The use of nanoparticles for targeted drug delivery in non-small cell lung cancer.

Journal article

Holder, Jessica E, Ferguson, C., Oliveira, Elisabete, Lodeiro, Carlos, Trim, Carol M, Byrne, Lee J, Bertolo, Emilia and Wilson, Cornelia M 2023. The use of nanoparticles for targeted drug delivery in non-small cell lung cancer. Frontiers in Oncology. 13, p. 1154318. https://doi.org/10.3389/fonc.2023.1154318
AuthorsHolder, Jessica E, Ferguson, C., Oliveira, Elisabete, Lodeiro, Carlos, Trim, Carol M, Byrne, Lee J, Bertolo, Emilia and Wilson, Cornelia M
AbstractLung cancer is a global health problem affecting millions of people each year. Non-small cell lung cancer (NSCLC) is the most common form of lung cancer with various conventional treatment available in the clinic. Application of these treatments alone often results in high rates of cancer reoccurrence and metastasis. In addition, they can cause damage to healthy tissues, resulting in many adverse effects. Nanotechnology has emerged as a modality for the treatment of cancer. When used in combination with nanoparticles, it is possible to improve the pharmacokinetic and pharmacodynamic profiles of pre-existing drugs used in cancer treatment. Nanoparticles have physiochemical properties such as small size which allowing passage through challenging areas of the body, and large surface area allows for higher doses of drugs to be brought to the tumor site. Nanoparticles can be functionalized which involves modifying the surface chemistry of the particles and allows for the conjugation of ligands (small molecules, antibodies, and peptides). Ligands can be chosen for their ability to target components that are specific to or are upregulated in cancer cells, such as targeting receptors on the tumor surface that are highly expressed in the cancer. This ability to precisely target the tumor can improve the efficacy of drugs and decrease toxic side effects. This review will discuss approaches used for targeting drugs to tumors using nanoparticles, provide examples of how this has been applied in the clinic and highlight future prospects for this technology. [Abstract copyright: Copyright © 2023 Holder, Ferguson, Oliveira, Lodeiro, Trim, Byrne, Bertolo and Wilson.]
KeywordsDrug delivery; Therapeutics; Cancer; Lung cancer; Nanoparticles; Oncology
Year2023
JournalFrontiers in Oncology
Journal citation13, p. 1154318
PublisherFrontiers
ISSN2234-943X
Digital Object Identifier (DOI)https://doi.org/10.3389/fonc.2023.1154318
Official URLhttps://www.frontiersin.org/articles/10.3389/fonc.2023.1154318/full
Publication dates
Online09 Mar 2023
Publication process dates
Deposited29 Mar 2023
Accepted22 Feb 2023
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Bertolo-Pardo, E., George, O., Solscheid, C., Fell, J. and Lisgarten, D. 2011. Extraction and purification of the lectin found in the tubers of Eranthis hyemalis (winter aconite). Journal of Integrated OMICS. 1 (2), pp. 268-272. https://doi.org/10.5584/jiomics.v1i2.72
N1-Benzylidene-N2-(2-((2-((2-(benzylideneamino)ethyl)amino)ethyl)amino)ethyl)ethane-1,2-diamine
Fernández-Lodeiro, J., Nuñez, C., Bertolo-Pardo, E., Capelo, J. and Lodeiro, C. 2012. N1-Benzylidene-N2-(2-((2-((2-(benzylideneamino)ethyl)amino)ethyl)amino)ethyl)ethane-1,2-diamine. Molbank. 2012 (4). https://doi.org/10.3390/M779
N1-((1H-Indazol-5-yl)methylene)-N2-(2-((2-((2-(((1H-indazol-6-yl)methylene)amino)ethyl)amino)ethyl)amino)ethyl)ethane-1,2-diamine
Nuñez, C., Fernández-Lodeiro, J., Fernández-Lodeiro, A., Bertolo-Pardo, E., Capelo, J. and Lodeiro, C. 2012. N1-((1H-Indazol-5-yl)methylene)-N2-(2-((2-((2-(((1H-indazol-6-yl)methylene)amino)ethyl)amino)ethyl)amino)ethyl)ethane-1,2-diamine. Molbank. 2012 (3). https://doi.org/10.3390/M770
N1-(Benzo[b]thiophen-3-ylmethylidene)-N2-(2-((2-((2-(benzo[b]thiophen-3-ylmethylidene)amino)ethyl)amino)ethyl)amino)ethyl)ethane-1,2-diamine
Nuñez, C., Fernández-Lodeiro, J., Fernández-Lodeiro, A., Bertolo-Pardo, E., Capelo, J. and Lodeiro, C. 2012. N1-(Benzo[b]thiophen-3-ylmethylidene)-N2-(2-((2-((2-(benzo[b]thiophen-3-ylmethylidene)amino)ethyl)amino)ethyl)amino)ethyl)ethane-1,2-diamine. Molbank. 2012 (3). https://doi.org/10.3390/M768
Using e-learning to support the development of an undergraduate research culture in sciences
Bertolo-Pardo, E. and Carlton, K. 2008. Using e-learning to support the development of an undergraduate research culture in sciences.
Extraction and purification of Eranthis hyemalis (Winter aconite) tuber lectin using thiourea as an antioxidant
Bertolo-Pardo, E., George, O., Lisgarten, D. and Fell, J. 2009. Extraction and purification of Eranthis hyemalis (Winter aconite) tuber lectin using thiourea as an antioxidant.
Using a Virtual Learning Environment (VLE) to support undergraduate research in sciences
Bertolo-Pardo, E. 2009. Using a Virtual Learning Environment (VLE) to support undergraduate research in sciences.
Improving extraction and purification methods of tuber lectin from winter aconite (Eranthis hyemalis)
Ponsonby, D., Solscheid, C., Fell, J., Lisgarten, D. and Bertolo-Pardo, E. 2007. Improving extraction and purification methods of tuber lectin from winter aconite (Eranthis hyemalis).
Using computer aided assessment for summative assessment: Engaging non-science students with chemistry
Bertolo-Pardo, E. and Lambert, G. 2008. Using computer aided assessment for summative assessment: Engaging non-science students with chemistry.
Focused ultrasound as an efficient methodology for the fast release of mercury from organomercurials in human urine
Bertolo-Pardo, E., Capelo, J., Oliveira, E. and Lodeiro, C. 2007. Focused ultrasound as an efficient methodology for the fast release of mercury from organomercurials in human urine.
Sensing metal ions with two new azomethine-thiophene pincer ligands (NSN): fluorescence and MALDI-TOF MS applications
Bertolo-Pardo, E., Santos, H., Pedras, B., Fernandes, L., Capelo, J., Aviles, T. and Lodeiro, C. 2007. Sensing metal ions with two new azomethine-thiophene pincer ligands (NSN): fluorescence and MALDI-TOF MS applications.
Synthesis, characterisation and metal ion sensing effect of two new flexible ligands derived from 2-hydroxy-1-naphthaldehyde
Bertolo-Pardo, E., Fernández-Lodeiro, J., Pedras, B., Capelo, J., Boucher, M. and Lodeiro, C. 2007. Synthesis, characterisation and metal ion sensing effect of two new flexible ligands derived from 2-hydroxy-1-naphthaldehyde.
Implementing computer aided assessment in chemistry: a case study
Bertolo-Pardo, E. and Lambert, G. 2007. Implementing computer aided assessment in chemistry: a case study.
Four novel N3O4 donor macrocycles and their Lanthanide(III) complexes
Bertolo-Pardo, E., Bastida, R., De Blas, A., Fenton, D., Macias, A., Rodriguez, A., Rodriguez-Blas, T. and Villar, Z. 1998. Four novel N3O4 donor macrocycles and their Lanthanide(III) complexes. Zeitschrift für Naturforschung. 53b (12), pp. 1445-1454.
Lanthanide(III) nitrate complexes of two 17 membered N3O2-donor macrocycles
Bertolo-Pardo, E., Bastida, R., De Blas, A., Fenton, D., Lodeiro, C., Macias, A., Rodriguez, A. and Rodriguez-Blas, T. 1999. Lanthanide(III) nitrate complexes of two 17 membered N3O2-donor macrocycles. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 35 (1/2), pp. 191-198. https://doi.org/10.1023/A:1008182512371
Lanthanide(III) perchlorate complexes of two 24 membered N3O4-donor macrocycles
Bertolo-Pardo, E., Bastida, R., Fenton, D., Lodeiro, C., Macias, A. and Rodriguez, A. 2001. Lanthanide(III) perchlorate complexes of two 24 membered N3O4-donor macrocycles. Journal of Alloys and Compounds. 323-4, pp. 155-158. https://doi.org/10.1016/S0925-8388(01)01109-4
Synthesis of four novel pendant armed macrocyclic ligands and their interaction with lanthanide(III) cations
Bertolo-Pardo, E., Lodeiro, C. and Bastida, R. 2006. Synthesis of four novel pendant armed macrocyclic ligands and their interaction with lanthanide(III) cations. Russian Journal of Coordination Chemistry. 32 (12), pp. 895-900. https://doi.org/10.1134/S1070328406120074
Preliminary results on the analysis of volatile and non-volatile pheromones in Chilocorus nigritus by GC/MS
Burman, J., Bertolo-Pardo, E., Capelo, J. and Ponsonby, D. 2010. Preliminary results on the analysis of volatile and non-volatile pheromones in Chilocorus nigritus by GC/MS. Electronic Journal of Environmental, Agricultural and Food Chemistry. 9 (7), pp. 1274-1282.
Power ultrasound in the classroom: efficient methodology for the fast degradation of organic matter in urine
Bertolo-Pardo, E., Capelo, J., Oliveira, E., Santos, H., Fernández-Lodeiro, J. and Lodeiro, C. 2009. Power ultrasound in the classroom: efficient methodology for the fast degradation of organic matter in urine. Electronic Journal of Environmental, Agricultural and Food Chemistry. 8 (11), pp. 1227-1239.
A new family of NxOy pyridine-containing macrocycles: synthesis and characterization of their Y(III), Ln(III), Zn(II), and Cd(II) coordination compounds
Lodeiro, C., Bastida, R., Bertolo-Pardo, E. and Rodriguez, A. 2004. A new family of NxOy pyridine-containing macrocycles: synthesis and characterization of their Y(III), Ln(III), Zn(II), and Cd(II) coordination compounds. Canadian Journal of Chemistry. 82 (3), pp. 437-447. https://doi.org/10.1139/v03-214
Synthesis and spectroscopic characterization of di-nuclear calcium complexes with oxa-aza macrocyclic ligands
Lodeiro, C., Bertolo-Pardo, E., Capelo, J. and Bastida, R. 2004. Synthesis and spectroscopic characterization of di-nuclear calcium complexes with oxa-aza macrocyclic ligands. Zeitschrift für anorganische und allgemeine Chemie. 630 (6), pp. 914-920. https://doi.org/10.1002/zaac.200400039
Manganese(II), cobalt(II), and nickel(II) perchlorate complexes containing N, O Donor macrocyclic ligands
Lodeiro, C., Capelo, J., Bertolo-Pardo, E. and Bastida, R. 2004. Manganese(II), cobalt(II), and nickel(II) perchlorate complexes containing N, O Donor macrocyclic ligands. Zeitschrift für anorganische und allgemeine Chemie. 630 (7), pp. 1110-1115. https://doi.org/10.1002/zaac.200400087
Metal complexes with four macrocyclic ligands derived from 2,6-bis(2-formylphenoxymethyl)pyridine and 1,7-bis(2′-formylphenyl)-1,4,7-trioxaheptane
Lodeiro, C., Bastida, R., Bertolo-Pardo, E., Macias, A. and Rodriguez, A. 2003. Metal complexes with four macrocyclic ligands derived from 2,6-bis(2-formylphenoxymethyl)pyridine and 1,7-bis(2′-formylphenyl)-1,4,7-trioxaheptane. Inorganica Chimica Acta. 343, pp. 133-140. https://doi.org/10.1016/S0020-1693(02)01172-6
Synthesis and characterisation of four novel NxOy-Schiff-base macrocyclic ligands and their metal complexes
Lodeiro, C., Bastida, R., Bertolo-Pardo, E., Macias, A. and Rodriguez, A. 2003. Synthesis and characterisation of four novel NxOy-Schiff-base macrocyclic ligands and their metal complexes. Transition Metal Chemistry. 28 (4), pp. 388-394. https://doi.org/10.1023/A:1023672629805
Lanthanide(III) complexes with pyridine head macrocyclic ligands
Bertolo-Pardo, E., Bastida, R., Fenton, D., Lodeiro, C., Macias, A. and Rodriguez, A. 2003. Lanthanide(III) complexes with pyridine head macrocyclic ligands. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 45 (1-2), pp. 155-160. https://doi.org/10.1023/A:1023021125195
Coordination chemistry of copper(II) with oxaaza macrocyclic ligands: crystal structure of a dinuclear tetramer copper(II) complex
Lodeiro, C., Bastida, R., Bertolo-Pardo, E., Macias, A. and Rodriguez, A. 2003. Coordination chemistry of copper(II) with oxaaza macrocyclic ligands: crystal structure of a dinuclear tetramer copper(II) complex. Polyhedron. 22 (13), pp. 1701-1710. https://doi.org/10.1016/S0277-5387(03)00332-2
Simulating environmental surveys using custom developed software
Bertolo-Pardo, E. and Clay, S. 2006. Simulating environmental surveys using custom developed software. Planet. 17, pp. 42-43.
Research informed teaching: enhancing the teaching-research nexus in science disciplines
Bertolo-Pardo, E. 2009. Research informed teaching: enhancing the teaching-research nexus in science disciplines. in: Lazinica, A. and Calafate, C. (ed.) Technology, Education and Development In-Tech. pp. 367-376
Engaging bioscience students with chemistry using VLEs
Bertolo-Pardo, E. 2008. Engaging bioscience students with chemistry using VLEs. Centre for Bioscience Bulletin. 23, p. 11.
Synthesis, characterization, and fluorescence behaviour of four novel macrocyclic emissive ligands containing a flexible 8-hydroxyquinoline unit
Nuñez, C., Bastida, R., Macias, A., Bertolo-Pardo, E., Fernandes, L., Capelo, J. and Lodeiro, C. 2009. Synthesis, characterization, and fluorescence behaviour of four novel macrocyclic emissive ligands containing a flexible 8-hydroxyquinoline unit. Tetrahedron. 65 (31), pp. 6179-6188. https://doi.org/10.1016/j.tet.2009.05.046
Exploiting anionic and cationic interactions with a new emissive imine-based β-naphthol molecular probe
Fernandes, L., Boucher, M., Fernández-Lodeiro, J., Oliveira, E., Nuñez, C., Santos, H., Capelo, J., Faza, O., Bertolo-Pardo, E. and Lodeiro, C. 2009. Exploiting anionic and cationic interactions with a new emissive imine-based β-naphthol molecular probe. Inorganic Chemistry Communications. 12 (9), pp. 905-912. https://doi.org/10.1016/j.inoche.2009.07.011
Web 2.0: Unlearned lessons from previous virtual learning environments
Bertolo-Pardo, E. 2008. Web 2.0: Unlearned lessons from previous virtual learning environments. Bioscience Education e-Journal. 11. https://doi.org/10.3108/beej.11.7
Metal ion interaction with a novel anthracene pendant-armed fluorescent molecular probe: synthesis, characterization, and fluorescence studies
Oliveira, E., Vicente, M., Valencia, L., Macias, A., Bertolo-Pardo, E., Bastida, R. and Lodeiro, C. 2007. Metal ion interaction with a novel anthracene pendant-armed fluorescent molecular probe: synthesis, characterization, and fluorescence studies. Inorganica Chimica Acta. 360 (8), pp. 2734-2743. https://doi.org/10.1016/j.ica.2007.01.024
Sensing metal ions with two new azomethine–thiophene pincer ligands (NSN): fluorescence and MALDI-TOF-MS applications
Pedras, B., Santos, H., Fernandes, L., Covelo, B., Tamayo, A., Bertolo-Pardo, E., Capelo, J., Aviles, T. and Lodeiro, C. 2007. Sensing metal ions with two new azomethine–thiophene pincer ligands (NSN): fluorescence and MALDI-TOF-MS applications. Inorganic Chemistry Communications. 10 (8), pp. 925-929. https://doi.org/10.1016/j.inoche.2007.05.001
N,N'-{1,3-Phenylenebis[methyleneoxy-2,1-phenylene(Z)methylylidene]}bis[1-(1-naphthyl)methanamine]
George, L., Bertolo-Pardo, E. and Lodeiro, C. 2010. N,N'-{1,3-Phenylenebis[methyleneoxy-2,1-phenylene(Z)methylylidene]}bis[1-(1-naphthyl)methanamine]. Molbank. 2010 (4), p. M702. https://doi.org/10.3390/M702
Neuregulins in the nucleus
McClelland, C. and Gullick, W. 2009. Neuregulins in the nucleus. in: Giordano, A. and Normanno, N. (ed.) Breast Cancer In the Post-Genomic Era Springer. pp. 79-86
Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity
McClelland, C. and Gullick, W. 2007. Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity. British Journal of Cancer. 96 (2), pp. 284-289. https://doi.org/10.1038/sj.bjc.6603544
Oxygen diffusion in SrCe 0.95Yb 0.05O 3-d
Bertolo-Pardo, E., Kilner, J. and Sahibzada, M. 2004. Oxygen diffusion in SrCe 0.95Yb 0.05O 3-d. Journal of Solid State Electrochemistry. 8 (9), pp. 585-591. https://doi.org/10.1007/s10008-003-0487-4
99mTc-SnF2 colloid “LLK”: particle size, morphology, and leukocyte labelling behaviour
McClelland, C., Onuegbulem, E., Carter, N., Leahy, M., O'Doherty, M., Pooley, F., O'Doherty, T., Newsam, R., Ensing, G. and Blower, P. 2003. 99mTc-SnF2 colloid “LLK”: particle size, morphology, and leukocyte labelling behaviour. Nuclear Medicine Communications. 24 (2), pp. 191-202. https://doi.org/10.1097/01.mnm.0000057333.59072.1c
Identification of surrogate markers for determining drug activity using proteomics
McClelland, C. and Gullick, W. 2003. Identification of surrogate markers for determining drug activity using proteomics. Biochemical Society Transactions. 31 (6), pp. 1488-1490. https://doi.org/10.1042/bst0311488