PD-1/PD-L1 blockade accelerates the progression of atherosclerosis in cancer patients
Journal article
Dong, Mei, Yu, Ting, Tse, Gary, Lin, Zerun, Lin, Chen, Zhang, Nan, Wang, Rujian, Liu, Tong and Zhong, Lin 2022. PD-1/PD-L1 blockade accelerates the progression of atherosclerosis in cancer patients. Current Problems in Cardiology. 51, p. 101527. https://doi.org/10.1016/j.cpcardiol.2022.101527
| Authors | Dong, Mei, Yu, Ting, Tse, Gary, Lin, Zerun, Lin, Chen, Zhang, Nan, Wang, Rujian, Liu, Tong and Zhong, Lin |
|---|---|
| Abstract | PD-1(programed death-1)/PD-L1(programed death-1 ligand) blockade represents a major breakthrough of anti-cancer therapies, however, it may come with increased risk of cardiovascular morbidity, such as myocarditis, acute coronary syndrome, arrhythmias, etc. Although the PD-1/PD-L1 blockade-related acute coronary syndrome (ACS) is rare, it can be fatal. Previous studies have implicated a role of the PD-1/PD-L1 axis in the development of atherosclerosis. This review explores a hypothesis that PD-1/PD-L1 blockade accelerates the progression of atherosclerosis and promotes plaque rupture, by synthesizing the evidence of vascular inflammation, as well as plaque progression, destabilization and rupture via T-cell activation and effector function. In order to improve the prognosis of cancer patients and decrease the cardiotoxicity of PD-1/PD-L1 blockade therapy, early recognition of PD-1/PD-L1-blockade-related ACS is important. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.] |
| Keywords | Inflammation; PD-1/PD-L1 blockade; Acute coronary syndrome; Plaque |
| Year | 2022 |
| Journal | Current Problems in Cardiology |
| Journal citation | 51, p. 101527 |
| Publisher | Elsevier |
| ISSN | 1535-6280 |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.cpcardiol.2022.101527 |
| Official URL | https://www.sciencedirect.com/science/article/pii/S1474034622000039 |
| Publication dates | |
| Online | 28 Nov 2022 |
| Publication process dates | |
| Accepted | 25 Nov 2022 |
| Deposited | 15 Dec 2022 |
| Output status | Published |
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https://repository.canterbury.ac.uk/item/935z0/pd-1-pd-l1-blockade-accelerates-the-progression-of-atherosclerosis-in-cancer-patients
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