Association between visit-to-visit lipid variability and incident cancer: a population-based cohort study.
Journal article
Chan, Jeffrey Shi Kai, Satti, Danish Iltaf, Lee, Yan Hiu Athena, Waleed, Khalid Bin, Tang, Pias, Mahalwar, Gauranga, Minhas, Abdul Mannan Khan, Roever, Leonardo, Biondi-Zoccai, Giuseppe, Leung, Fung Ping, Wong, Wing Tak, Liu, Tong, Zhou, Jiandong and Tse, Gary 2022. Association between visit-to-visit lipid variability and incident cancer: a population-based cohort study. Current Problems in Cardiology. 48 (1). https://doi.org/10.1016/j.cpcardiol.2022.101421
| Authors | Chan, Jeffrey Shi Kai, Satti, Danish Iltaf, Lee, Yan Hiu Athena, Waleed, Khalid Bin, Tang, Pias, Mahalwar, Gauranga, Minhas, Abdul Mannan Khan, Roever, Leonardo, Biondi-Zoccai, Giuseppe, Leung, Fung Ping, Wong, Wing Tak, Liu, Tong, Zhou, Jiandong and Tse, Gary |
|---|---|
| Abstract | Dyslipidaemia is associated with increased cancer risk. However, the prognostic value of visit-to-visit lipid variability (VVLV) is unexplored in this regard. To investigate the associations between VVLV and the risk of incident cancer, we conducted a retrospective cohort study on adult patients attending a family medicine clinic in Hong Kong during 2000-2003, excluding those with <3 tests for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and total cholesterol (TC) each, those with prior cancer diagnosis, and those with <1 year of follow-up. Visit-to-visit LDL-C, HDL-C, TC, and triglycerides variabilities were measured by the coefficient of variation (CV). Patients were followed up until 31 December 2019 for the primary outcome of incident cancer. Altogether, 69,186 patients were included (26,679 males (38.6%); mean age 60±13 years; mean follow-up 16±3 years); 7958 patients (11.5%) had incident cancer. Higher variability of LDL-C, HDL-C, TC, and TG was associated with higher risk of incident cancer. Patients in the third tercile of the CV of LDL-C (adjusted hazard ratio (aHR) against first tercile 1.06 [1.00, 1.12], p=0.049), HDL-C (aHR 1.37 [1.29, 1.44], p<0.001), TC (aHR 1.10 [1.04, 1.17], p=0.001), and TG (aHR 1.11 [1.06, 1.18], p<0.001) had the highest risks of incident cancer. Among these, only HDL-C variability remained associated with the risk of incident cancer in users of statins/fibrates. To conclude, higher VVLV was associated with significantly higher long-term risks of incident cancer. VVLV may be a clinically useful tool for cancer risk stratification. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.] |
| Keywords | Preventive cardiology; Family medicine; Cancer; Cholesterol; Variability |
| Year | 2022 |
| Journal | Current Problems in Cardiology |
| Journal citation | 48 (1) |
| Publisher | Elsevier |
| ISSN | 1535-6280 |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.cpcardiol.2022.101421 |
| Official URL | https://www.sciencedirect.com/science/article/pii/S0146280622003188 |
| Publication dates | |
| Online | 24 Sep 2022 |
| Publication process dates | |
| Accepted | 21 Sep 2022 |
| Deposited | 13 Oct 2022 |
| Publisher's version | License |
| Output status | Published |
Permalink -
https://repository.canterbury.ac.uk/item/92wy7/association-between-visit-to-visit-lipid-variability-and-incident-cancer-a-population-based-cohort-study
Download files
48
total views16
total downloads1
views this month1
downloads this month