Association between sick sinus syndrome and atrial fibrillation: A systematic review and meta-analysis.
Journal article
Liu, Ying, Zheng, Yi, Tse, Gary, Bazoukis, George, Letsas, Konstantinos, Goudis, Christos, Korantzopoulos, Panagiotis, Li, Guangping and Liu, Tong 2023. Association between sick sinus syndrome and atrial fibrillation: A systematic review and meta-analysis. International Journal of Cardiology. 381, pp. 20-36. https://doi.org/10.1016/j.ijcard.2023.03.066
Authors | Liu, Ying, Zheng, Yi, Tse, Gary, Bazoukis, George, Letsas, Konstantinos, Goudis, Christos, Korantzopoulos, Panagiotis, Li, Guangping and Liu, Tong |
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Abstract | Sick sinus syndrome (SSS) and atrial fibrillation (AF) frequently coexist and show a bidirectional relationship. This systematic review and meta-analysis aimed to decipher the precise relationship between SSS and AF, further exploring and comparing different therapy strategies on the occurrence or progression of AF in patients with SSS. A systematic literature search was conducted until November 2022. A total of 35 articles with 37,550 patients were included. Patients with SSS were associated with new-onset AF compared to those without SSS. Catheter ablation was associated with a lower risk of AF recurrence, AF progression, all-cause mortality, stroke and hospitalization of heart failure compared to pacemaker therapy. Regarding the different pacing strategies for SSS, VVI/VVIR has higher risk of new-onset AF than DDD/DDDR. No significant difference was found between AAI/AAIR and DDD/DDDR, as well as between DDD/DDDR and minimal ventricular pacing (MVP) for AF recurrence. AAI/AAIR was associated with higher risk of all-cause mortality when compared to DDD/DDDR, but lower risk of cardiac death when compared to DDD/DDDR. Right atrial septum pacing was associated with a similar risk of new-onset AF or AF recurrence compared to right atrial appendage pacing. SSS is associated with a higher risk of AF. For patients with both SSS and AF, catheter ablation should be considered. This meta-analysis re-emphasizes that high percentage of ventricular pacing should be avoided in patients with SSS in order to decrease AF burden and mortality. [Abstract copyright: Copyright © 2023 Elsevier B.V. All rights reserved.] |
Keywords | Pacemaker; Sick sinus syndrome; Catheter ablation; Atrial fibrillation |
Year | 2023 |
Journal | International Journal of Cardiology |
Journal citation | 381, pp. 20-36 |
Publisher | Elsevier |
ISSN | 1874-1754 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.ijcard.2023.03.066 |
https://doi.org/S0167-5273(23)00477-1 | |
Official URL | https://www.internationaljournalofcardiology.com/article/S0167-5273(23)00477-1/fulltext |
Publication dates | |
Online | 01 May 2023 |
15 Jun 2023 | |
Publication process dates | |
Accepted | 31 Mar 2023 |
Deposited | 20 Apr 2023 |
Output status | Published |
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https://repository.canterbury.ac.uk/item/9469x/association-between-sick-sinus-syndrome-and-atrial-fibrillation-a-systematic-review-and-meta-analysis
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