Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study.

Journal article


Chan, Jeffrey Shi Kai, Lakhani, Ishan, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Cheung, Yiu Ming, Yeung, Hoi Wa, Tang, Pias, Ng, Kenrick, Dee, Edward Christopher, Liu, Tong, Wong, Wing Tak, Tse, Gary and Leung, Fung Ping 2022. Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study. Current Problems in Cardiology. p. 101380. https://doi.org/10.1016/j.cpcardiol.2022.101380
AuthorsChan, Jeffrey Shi Kai, Lakhani, Ishan, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Cheung, Yiu Ming, Yeung, Hoi Wa, Tang, Pias, Ng, Kenrick, Dee, Edward Christopher, Liu, Tong, Wong, Wing Tak, Tse, Gary and Leung, Fung Ping
AbstractImmune checkpoint inhibitors (ICI) have known associations with cardiotoxicity. However, a representative quantification of the adverse cardiovascular events and cardiovascular attendances amongst Asian users of ICI has been lacking. This retrospective cohort study identified all ICI users in Hong Kong, China, between 2013-2021. All patients were followed up until the end of 2021 for the primary outcome of major adverse cardiovascular event (MACE; a composite of cardiovascular mortality, myocardial infarction, heart failure, and stroke). Patients with prior diagnosis of any component of MACE were excluded from all MACE analyses. In total, 4324 patients were analysed (2905 (67.2%) males; median age 63.5 years old (interquartile range 55.4-70.7 years old); median follow-up 1.0 year (interquartile range 0.4-2.3 years)), of whom 153 were excluded from MACE analyses due to prior events. MACE occurred in 116 (2.8%) with an incidence rate (IR) of 1.7 [95% confidence interval: 1.4, 2.0] events per 100 patient-years; IR was higher within the first year of follow-up (2.9 [2.3, 3.5] events per 100 patient-years). Cardiovascular hospitalization(s) occurred in 188 (4.4%) with 254 episodes (0.5% of all episodes) and 1555 days of hospitalization (1.3% of all hospitalized days), for whom the IR of cardiovascular hospitalization was 5.6 [4.6, 6.9] episodes per 100 person-years with 52.9 [39.8, 70.3] days' stay per 100 person-years. Amongst Asian users of ICI, MACE was uncommon, and a small proportion of hospitalizations was cardiovascular in nature. Most MACE and cardiovascular hospitalizations occurred during the first year after initiating ICI. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.]
KeywordsCardio-oncology; CTLA4; PD-1; PD-L1; Immunotherapy
Year2022
JournalCurrent Problems in Cardiology
Journal citationp. 101380
PublisherElsevier
ISSN1535-6280
Digital Object Identifier (DOI)https://doi.org/10.1016/j.cpcardiol.2022.101380
Official URLhttps://www.sciencedirect.com/science/article/pii/S0146280622002778?via%3Dihub
Publication dates
Online27 Aug 2022
Publication process dates
Accepted19 Aug 2022
Deposited12 Sep 2022
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Output statusIn press
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