Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis
Journal article
Musaab Hamdoob, Maria Satchi, Fay Fawke and Sanjeev Madaan 2021. Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis. JRSM Open. 12 (2). https://doi.org/10.1177/2054270420983105
Authors | Musaab Hamdoob, Maria Satchi, Fay Fawke and Sanjeev Madaan |
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Abstract | Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone antagonist and is given as a loading dose, followed by a monthly maintenance dose. We report a case where a patient was inadvertently given a second loading dose of Degarelix that resulted in acute psychosis in the form of panic attacks, delusions, suicidal thoughts, insomnia and some visual hallucinations, which are not reported as side-effects of Degarelix. |
Keywords | Clinical; Drugs; Oncology; Prostate cancer; Psychiatry; Psychotic disorders (incl schizophrenia) |
Year | 2021 |
Journal | JRSM Open |
Journal citation | 12 (2) |
Publisher | SAGE |
ISSN | 2054-2704 |
Digital Object Identifier (DOI) | https://doi.org/10.1177/2054270420983105 |
Official URL | https://doi.org/10.1177/2054270420983105 |
Publication dates | |
Online | 19 Feb 2021 |
Publication process dates | |
Deposited | 02 Dec 2021 |
Publisher's version | License |
Output status | Published |
https://repository.canterbury.ac.uk/item/8zvxq/mistaken-administration-of-a-repeat-loading-dose-of-degarelix-leading-to-acute-psychosis
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