, Tan, Martin, Leung, Keith Sai Kit, Jeevaratnam, Kamalan, Liu, Tong, Roever, Leonardo, Liu, Ying, Tse, Gary and Zhang, Qingpeng 2021. Fragmented QRS is independently predictive of long-term adverse clinical outcomes in Asian patients hospitalized for heart failure: A retrospective cohort study. Frontiers in Cardiovascular Medicine. 8, p. 738417. https://doi.org/10.3389/fcvm.2021.738417
Effect of angiotensin receptor neprilysin inhibitors on left atrial remodeling and prognosis in heart failure
Sun, Yuxi, Song, Shuang, Zhang, Yanli, Mo, Wenqiong, Zhang, Xinxin, Wang, Ning, Xia, Yunlong, Tse, Gary and Liu, Ying 2021. Effect of angiotensin receptor neprilysin inhibitors on left atrial remodeling and prognosis in heart failure. ESC Heart Failure. 9 (1), pp. 667-675. https://doi.org/10.1002/ehf2.13691
Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia
Zhou, Jiandong, Lee, Sharen, Wong, Wing Tak, Waleed, Khalid Bin, Leung, K., Lee, Teddy Tai Loy, Wai, Abraham Ka Chung, Liu, Tong, Chang, Carlin, Cheung, Bernard Man Yung, Zhang, Q. and Tse, G. 2021. Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia. Journal of the American Medical Informatics Association : JAMIA. 29 (2), pp. 335-347. https://doi.org/10.1093/jamia/ocab173
Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors vs. Dipeptidyl Peptidase-4 (DPP4) inhibitors for new-onset dementia: A propensity score-matched population-based study with competing risk analysis
Mui, Jonathan V, Zhou, Jiandong, Lee, Sharen, Leung, Keith Sai Kit, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Tsang, Shek Long, Wai, Abraham Ka Chung, Liu, Tong, Wong, Wing Tak, Chang, Carlin, Tse, Gary and Zhang, Qingpeng 2021. Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors vs. Dipeptidyl Peptidase-4 (DPP4) inhibitors for new-onset dementia: A propensity score-matched population-based study with competing risk analysis. Frontiers in Cardiovascular Medicine. 8, p. 747620. https://doi.org/10.3389/fcvm.2021.747620
Distinct features of probands with early repolarization and Brugada Syndromes carrying SCN5A pathogenic variants
Zhang, Zhong-He, Barajas-Martínez, Hector, Xia, Hao, Li, Bian, Capra, John A, Clatot, Jerome, Chen, Gan-Xiao, Chen, Xiu, Yang, Bo, Jiang, Hong, Tse, Gary, Aizawa, Yoshiyasu, Gollob, Michael H, Scheinman, Melvin, Antzelevitch, Charles and Hu, Dan 2021. Distinct features of probands with early repolarization and Brugada Syndromes carrying SCN5A pathogenic variants. Journal of the American College of Cardiology. 78 (16), pp. 1603-1617. https://doi.org/S0735-1097(21)06008-3
Characteristics and outcomes of heart failure with recovered left ventricular ejection fraction
Zhang, Xinxin, Sun, Yuxi, Zhang, Yanli, Chen, Feifei, Dai, Mengyuan, Si, Jinping, Yang, Jing, Li, Xiao, Li, Jiaxin, Xia, Yunlong, Tse, G. and Liu, Ying 2021. Characteristics and outcomes of heart failure with recovered left ventricular ejection fraction. ESC Heart Failure. 8 (6), pp. 5383-5391. https://doi.org/10.1002/ehf2.13630
Atrial cardiomyopathy: An emerging cause of the embolic stroke of undetermined source
Ning, Yuye, Tse, G., Luo, Guogang and Li, Guoliang 2021. Atrial cardiomyopathy: An emerging cause of the embolic stroke of undetermined source. Frontiers in Cardiovascular Medicine. 8, p. 674612. https://doi.org/10.3389/fcvm.2021.674612
Heart failure with midrange ejection fraction: Prior left ventricular ejection fraction and prognosis
Zhang, Xinxin, Sun, Yuxi, Zhang, Yanli, Chen, Feifei, Zhang, Shuyuan, He, Hongyan, Song, Shuang, Tse, Gary and Liu, Ying 2021. Heart failure with midrange ejection fraction: Prior left ventricular ejection fraction and prognosis. Frontiers in Cardiovascular Medicine. 8, p. 697221. https://doi.org/10.3389/fcvm.2021.697221
Ventricular tachyarrhythmia risk in paediatric/young vs. adult Brugada Syndrome patients: A territory-wide study
Lee, Sharen, Wong, Wing Tak, Wong, Ian Chi Kei, Mak, Chloe, Mok, Ngai Shing, Liu, Tong and Tse, Gary 2021. Ventricular tachyarrhythmia risk in paediatric/young vs. adult Brugada Syndrome patients: A territory-wide study. Frontiers in Cardiovascular Medicine. 8, p. 671666. https://doi.org/10.3389/fcvm.2021.671666
The association between blood pressure variability and hip or vertebral fracture risk: A population-based study
Zhou, Jiandong, Li, Helen, Chang, Carlin, Wu, William K.K., Wang, Xiansong, Liu, Tong, Cheung, Bernard Man Yung, Zhang, Qingpeng, Lee, Sharen and Tse, Gary 2021. The association between blood pressure variability and hip or vertebral fracture risk: A population-based study. Bone. 150, p. 1160115. https://doi.org/10.1016/j.bone.2021.116015
Ageing and the autonomic nervous system
Takla, Michael, Saadeh, Khalil, Tse, Gary, Huang, Christopher L-H and Jeevaratnam, Kamalan 2003. Ageing and the autonomic nervous system. in: Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science Springer. pp. 201-252