Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics
Journal article
Zhang, Nan, Wang, Yueying, Chen, Ziliang, Liu, Daiqi, Tse, Gary, Korantzopoulos, Panagiotis, Letsas, Konstantinos P., Goudis, Christos A., Lip, Gregory Y. H., Li, Guangping, Zhang, Zhiwei and Liu, Tong 2022. Circulating vitamin D concentrations and risk of atrial fibrillation: A Mendelian randomization study using non-deficient range summary statistics. Frontiers in Nutrition. 9, p. 842392. https://doi.org/10.3389/fnut.2022.842392
| Authors | Zhang, Nan, Wang, Yueying, Chen, Ziliang, Liu, Daiqi, Tse, Gary, Korantzopoulos, Panagiotis, Letsas, Konstantinos P., Goudis, Christos A., Lip, Gregory Y. H., Li, Guangping, Zhang, Zhiwei and Liu, Tong |
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| Abstract | Background and Aims: Vitamin D deficiency is a common disorder and has been linked with atrial fibrillation (AF) in several observational studies, although the causal relationships remain unclear. We conducted a Mendelian randomization (MR) analysis to determine the causal association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and AF. Methods and Results: The analyses were performed using summary statistics obtained for single-nucleotide polymorphisms (SNPs) identified from large genome-wide association meta-analyses conducted on serum 25(OH)D (N = 79,366) and AF (N = 1,030,836). Six SNPs related to serum 25(OH)D were used as instrumental variables. The association between 25(OH)D and AF was estimated using both the fixed-effect and random-effects inverse variance weighted (IVW) method. The MR analyses found no evidence to support a causal association between circulating 25(OH)D level and risk of AF using random-effects IVW (odds ratio per unit increase in log 25(OH)D = 1.003, 95% CI, 0.841–1.196; P = 0.976) or fixed-effect IVW method (OR = 1.003, 95% CI, 0.876–1.148; P = 0.968). Sensitivity analyses yielded similar results. No heterogeneity and directional pleiotropy were detected. Conclusion: Using summary statistics, this MR study suggests that genetically predicted circulating vitamin D concentrations, especially for a non-deficient range, were not causally associated with AF in the general population. Future studies using non-linear design and focusing on the vitamin D deficiency population are needed to further evaluate the causal effect of vitamin D concentrations on AF. |
| Keywords | Nutrition; Vitamin D; Mendelian randomization; Single-nucleotide polymorphisms; Causal association; Atrial fibrillation |
| Year | 2022 |
| Journal | Frontiers in Nutrition |
| Journal citation | 9, p. 842392 |
| Publisher | Frontiers |
| ISSN | 2296-861X |
| Digital Object Identifier (DOI) | https://doi.org/10.3389/fnut.2022.842392 |
| Official URL | https://www.frontiersin.org/articles/10.3389/fnut.2022.842392/full |
| Publication dates | |
| Online | 17 Jun 2022 |
| Publication process dates | |
| Accepted | 13 Apr 2022 |
| Deposited | 04 Jul 2022 |
| Publisher's version | License |
| Output status | Published |
| License | http://creativecommons.org/licenses/by/4.0/ |
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https://repository.canterbury.ac.uk/item/9164x/circulating-vitamin-d-concentrations-and-risk-of-atrial-fibrillation-a-mendelian-randomization-study-using-non-deficient-range-summary-statistics
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