Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome

Journal article


Letsas, Konstantinos P, Vlachos, Konstantinos, Efremidis, Michael, Dragasis, Stylianos, Korantzopoulos, Panagiotis, Tse, Gary, Liu, Tong, Bazoukis, George, Niarchou, Panagioula, Prappa, Efstathia, Sacher, Frederic, Hocini, Meleze and Baranchuk, Adrian 2022. Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome. Reviews in Cardiovascular Medicine. 23 (2), p. 44. https://doi.org/S1530-6550(22)00331-3
AuthorsLetsas, Konstantinos P, Vlachos, Konstantinos, Efremidis, Michael, Dragasis, Stylianos, Korantzopoulos, Panagiotis, Tse, Gary, Liu, Tong, Bazoukis, George, Niarchou, Panagioula, Prappa, Efstathia, Sacher, Frederic, Hocini, Meleze and Baranchuk, Adrian
AbstractBrugada syndrome (BrS) is a complex arrhythmogenic disease displaying electrical and micro-structural abnormalities mainly located at the epicardium of the right ventricular outflow tract (RVOT). It is well-known that fibrosis, fatty infiltration, inflammation and reduced gap junction expression have been demonstrated at the epicardial anterior aspect of the RVOT providing the arrhythmogenic substrate for ventricular arrhythmic events in BrS. A number of models have been proposed for the risk stratification of patients with BrS. Endocardial unipolar electroanatomical mapping is an emerging tool that has been reintroduced to identify and quantify epicardial electrical abnormalities. Interestingly, current findings correlate the presence of large-sized endocardial unipolar electroanatomical abnormalities with either ventricular fibrillation inducibility during programmed ventricular stimulation or symptom status. This review aims to present existing data about the role of endocardial unipolar electroanatomical mapping for the identification of RVOT epicardial abnormalities as well as its potential clinical implications in risk stratification of BrS. [Abstract copyright: © 2022 The Author(s). Published by IMR Press.]
KeywordsBrugada syndrome; Electroanatomical mapping; Risk stratification
Year2022
JournalReviews in Cardiovascular Medicine
Journal citation23 (2), p. 44
ISSN1530-6550
Digital Object Identifier (DOI)https://doi.org/S1530-6550(22)00331-3
https://doi.org/10.31083/j.rcm2302044
Official URLhttps://www.imrpress.com/journal/rcm/23/2/10.31083/j.rcm2302044
Publication dates
Online25 Jan 2022
Publication process dates
Accepted08 Jan 2022
Deposited17 Mar 2022
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