Long-term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy
Tse, G. 2022. Long-term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy. European Journal of Clinical Investigation.
Androgen deprivation therapy (ADT), which pharmacologically or surgically suppresses androgen activity, is a key treatment for prostate cancer (PCa).1 However, it is associated with increased cardiovascular risks, including elevated risks of cardiovascular mortality, myocardial infarction and stroke.2, 3 Nonetheless, prior studies have focussed on the first occurrence of adverse cardiovascular events,2, 4, 5 and the burden of cardiovascular hospitalizations in patients with PCa receiving ADT has remained unexplored. Similarly, the long-term burden of cardiovascular mortality amongst ADT users has been underexplored.6, 7 Given the adverse cardiovascular effects of ADT, it is important to better understand the long-term burden of cardiovascular mortality and hospitalizations in these patients. Henceforth, this study aimed to describe the long-term burden of cardiovascular mortality and hospitalizations in patients with PCa receiving ADT.
|Keywords||Androgen deprivation therapy; Cardio-oncology; Epidemiology; Prostate cancer|
|Journal||European Journal of Clinical Investigation|
|Online||05 Dec 2022|
|Publication process dates|
|Accepted||03 Dec 2022|
|Deposited||15 May 2023|
Eur J Clin Investigation - 2022 - Chan - Long‐term cardiovascular burden in prostate cancer patients receiving androgen.pdf
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