Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings.
Journal article
Bazoukis, George, Garcia-Zamora, Sebastian, Çinier, Göksel, Lee, Sharen, Elvin Gul, Enes, Álvarez-García, Jesús, Miana, Gabi, Hayıroğlu, Mert İlker, Tse, Gary, Liu, Tong and Baranchuk, Adrian 2022. Association of electrocardiographic markers with myocardial fibrosis as assessed by cardiac magnetic resonance in different clinical settings. World Journal of Cardiology. 14 (9), pp. 483-495. https://doi.org/10.4330/wjc.v14.i9.483
Authors | Bazoukis, George, Garcia-Zamora, Sebastian, Çinier, Göksel, Lee, Sharen, Elvin Gul, Enes, Álvarez-García, Jesús, Miana, Gabi, Hayıroğlu, Mert İlker, Tse, Gary, Liu, Tong and Baranchuk, Adrian |
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Abstract | Cardiac magnetic resonance (CMR) is a unique tool for non-invasive tissue characterization, especially for identifying fibrosis. To present the existing data regarding the association of electrocardiographic (ECG) markers with myocardial fibrosis identified by CMR - late gadolinium enhancement (LGE). A systematic search was performed for identifying the relevant studies in Medline and Cochrane databases through February 2021. In addition, we conducted a relevant search by (RCA) (https://www.referencecitationanalysis.com). A total of 32 studies were included. In hypertrophic cardiomyopathy (HCM), fragmented QRS (fQRS) is related to the presence and extent of myocardial fibrosis. fQRS and abnormal Q waves are associated with LGE in ischemic cardiomyopathy patients, while fQRS has also been related to fibrosis in myocarditis. Selvester score, abnormal Q waves, and notched QRS have also been associated with LGE. Repolarization abnormalities as reflected by increased Tp-Te, negative T-waves, and higher QT dispersion are related to myocardial fibrosis in HCM patients. In patients with Duchenne muscular dystrophy, a significant correlation between fQRS and the amount of myocardial fibrosis as assessed by LGE-CMR was observed. In atrial fibrillation patients, advanced inter-atrial block is defined as P-wave duration ≥ 120 ms, and biphasic morphology in inferior leads is related to left atrial fibrosis. Myocardial fibrosis, a reliable marker of prognosis in a broad spectrum of cardiovascular diseases, can be easily understood with an easily applicable ECG. However, more data is needed on a specific disease basis to study the association of ECG markers and myocardial fibrosis as depicted by CMR. [Abstract copyright: ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.] |
Keywords | Cardiac magnetic resonance; Electrocardiogram; Myocardial fibrosis; Late gadolinium enhancement |
Year | 2022 |
Journal | World Journal of Cardiology |
Journal citation | 14 (9), pp. 483-495 |
ISSN | 1949-8462 |
Digital Object Identifier (DOI) | https://doi.org/10.4330/wjc.v14.i9.483 |
Official URL | https://www.wjgnet.com/1949-8462/full/v14/i9/483.htm |
Publication dates | |
Online | 26 Sep 2022 |
Publication process dates | |
Accepted | 17 Aug 2022 |
Deposited | 17 Oct 2022 |
Output status | Published |
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https://repository.canterbury.ac.uk/item/92x4v/association-of-electrocardiographic-markers-with-myocardial-fibrosis-as-assessed-by-cardiac-magnetic-resonance-in-different-clinical-settings
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