Regenerative medicine : Challenges and opportunities

Book chapter

Plummer, S. and El Miedany, Y. 2022. Regenerative medicine : Challenges and opportunities. in: El Miedany, Y. (ed.) Musculoskeletal Ultrasound-Guided Regenerative Medicine Springer. pp. 539 -548
AuthorsPlummer, S. and El Miedany, Y.
EditorsEl Miedany, Y.
Abstract

Recent advances in cell and gene therapies are offering new, effective treatment options for patients with ultra-rare and life-threatening conditions. Stem cell-based medicine is now established and will undoubtedly advance towards treating a progressively larger spectrum of diseases. Over the past few years, this field has started to come of age. Over the next decade, it is expected to achieve its long-anticipated potential and begin to fundamentally reshape clinical medicine as we know it. However, although regenerative medicine has the potential to improve health and deliver economic benefits, this relatively new field faces challenges. The consequences of not tackling these challenges would be to waste investment, researcher activity and aspirations to cure, as well as to undermine patient protection. On the other hand, developing policies and procedures are expected to support the development of novel therapies that are both safe and effective. This chapter will address some critical scientific issues for evidence-based implementation and regulation of regenerative medicine. It will start by addressing the challenges facing regenerative medicine followed by the available opportunities and how to respond to these challenges. The chapter will conclude with a discussion to answer the question: is there a bright future for regenerative medicine?

KeywordsRegeneration ; Regenerative medicine ; Media
Page range539 -548
Year2022
Book titleMusculoskeletal Ultrasound-Guided Regenerative Medicine
PublisherSpringer
Output statusPublished
Edition1
Publication dates
Online18 Aug 2022
Publication process dates
Deposited24 Aug 2022
Digital Object Identifier (DOI)https://doi.org/10.1007/978-3-030-98256-0_23
Official URLhttps://link.springer.com/chapter/10.1007/978-3-030-98256-0_23
Permalink -

https://repository.canterbury.ac.uk/item/9215x/regenerative-medicine-challenges-and-opportunities

  • 70
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Consensus on the definitions and descriptions of the domains of the OMERACT Core Outcome Set for shared decision making interventions in rheumatology trials
Décary, Simon, de Wit, Maarten, Naye, Florian, Barton, Jennifer L., Fraenkel, Liana, Li, Linda C., Brooks, Peter, Stacey, Dawn, Maxwell, Lara J., Campbell, Willemina, Hofstetter, Cathie, Voshaar, Marieke, Meara, Alexa, Christensen, Robin, Boonen, Annelies, Suarez-Almazor, Maria E., Meade, Tanya, March, Lyn, Jull, Janet Elizabeth, Alten, Rieke, Morgan, Esi M., Hazlewood, Glen, Barber, Claire, Guillemin, Francis, El-Miedany, Yasser, Mittoo, Shikha, Robertson, Tiffany Westrich, Bartlett, Susan J., Singh, Jasvinder A., Mannion, Melissa, Nasef, Samah Ismail, Boel, Anne, Adebajo, Adewale, Arnaud, Laurent, Gill, Tiffany K., Moholt, Ellen, Burt, Jennifer, Jayatilleke, Arundathi, Hmamouchi, Ihsane, Berthelsen, Dorthe B, Blanco, Francisco J., Mather, Kate, Maharaj, Ajesh, Sharma, Saurab, Caso, Francesco, Beaton, Dorcas, Shea, Beverly, Fong, Christopher, Fernandez, Anthony P., Mackie, Sarah, Nikiphorou, Elena, Jones, Allyson, Greer-Smith, Regina, Sloan, Victor S., Akpabio, Akpabio, Strand, Vibeke, Lee, Rebecca R., Umaefulam, Valerie, Monti, Sara, Abaza, Nouran, Schultz, Grayson, Stones, Simon, Gossec, Laure, Nielsen, Sabrina Mai, Cavallo, Sabrina, Srinivasalu, Hemalatha, Constien, Deb, Evans, Vicki, Tugwell, Peter and Toupin-April, K. 2024. Consensus on the definitions and descriptions of the domains of the OMERACT Core Outcome Set for shared decision making interventions in rheumatology trials. Seminars in Arthritis and Rheumatism. 65, p. 152381. https://doi.org/10.1016/j.semarthrit.2024.152381
Core outcome measurement set for shared decision making in rheumatic and musculoskeletal conditions: A scoping review to identify candidate instruments
Naye, Florian, Toupin-April, Karine, de Wit, Maarten, LeBlanc, Annie, Dubois, Olivia, Boonen, Annelies, Barton, Jennifer L., Fraenkel, Liana, Li, Linda C., Stacey, Dawn, March, Lyn, Barber, Claire E.H., Hazlewood, Glen Stewart, Guillemin, Francis, Bartlett, Susan J., Berthelsen, Dorthe B., Mather, Kate, Arnaud, Laurent, Akpabio, Akpabio, Adebajo, Adewale, Schultz, Grayson, Sloan, Victor S., Gill, Tiffany K., Sharma, Saurab, Scholte-Voshaar, Marieke, Caso, Francesco, Nikiphorou, Elena, Nasef, Samah Ismail, Campbell, Willemina, Meara, Alexa, Christensen, Robin, Suarez-Almazor, Maria E., Jull, Janet Elizabeth, Alten, Rieke, Morgan, Esi M., El-Miedany, Yasser, Singh, Jasvinder A., Burt, Jennifer, Jayatilleke, Arundathi, Hmamouchi, Ihsane, Blanco, Francisco J., Fernandez, Anthony P., Mackie, Sarah, Jones, Allyson, Strand, Vibeke, Monti, Sara, Stones, Simon R., Lee, Rebecca R., Nielsen, Sabrina Mai, Evans, Vicki, Srinivasalu, Hemalatha, Gérard, Thomas, Demers, Juliette LeBlanc, Bouchard, Roxanne, Stefan, Théo, Dugas, Michèle, Bergeron, Frédéric, Beaton, Dorcas, Maxwell, Lara J., Tugwell, Peter and Décary, Simon 2023. Core outcome measurement set for shared decision making in rheumatic and musculoskeletal conditions: A scoping review to identify candidate instruments. Seminars in Arthritis and Rheumatism. 65, p. 152344. https://doi.org/10.1016/j.semarthrit.2023.152344
Beyond the symptoms: Personalizing giant cell arteritis care through multidimensional patient reported outcome measure
El Miedany, Y., El Gaafary, M, Toth, M, Palmer, D., Ali, Ayman, Bahlas, S., Mahran, S., Hassan, W., Abu-Zaid, M H, Saber, S. and Elwakil, W. 2023. Beyond the symptoms: Personalizing giant cell arteritis care through multidimensional patient reported outcome measure. Seminars in Arthritis and Rheumatism. 63, p. 152285. https://doi.org/10.1016/j.semarthrit.2023.152285
Prevalence of glucocorticoid-induced osteoporosis among rheumatology patients in Africa: a systematic review and meta-analysis.
Hmamouchi, I., Paruk, Farhanah, Tabra, Samar, Maatallah, Kaouther, Bouziane, Amal, Abouqal, Redouane, El Maidany, Yasser, El Maghraoui, Abdellah and Kalla, Asgar Ali 2023. Prevalence of glucocorticoid-induced osteoporosis among rheumatology patients in Africa: a systematic review and meta-analysis. Archives of Osteoporosis. 18 (1), p. 59. https://doi.org/10.1007/s11657-023-01246-6
Consensus evidence-based clinical practice recommendations for the diagnosis and treat-to-target management of osteoporosis in chronic kidney disease stages G4-G5D and post-transplantation: An initiative of Egyptian Academy of Bone Health
El Miedany, Yasser, Gadallah, Naglaa Ali, Sarhan, Eman, Toth, Mathias, Hasab El Naby, Mona Mansour, Elwy, Mohamed, Ganeb, Sahar, El Gaafary, Maha, Mortada, Mohamed, Nasef, Samah Ismail, Mohannad, Nevine, Mahran, Safaa Ali, Abu-Zaid, Mohammed Hassan, Eissa, Mervat, Hassan, Waleed, Medhat, Basma M, Ghaleb, Rasha, Tabra, Samar Abdelhamed, Saber, Heba Gamal, Ibrahim, Rehab Ali, Saber, Sally and Galal, Salwa 2022. Consensus evidence-based clinical practice recommendations for the diagnosis and treat-to-target management of osteoporosis in chronic kidney disease stages G4-G5D and post-transplantation: An initiative of Egyptian Academy of Bone Health. Kidney Diseases. 8 (5), pp. 392-407. https://doi.org/10.1159/000526492
001 Egyptian consensus-based recommendations for the diagnosis and targeted management of Kawasaki disease. An initiative by the Egyptian College of Pediatric Rheumatology
El Miedany, Y, Lotfy, H, Salah, S, Abu-Zaid, M. H, Mohamed, S. S, Esam Maher, S, El Gaafary, M, Abdulhady, H, Hassan, W. A, Mortada, M, Amer, Y, Osman, N. S, Medhat, B. M, Farag, Y, Eissa, M, Radwan, A, Nasef, S. I, Elkaraly, N. E, El-Shanawany, Amira T, El Mikkawy, D, Mosa, D. M, El Deriny, G, Fouad, N. A and Tabra, S. A 2022. 001 Egyptian consensus-based recommendations for the diagnosis and targeted management of Kawasaki disease. An initiative by the Egyptian College of Pediatric Rheumatology. Rheumatology. 61 (Supplement_2). https://doi.org/10.1093/rheumatology/keac495.001
43 Egyptian evidence-based consensus recommendations for diagnosis and targeted management of childhood-onset systemic lupus erythematosus. An initiative by the Egyptian College of Pediatric Rheumatology
Lotfy, H, El Miedany, Y, Salah, S, Tabra, S. A, Salaby, R. A, Amer, Y, Adel, Y, Osman, N. S, Medhat, B. M, El Gaafary, M, Abdulhady, H, Hassan, W. A, Farag, Y, Eissa, M, Maher, S. Esam, Radwan, A, El-Shanawany, Amira T, El Mikkawy, D, Mosa, D. M, El Deriny, G, Mortada, M, Fouad, N. A, Nasef, S. I, Elkaraly, N. E, Mohamed, S. S and Abu-Zaid, M. H 2022. 43 Egyptian evidence-based consensus recommendations for diagnosis and targeted management of childhood-onset systemic lupus erythematosus. An initiative by the Egyptian College of Pediatric Rheumatology. Rheumatology. 61 (Supplement_2). https://doi.org/10.1093/rheumatology/keac496.039
Rheumatology-led pregnancy clinic: patient-centred approach
El Miedany, Y. and Palmer, D. 2021. Rheumatology-led pregnancy clinic: patient-centred approach. Clinical Rheumatology. 40 (10), pp. 3875-3882. https://doi.org/10.1007/s10067-021-05690-y
Consensus evidence-based recommendations for treat-to-target management of immunoglobulin A vasculitis
Abu-Zaid, M., Salah S., Lotfy H., El Gaafary, M., Abdulhady, H., Tabra, S., Salah, H., Farag, Y., Eissa, M., Maher, S., Radwan, A., El-Shanawany, A., Medhat, B., El Mikkawy, D., Mosa D., El Deriny, G., Mortada M., Osman, N., Fouad, N., Elkaraly, N., Mohamed, S., Hassan, W., Amer, Y., Nasef, S. and El Miedany, Y. 2021. Consensus evidence-based recommendations for treat-to-target management of immunoglobulin A vasculitis. Therapeutic Advances in Musculoskeletal Disease. https://doi.org/10.1177/1759720X211059610
Egyptian consensus on treat-to-target approach for osteoporosis: a clinical practice guideline from the Egyptian Academy of bone health and metabolic bone diseases
El Miedany, Y., Abu-Zaid, M., El Gaafary, M., El Naby, M., Fathi N., Saber H., Hassan, W., Eissa M., Mohannad N., Khaled H., Mortada M., Nasef S., Galal, S., Ghaleb R., Tabra S., Mohamed S., Medhat B., Aly H., Elolemy G., Fouad N., Ganeb S., Adel Y., Ibrahim M., Farouk O. and Gadallah N. 2021. Egyptian consensus on treat-to-target approach for osteoporosis: a clinical practice guideline from the Egyptian Academy of bone health and metabolic bone diseases. Egyptian Rheumatology and Rehabilitation. 48 (5). https://doi.org/10.1186/s43166-020-00056-9
Consensus evidence-based clinical practice guidelines for the diagnosis and treat-to-target management of osteoporosis in Africa: an initiative by the African Society of Bone Health and Metabolic Bone Diseases.
El Miedany, Y., Paruk, F., Kalla, A., Adebajo, A., El Gaafary, M., El Maghraoui, A., Ngandeu, M., Dey, D., Gadallah, Naglaa, Elwy, Mohamed, Moosajee, F., Abu-Zaid, M., Galal, S., Miladi, S., Hassan, W., Fadlelmola, Abubaker and Saber, S. 2021. Consensus evidence-based clinical practice guidelines for the diagnosis and treat-to-target management of osteoporosis in Africa: an initiative by the African Society of Bone Health and Metabolic Bone Diseases. Archives of Osteoporosis. 16 (1), p. 176. https://doi.org/10.1007/s11657-021-01035-z
Is there a potential dual effect of denosumab for treatment of osteoporosis and sarcopenia?
Miedany, Yasser El, Gaafary, Maha El, Toth, Mathias, Hegazi, Mohamed Osama, Aroussy, Nadia El, Hassan, Waleed, Almedany, Samah, Nasr, Annie, Bahlas, Sami, Galal, S. and Egyptian Academy of Bone Health, Metabolic Bone Diseases 2021. Is there a potential dual effect of denosumab for treatment of osteoporosis and sarcopenia? Clinical Rheumatology. https://doi.org/10.1007/s10067-021-05757-w
Endorsement of the OMERACT core domain set for shared decision making interventions in rheumatology trials: Results from a multi-stepped consensus-building approach.
Toupin-April, K., Décary, S., de Wit, M., Meara, A., Barton, J. L., Fraenkel, L., Li, L. C., Brooks, P., Shea, B., Stacey, D., Légaré, F., Lydiatt, A., Hofstetter, C., Proulx, L., Christensen, R., Voshaar, M., Suarez-Almazor, M. E, Boonen, A., Meade, T., March, L., Jull, J. E., Campbell, W., Alten, R., Morgan, E.M., Kelly, A., Kaufman, J., Hill, S., Maxwell, L. J., Guillemin, F., Beaton, D., El-Miedany, Y., Mittoo, S., Westrich Robertson, T., Bartlett, S. J., Singh, J. A., Mannion, M., Nasef, S. I., de Souza, S., Boel, A., Adebajo, A., Arnaud, L., Gill, T. K., Moholt, E., Burt, J., Jayatilleke, A., Hmamouchi, I., Carrott, D., Blanco, F. J., Mather, K., Maharaj, A., Sharma, S., Caso, F., Fong, C., Fernandez, A. P., Mackie, S., Nikiphorou, E., Jones, A., Greer-Smith, R., Sloan, V. S., Akpabio, A., Strand, V., Umaefulam, V., Monti, S., Melburn, C., Abaza, N., Schultz, K., Stones, S., Kiwalkar, S., Srinivasalu, H., Constien, D., King, L. K. and Tugwell, P. 2021. Endorsement of the OMERACT core domain set for shared decision making interventions in rheumatology trials: Results from a multi-stepped consensus-building approach. Seminars in Arthritis and Rheumatism. 51 (3). https://doi.org/10.1016/j.semarthrit.2021.03.017
Rheumatology-led pregnancy clinic: enhancing the care of women with rheumatic diseases during pregnancy
El Miedany, Y. and Palmer, D. 2020. Rheumatology-led pregnancy clinic: enhancing the care of women with rheumatic diseases during pregnancy. Clinical Rheumatology. 39 (12), pp. 3593-3601. https://doi.org/10.1007/s10067-020-05173-6
Widespread lytic lesions—A metastatic or vasculitic process?
Fahd Khan, Srinivasan Srirangan, Yasser El Miedany and Sanjeev Madaan 2016. Widespread lytic lesions—A metastatic or vasculitic process? International Journal of Surgery Case Reports. 18, pp. 18-20. https://doi.org/10.1016/j.ijscr.2015.11.023