A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction
Journal article
Wang, Weiding, Mu, Guanyu, Liu, Changle, Xie, Juan, Zhang, Hao, Zhang, Xiaowei, Che, Jingjin, Tse, Gary, Liu, Tong, Li, Guangping and Fu, Huaying 2022. A novel three-dimensional and tissue Doppler echocardiographic index for diagnosing and prognosticating heart failure with preserved ejection fraction. Frontiers in Cardiovascular Medicine. 9, p. 822314. https://doi.org/10.3389/fcvm.2022.822314
| Authors | Wang, Weiding, Mu, Guanyu, Liu, Changle, Xie, Juan, Zhang, Hao, Zhang, Xiaowei, Che, Jingjin, Tse, Gary, Liu, Tong, Li, Guangping and Fu, Huaying |
|---|---|
| Abstract | Introduction: The diagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging. In this study, a novel echocardiography index based on three-dimensional and tissue Doppler echocardiography for diagnosing and estimating prognosis in HFpEF. Materials and Methods: Patients with symptoms and/or signs of heart failure and normal left ventricular ejection fraction (LVEF ≥50%) who underwent right heart catheterization were screened. Patients were divided based on pulmonary capillary wedge pressure (PCWP) of ≥15 mmHg and PCWP <15 mmHg. A diagnosis of HFpEF was confirmed by PCWP of ≥15 mmHg according to ESC guidelines. A novel index was calculated by the ratio between stroke volume standardized to body surface area (SVI) and tissue Doppler mitral annulus systolic peak velocity S' (SVI/S'). Its diagnostic and prognostic values were determined. Results: A total of 104 patients (mean age 64 ± 12 years) were included. Of these, 63 had PCWP ≥15 mmHg and 41 patients had PCWP <15 mmHg. Compared to the PCWP <15 mmHg group, the ≥15 mmHg group had a significantly lower SVI/S' (P < 0.001). Logistic regression showed that SVI/S' was associated with high PCWP measured invasively. The SVI/S' had an area under the curve of 0.761 for diagnosing classifying between PCWP ≥15 mmHg and <15 mmHg. Kaplan–Meier analysis showed that the lower SVI/S' group showed a poorer prognosis. Conclusions: SVI/S' is a non-invasive index calculated by three-dimensional and tissue Doppler echocardiography. It is a surrogate measure of PCWP and can be used to diagnose and determine prognosis in HFpEF. |
| Keywords | Cardiovascular medicine; Heart failure with preserved ejection fraction; Diagnosis; Prognosis; Novel echocardiography index; Right heart catheterization |
| Year | 2022 |
| Journal | Frontiers in Cardiovascular Medicine |
| Journal citation | 9, p. 822314 |
| Publisher | Frontiers |
| ISSN | 2297-055X |
| Digital Object Identifier (DOI) | https://doi.org/10.3389/fcvm.2022.822314 |
| Official URL | https://www.frontiersin.org/articles/10.3389/fcvm.2022.822314/full |
| Publication dates | |
| Online | 10 Feb 2022 |
| Publication process dates | |
| Accepted | 18 Jan 2022 |
| Deposited | 02 Mar 2022 |
| Publisher's version | License |
| Output status | Published |
| License | http://creativecommons.org/licenses/by/4.0/ |
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https://repository.canterbury.ac.uk/item/90902/a-novel-three-dimensional-and-tissue-doppler-echocardiographic-index-for-diagnosing-and-prognosticating-heart-failure-with-preserved-ejection-fraction
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