Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis.

Journal article


Zheng, Yi, Zhang, Nan, Wang, Yueying, Wang, Feng, Li, Guangping, Tse, Gary and Liu, Tong 2022. Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis. Ageing Research Reviews. 81, p. 101707. https://doi.org/S1568-1637(22)00149-0
AuthorsZheng, Yi, Zhang, Nan, Wang, Yueying, Wang, Feng, Li, Guangping, Tse, Gary and Liu, Tong
AbstractAdvancing age is the most important risk factor of atrial fibrillation (AF). The shortening of telomere length is a biomarker of biologic aging. There is an increasing body of evidence that leucocyte telomere length (LTL) is associated with the risk of AF development. However, the results in these studies were controversial. The current systematic review and meta-analysis was conducted to examine the role of LTL in predicting the incidence of AF. Observational studies reporting the association between LTL and the risk of AF were retrieved through 25th June, 2022 from PubMed and Embase. A total of twelve studies including 18,293 patients were included in the present analysis. Leucocyte telomere shortening was found to be an independent predictor of AF as a continuous variable in both univariate [OR:2.14; 95%CI(1.48,3.10); P < 0.0001] and multivariate analyses [OR:1.41;95%CI(1.11,1.79); P = 0.005], as well as categorical variable in multivariate analysis [OR:1.53; 95%CI(1.04,2.27); P = 0.03]. Furthermore, leucocyte telomere shortening was significantly associated with recurrent AF [OR:4.32;95%CI(2.42,7.69); P < 0.00001] but not new-onset AF [OR:1.14; 95%CI(0.90,1.45); P = 0.29]. Leucocyte telomere shortening was also associated with an increased risk of persistent AF [OR:14.73;95%CI (3.16,68.67); P = 0.0006] and paroxysmal AF [OR:2.74;95%CI(1.45,5.18); P = 0.002]. Besides, LTL was an independent predictor for progression from paroxysmal AF to persistent AF [OR:3.2;95%CI(1.66,6.18); P = 0.0005]. Differences between males [OR:1.99; 95%CI(1.29,3.06); P = 0.002] and females [OR:0.86; 95%CI (0.29,2.56);P = 0.79] were observed. Leucocyte telomere shortening predicts the risk of AF, especially recurrent AF. The predictive value is more prominent in males than in females. Shortening in LTL can predict the progression from paroxysmal to persistent AF. [Abstract copyright: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.]
KeywordsMeta-analysis; Predictor; Atrial fibrillation; Leucocyte telomere shortening; Biological aging
Year2022
JournalAgeing Research Reviews
Journal citation81, p. 101707
ISSN1872-9649
Digital Object Identifier (DOI)https://doi.org/S1568-1637(22)00149-0
https://doi.org/10.1016/j.arr.2022.101707
Official URLhttps://doi.org/10.1016/j.arr.2022.101707
Publication dates
Online03 Aug 2022
Publication process dates
Accepted02 Aug 2022
Deposited22 Aug 2022
Publisher's version
License
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/92128/association-between-leucocyte-telomere-length-and-the-risk-of-atrial-fibrillation-an-updated-systematic-review-and-meta-analysis

Download files


Publisher's version
  • 17
    total views
  • 3
    total downloads
  • 3
    views this month
  • 0
    downloads this month

Export as

Related outputs

The role of cardiac magnetic resonance in identifying appropriate candidates for cardiac resynchronization therapy - a systematic review of the literature
Bazoukis, G., Hui, Jeremy Man Ho, Lee, Yan Hiu Athena, Chou, Oscar Hou In, Sfairopoulos, Dimitrios, Vlachos, Konstantinos, Saplaouras, Athanasios, Letsas, Konstantinos P, Efremidis, Michael, Tse, Gary, Vassiliou, Vassilios S and Korantzopoulos, Panagiotis 2022. The role of cardiac magnetic resonance in identifying appropriate candidates for cardiac resynchronization therapy - a systematic review of the literature. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10263-5
Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study.
Chan, Jeffrey Shi Kai, Lakhani, Ishan, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Lee, Yan Hiu Athena, Cheung, Yiu Ming, Yeung, Hoi Wa, Tang, Pias, Ng, Kenrick, Dee, Edward Christopher, Liu, Tong, Wong, Wing Tak, Tse, Gary and Leung, Fung Ping 2022. Cardiovascular outcomes and hospitalizations in Asian patients receiving immune checkpoint inhibitors: a population-based study. Current Problems in Cardiology. p. 101380. https://doi.org/10.1016/j.cpcardiol.2022.101380
Atrial cardiomyopathy: from cell to bedside.
Li, Mengmeng, Ning, Yuye, Tse, Gary, Saguner, Ardan M, Wei, Meng, Day, John D, Luo, Guogang and Li, G. 2022. Atrial cardiomyopathy: from cell to bedside. ESC Heart Failure. https://doi.org/10.1002/ehf2.14089
Development of an electronic frailty index for predicting mortality and complications Analysis in pulmonary hypertension using random survival forest model
Zhou, Jiandong, Chou, Oscar Hou In, Wong, Ka Hei Gabriel, Lee, Sharen, Leung, Keith Sai Kit, Liu, Tong, Cheung, Bernard Man Yung, Wong, Ian Chi Kei, Tse, Gary and Zhang, Qingpeng 2022. Development of an electronic frailty index for predicting mortality and complications Analysis in pulmonary hypertension using random survival forest model. Frontiers in Cardiovascular Medicine. 9, p. 735906. https://doi.org/10.3389/fcvm.2022.735906
ICIs-related cardiotoxicity in different types of cancer
Dong, Mei, Yu, Ting, Zhang, Zhenzhen, Zhang, Jing, Wang, Rujian, Tse, Gary, Liu, T. and Zhong, Lin 2022. ICIs-related cardiotoxicity in different types of cancer. Journal of Cardiovascular Development and Disease. 9 (7), p. 203. https://doi.org/10.3390/jcdd9070203
Association of visit-to-visit variability in fasting plasma glucose with digestive cancer risk
Zhang, Nan, Wang, Yueying, Tse, Gary, Li, G., Wu, S. and Liu, T. 2022. Association of visit-to-visit variability in fasting plasma glucose with digestive cancer risk. Oxidative Medicine and Cellular Longevity. 2022, p. 4530894. https://doi.org/10.1155/2022/4530894
Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review.
Bazoukis, G., Tyrovolas, Konstantinos, Letsas, Konstantinos P, Vlachos, Konstantinos, Radford, Danny, Chung, Cheuk To, Liu, Tong, Efremidis, Michael, Tse, Gary and Baranchuk, Adrian 2022. Predictors of fatal arrhythmic events in patients with non-compaction cardiomyopathy: a systematic review. Heart Failure Reviews. https://doi.org/10.1007/s10741-022-10257-3
Risk of new-onset prostate cancer for Metformin versus Sulfonylurea use in Type 2 Diabetes Mellitus: A propensity score-matched study
Lee, Yan Hiu Athena, Zhou, Jiandong, Hui, Jeremy Man Ho, Liu, Xuejin, Lee, Teddy Tai Loy, Hui, Kyle, Chan, Jeffrey Shi Kai, Wai, Abraham Ka Chung, Wong, Wing Tak, Liu, Tong, Ng, Kenrick, Lee, Sharen, Dee, Edward Christopher, Zhang, Qingpeng and Tse, Gary 2022. Risk of new-onset prostate cancer for Metformin versus Sulfonylurea use in Type 2 Diabetes Mellitus: A propensity score-matched study. Journal of the National Comprehensive Cancer Network. 20 (6), pp. 674-682.e15. https://doi.org/10.6004/jnccn.2022.7010
Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics
Zhang, Nan, Wang, Yueying, Chen, Ziliang, Liu, Daiqi, Tse, Gary, Korantzopoulos, Panagiotis, Letsas, Konstantinos P., Goudis, Christos A., Lip, Gregory Y. H., Li, Guangping, Zhang, Zhiwei and Liu, Tong 2022. Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics. Frontiers in Nutrition. 9, p. 842392. https://doi.org/10.3389/fnut.2022.842392
A remote mentorship model for empowering students to undertake electrocardiology research: Effects on gender equity.
Nam, Ronald Hang Kin, Tse, Gary, Liu, Tong, Jeevaratnam, Kamalan and Lee, Sharen 2022. A remote mentorship model for empowering students to undertake electrocardiology research: Effects on gender equity. Journal of Electrocardiology. 72, pp. 128-130. https://doi.org/S0022-0736(22)00058-9
Editorial: Risk stratification strategies for cardiac rhythm abnormalities
Tse, Gary, Zhang, Nan, Song, Wenhua, Letsas, Konstantinos P., Ngarmukos, Tachapong, Jeevaratnam, Kamalan and Liu, Tong 2022. Editorial: Risk stratification strategies for cardiac rhythm abnormalities. Frontiers in Cardiovascular Medicine. 9, p. 887461. https://doi.org/10.3389/fcvm.2022.887461
C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies.
Li, Xintao, Peng, Shi, Wu, Xiaoyu, Guan, Bo, Tse, Gary, Chen, Songwen, Zhou, Genqing, Wei, Yong, Gong, Chao, Lu, Xiaofeng, Xu, Juan, Wu, Shouling and Liu, Shaowen 2022. C-reactive protein and atrial fibrillation: Insights from epidemiological and Mendelian randomization studies. Nutrition, metabolism, and cardiovascular diseases : NMCD. https://doi.org/S0939-4753(22)00130-2
Pathogenesis and management of Brugada Syndrome: Recent advances and protocol for umbrella reviews of meta-analyses in major arrhythmic events risk stratification
Aziz, H., Zarzecki, Michał P, Garcia-Zamora, Sebastian, Kim, Min Seo, Bijak, Piotr, Tse, Gary, Won, Hong-Hee and Matusik, P. 2022. Pathogenesis and management of Brugada Syndrome: Recent advances and protocol for umbrella reviews of meta-analyses in major arrhythmic events risk stratification. Journal of Clinical Medicine. 11 (7), p. 1912. https://doi.org/jcm11071912
Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study.
Chou, O., Zhou, Jiandong, Lee, Teddy Tai Loy, Kot, Thompson, Lee, Sharen, Wai, Abraham Ka Chung, Wong, Wing Tak, Zhang, Qingpeng, Cheng, Shuk Han, Liu, Tong, Vassiliou, Vassilios S, Cheung, Bernard Man Yung and Tse, Gary 2022. Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study. Clinical research in cardiology : official journal of the German Cardiac Society. https://doi.org/10.1007/s00392-022-02007-0
Liver immune-related adverse effects of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: A propensity score matched study with competing risk analyses
Zhou, J, Chau, Y-L A, Yoo, J W, Lee, S, Ng, K, Dee, E C, Liu, T, Wai, A K C, Zhang, Q and Tse, G 2022. Liver immune-related adverse effects of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors: A propensity score matched study with competing risk analyses. Clinical Oncology (Royal College of Radiologists (Great Britain)). https://doi.org/10.1016/j.clon.2022.03.006
EPR22-112: Risk of prostate cancer for Metformin versus Sulphonylurea monotherapy in Type 2 Diabetes Mellitus: A propensity score-matched retrospective cohort study
Lee, Yan Hiu Athena, Zhou, Jiandong, Hui, Jeremy Man Ho, Liu, Xuejin, Lee, Teddy Tai Loy, Hui, Kyle, Wai, Abraham Ka Chung, Wong, Wing Tak, Liu, Tong, Ng, Kenrich, Lee, Sharen, Dee, Edward Christopher, Chan, Jeffrey Shi Kai, Zhang, Qingpeng and Tse, Gary 2022. EPR22-112: Risk of prostate cancer for Metformin versus Sulphonylurea monotherapy in Type 2 Diabetes Mellitus: A propensity score-matched retrospective cohort study. Journal of the National Comprehensive Cancer Network. 20 (3.5), pp. EPR22-112. https://doi.org/10.6004/jnccn.2021.7189
Predictive risk models for forecasting arrhythmic outcomes in Brugada syndrome: A focused review
Chung, Cheuk To, Bazoukis, George, Radford, Danny, Coakley-Youngs, Emma, Rajan, Rajesh, Matusik, Paweł T, Liu, Tong, Letsas, Konstantinos P, Lee, Sharen and Tse, Gary 2022. Predictive risk models for forecasting arrhythmic outcomes in Brugada syndrome: A focused review. Journal of Electrocardiology. 72, pp. 28-34. https://doi.org/10.1016/j.jelectrocard.2022.02.009
Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome
Letsas, Konstantinos P, Vlachos, Konstantinos, Efremidis, Michael, Dragasis, Stylianos, Korantzopoulos, Panagiotis, Tse, Gary, Liu, Tong, Bazoukis, George, Niarchou, Panagioula, Prappa, Efstathia, Sacher, Frederic, Hocini, Meleze and Baranchuk, Adrian 2022. Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome. Reviews in Cardiovascular Medicine. 23 (2), p. 44. https://doi.org/S1530-6550(22)00331-3
A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction
Wang, Weiding, Mu, Guanyu, Liu, Changle, Xie, Juan, Zhang, Hao, Zhang, Xiaowei, Che, Jingjin, Tse, Gary, Liu, Tong, Li, Guangping and Fu, Huaying 2022. A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction. Frontiers in Cardiovascular Medicine. 9, p. 822314. https://doi.org/10.3389/fcvm.2022.822314
Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration.
Chen, Francis M, Tse, Joyce Ky, Jin, Leigang, Chook, Chui Yiu Bamboo, Leung, Fung Ping, Tse, Gary, Woo, Connie W, Xu, Aimin, Chawla, Ajay, Tian, Xiao Yu, Chan, Ting-Fung and Wong, Wing Tak 2022. Type 2 innate immunity drives distinct neonatal immune profile conducive for heart regeneration. Theranostics. 12 (3), pp. 1161-1172. https://doi.org/10.7150/thno.67515
Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies
Duraes, Andre R, Bitar, Yasmin S, Neto, Mansueto G, Mesquita, Evandro T, Chan, Jeffrey S, Tse, Gary, Liu, Tong, Boochi, Edimar A, Biondi-Zoccai, Giuseppe and Roever, Leonardo 2022. Effectiveness of sacubitril-valsartan in patients with cancer therapy-related cardiac dysfunction (CTRCD): a systematic review of clinical and preclinical studies. Minerva Medica. https://doi.org/10.23736/S0026-4806.22.08029-6
Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study.
Zhou, Jiandong, Zhang, Guoming, Chang, Carlin, Chou, O., Lee, Sharen, Leung, Keith Sai Kit, Wong, Wing Tak, Liu, Tong, Wai, Abraham Ka Chung, Cheng, Shuk Han, Zhang, Qingpeng and Tse, Gary 2022. Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study. Acta Diabetologica. https://doi.org/10.1007/s00592-021-01841-4
The value of IGF-1 and IGFBP-1 in patients with heart failure with reduced, mid-range, and preserved ejection fraction
Guo, Shaohua, Gong, Mengqi, Tse, Gary, Li, Guangping, Chen, Kang-Yin and Liu, Tong 2022. The value of IGF-1 and IGFBP-1 in patients with heart failure with reduced, mid-range, and preserved ejection fraction. Frontiers in Cardiovascular Medicine. 8, p. 772105. https://doi.org/10.3389/fcvm.2021.772105
Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression
He, Jinli, Gong, Mengqi, Wang, Zaojia, Liu, Daiqi, Xie, Bingxin, Luo, C., Li, Guangping, Tse, Gary and Liu, T. 2021. Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression. Clinical and Experimental Pharmacology and Physiology. https://doi.org/10.1111/1440-1681.13541
Hip fractures risks in edoxaban versus warfarin users: A propensity score-matched population-based cohort study with competing risk analyses
Zhou, Jiandong, Lee, Sharen, Liu, Xuejin, Iltaf Satti, Danish, Tai Loy Lee, Teddy, Hou In Chou, Oscar, Chang, Carlin, Roever, Leonardo, Tak Wong, Wing, Ka Chung Wai, Abraham, Liu, Tong, Zhang, Qingpeng and Tse, Gary 2021. Hip fractures risks in edoxaban versus warfarin users: A propensity score-matched population-based cohort study with competing risk analyses. Bone. 156, p. 116303. https://doi.org/S8756-3282(21)00469-5
Fragmented QRS is independently predictive of long-term adverse clinical outcomes in Asian patients hospitalized for heart failure: A retrospective cohort study
Chan, Jeffrey Shi Kai, Zhou, Jiandong, Lee, Sharen, Li, Andrew, Tan, Martin, Leung, Keith Sai Kit, Jeevaratnam, Kamalan, Liu, Tong, Roever, Leonardo, Liu, Ying, Tse, Gary and Zhang, Qingpeng 2021. Fragmented QRS is independently predictive of long-term adverse clinical outcomes in Asian patients hospitalized for heart failure: A retrospective cohort study. Frontiers in Cardiovascular Medicine. 8, p. 738417. https://doi.org/10.3389/fcvm.2021.738417
Effect of angiotensin receptor neprilysin inhibitors on left atrial remodeling and prognosis in heart failure
Sun, Yuxi, Song, Shuang, Zhang, Yanli, Mo, Wenqiong, Zhang, Xinxin, Wang, Ning, Xia, Yunlong, Tse, Gary and Liu, Ying 2021. Effect of angiotensin receptor neprilysin inhibitors on left atrial remodeling and prognosis in heart failure. ESC Heart Failure. 9 (1), pp. 667-675. https://doi.org/10.1002/ehf2.13691
Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia
Zhou, Jiandong, Lee, Sharen, Wong, Wing Tak, Waleed, Khalid Bin, Leung, K., Lee, Teddy Tai Loy, Wai, Abraham Ka Chung, Liu, Tong, Chang, Carlin, Cheung, Bernard Man Yung, Zhang, Q. and Tse, G. 2021. Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia. Journal of the American Medical Informatics Association : JAMIA. 29 (2), pp. 335-347. https://doi.org/10.1093/jamia/ocab173
Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors vs. Dipeptidyl Peptidase-4 (DPP4) inhibitors for new-onset dementia: A propensity score-matched population-based study with competing risk analysis
Mui, Jonathan V, Zhou, Jiandong, Lee, Sharen, Leung, Keith Sai Kit, Lee, Teddy Tai Loy, Chou, Oscar Hou In, Tsang, Shek Long, Wai, Abraham Ka Chung, Liu, Tong, Wong, Wing Tak, Chang, Carlin, Tse, Gary and Zhang, Qingpeng 2021. Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors vs. Dipeptidyl Peptidase-4 (DPP4) inhibitors for new-onset dementia: A propensity score-matched population-based study with competing risk analysis. Frontiers in Cardiovascular Medicine. 8, p. 747620. https://doi.org/10.3389/fcvm.2021.747620
Distinct features of probands with early repolarization and Brugada Syndromes carrying SCN5A pathogenic variants
Zhang, Zhong-He, Barajas-Martínez, Hector, Xia, Hao, Li, Bian, Capra, John A, Clatot, Jerome, Chen, Gan-Xiao, Chen, Xiu, Yang, Bo, Jiang, Hong, Tse, Gary, Aizawa, Yoshiyasu, Gollob, Michael H, Scheinman, Melvin, Antzelevitch, Charles and Hu, Dan 2021. Distinct features of probands with early repolarization and Brugada Syndromes carrying SCN5A pathogenic variants. Journal of the American College of Cardiology. 78 (16), pp. 1603-1617. https://doi.org/S0735-1097(21)06008-3
Characteristics and outcomes of heart failure with recovered left ventricular ejection fraction
Zhang, Xinxin, Sun, Yuxi, Zhang, Yanli, Chen, Feifei, Dai, Mengyuan, Si, Jinping, Yang, Jing, Li, Xiao, Li, Jiaxin, Xia, Yunlong, Tse, G. and Liu, Ying 2021. Characteristics and outcomes of heart failure with recovered left ventricular ejection fraction. ESC Heart Failure. 8 (6), pp. 5383-5391. https://doi.org/10.1002/ehf2.13630
Atrial cardiomyopathy: An emerging cause of the embolic stroke of undetermined source
Ning, Yuye, Tse, G., Luo, Guogang and Li, Guoliang 2021. Atrial cardiomyopathy: An emerging cause of the embolic stroke of undetermined source. Frontiers in Cardiovascular Medicine. 8, p. 674612. https://doi.org/10.3389/fcvm.2021.674612
Heart failure with midrange ejection fraction: Prior left ventricular ejection fraction and prognosis
Zhang, Xinxin, Sun, Yuxi, Zhang, Yanli, Chen, Feifei, Zhang, Shuyuan, He, Hongyan, Song, Shuang, Tse, Gary and Liu, Ying 2021. Heart failure with midrange ejection fraction: Prior left ventricular ejection fraction and prognosis. Frontiers in Cardiovascular Medicine. 8, p. 697221. https://doi.org/10.3389/fcvm.2021.697221
Ventricular tachyarrhythmia risk in paediatric/young vs. adult Brugada Syndrome patients: A territory-wide study
Lee, Sharen, Wong, Wing Tak, Wong, Ian Chi Kei, Mak, Chloe, Mok, Ngai Shing, Liu, Tong and Tse, Gary 2021. Ventricular tachyarrhythmia risk in paediatric/young vs. adult Brugada Syndrome patients: A territory-wide study. Frontiers in Cardiovascular Medicine. 8, p. 671666. https://doi.org/10.3389/fcvm.2021.671666
The association between blood pressure variability and hip or vertebral fracture risk: A population-based study
Zhou, Jiandong, Li, Helen, Chang, Carlin, Wu, William K.K., Wang, Xiansong, Liu, Tong, Cheung, Bernard Man Yung, Zhang, Qingpeng, Lee, Sharen and Tse, Gary 2021. The association between blood pressure variability and hip or vertebral fracture risk: A population-based study. Bone. 150, p. 1160115. https://doi.org/10.1016/j.bone.2021.116015