Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis

Journal article

Musaab Hamdoob, Maria Satchi, Fay Fawke and Sanjeev Madaan 2021. Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis. JRSM Open. 12 (2). https://doi.org/10.1177/2054270420983105
AuthorsMusaab Hamdoob, Maria Satchi, Fay Fawke and Sanjeev Madaan
Abstract

Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone antagonist and is given as a loading dose, followed by a monthly maintenance dose. We report a case where a patient was inadvertently given a second loading dose of Degarelix that resulted in acute psychosis in the form of panic attacks, delusions, suicidal thoughts, insomnia and some visual hallucinations, which are not reported as side-effects of Degarelix.

KeywordsClinical; Drugs; Oncology; Prostate cancer; Psychiatry; Psychotic disorders (incl schizophrenia)
Year2021
JournalJRSM Open
Journal citation12 (2)
PublisherSAGE
ISSN2054-2704
Digital Object Identifier (DOI)https://doi.org/10.1177/2054270420983105
Official URLhttps://doi.org/10.1177/2054270420983105
Publication dates
Online19 Feb 2021
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Deposited02 Dec 2021
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Key clinical issues in renal cancer: a challenge for proteomics
Rosamonde E. Bank, Rachel A. Craven, Patricia Harnden, Sanjeev Madaan, Adrian Joyce and Peter J. Selby 2007. Key clinical issues in renal cancer: a challenge for proteomics. World Journal of Urology. 25, pp. 537-556. https://doi.org/10.1007/s00345-007-0199-y
Unusual squamous cell carcinoma of the scrotum arising from a well healed, innocuous scar of an infertility procedure: a case report
Sanjeev Kotwal, Sanjeev Madaan, Stephen Prescott, Sameer Chilka and Peter Whelan 2007. Unusual squamous cell carcinoma of the scrotum arising from a well healed, innocuous scar of an infertility procedure: a case report. Annals of the Royal College of Surgeons of England. 89 (5), pp. W17-W-19. https://doi.org/10.1308/147870807X188498
Limitations of extracorporeal shock wave lithotripsy
Madaan, S. and Joyce, A. 2007. Limitations of extracorporeal shock wave lithotripsy. Current Opinion in Urology. 17 (2), pp. 109-113. https://doi.org/10.1097/MOU.0b013e32802b70bc
Omental metastasis with malignant ascites: an unusual manifestation of prostatic adenocarcinoma
Sanjeev Madaan, Victor Palit, Patricia Gudgeon and Chandra Shekhar Biyani 2007. Omental metastasis with malignant ascites: an unusual manifestation of prostatic adenocarcinoma. Canadian Urological Association Journal. 1 (3). https://doi.org/10.5489/cuaj.86
Ureteric complications of renal transplantation: the impact of the double J stent and the anterior extravesical ureteroneocystostomy
S. Guleria, R .Chahal, S. Madaan, H. C. Irving, C. G. Newstead, S. G. Pollard and J. P .A. Lodge 2005. Ureteric complications of renal transplantation: the impact of the double J stent and the anterior extravesical ureteroneocystostomy. Transplantation Proceedings. 37 (2), pp. 1054-1056. https://doi.org/10.1016/j.transproceed.2004.12.123
A complex caliceal-cutaneous and caliceal-peritoneal fistula in a renal transplant patient: a case for conservative management
Rohit Chahal, Sanjeev Madaan, Sandeep Guleria, J Peter A Lodge and John A Spencer 2004. A complex caliceal-cutaneous and caliceal-peritoneal fistula in a renal transplant patient: a case for conservative management. International Urology and Nephrology. 36, pp. 245-247. https://doi.org/10.1023/b:urol.0000034654.26422.f7
Transplant renal artery kinking: a rare cause of early graft dysfunction
Mohiuddin Miah, Sanjeev Madaan, David J Kessel, Charles G Newstead and Sandeep Guleria 2004. Transplant renal artery kinking: a rare cause of early graft dysfunction. Nephrology Dialysis Transplantation. 19 (7). https://doi.org/10.1093/ndt/gfh152
5-years outcome of a prospective randomised trial to compare Transurethral Electrovaporization of the Prostate (TUVP) to Standard Transurethral Resection (TURP)
Mohamed Y. Hammadeh, Sanjeev Madaan, John Hines and Timothy Philp 2003. 5-years outcome of a prospective randomised trial to compare Transurethral Electrovaporization of the Prostate (TUVP) to Standard Transurethral Resection (TURP). Urology. 61 (6), pp. 1166-1171. https://doi.org/10.1016/S0090-4295(03)00109-2
Androgen-dependent regulation of human MUC1 mucin expression
Stephen Mitchell, Paul Abel, Sanjeev Madaan, James Jeffs, Khurram Chaudhary, Gordon Stamp and El-Nasir Lalani 2002. Androgen-dependent regulation of human MUC1 mucin expression. Neoplasia. 4 (1), pp. 9-18. https://doi.org/10.1038/sj.neo.7900194
Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer
S.S. El-Sheikh, S. Madaan, A. Alhasso, P. Abel, G. Stamp and E.-N. Lalani 2002. Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. BJU International. 88 (9), pp. 921-927. https://doi.org/10.1046/j.1464-4096.2001.01649.x
Genitourinary neurofibromatosis with prostatic involvement
Madaan, S., Hammadeh, S., Thomas, K., Philp, T. and Singh, M. 2001. Genitourinary neurofibromatosis with prostatic involvement. BJU International. 87 (903).
Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications for prevention and treatment
S. Madaan, P.D. Abel, K.S. Chaudhary, R. Hewitt, M.A. Stott, G.W.H. Stamp and E.-N. Lalani 2001. Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications for prevention and treatment. BJU International. 86 (6), pp. 736-741. https://doi.org/1046/j.1464-410x.2000.00867.x
A 3-year follow-up of a prospective randomized trial comparing transurethral electrovaporization of the prostate with standard transurethral prostatectomy
Hammadeh, M. Y., Madaan, S., Singh, M. and Philp. T. 2001. A 3-year follow-up of a prospective randomized trial comparing transurethral electrovaporization of the prostate with standard transurethral prostatectomy. BJU International. 86 (6), pp. 648-651. https://doi.org/10.1046/j.1464-410x.2000.00879.x
Cyclooxygenase-2 in prostate cancer
Madaan, S., Lalani, E-N. and Abel, P. D. 2000. Cyclooxygenase-2 in prostate cancer. Relias Media.
Urethral metastasis from a rectal adenocarcinoma
Madaan, S., Vohra, A. K., Riaz, A. A., Thomas, K. and Philp, T. 2000. Urethral metastasis from a rectal adenocarcinoma. BJU International. 86 (403).
Restorative proctocolectomy for collagenous colitis
Riaz, A. A,, Stirling, R. W., Madaan, S. and Dawson, P. M. 2000. Restorative proctocolectomy for collagenous colitis. Journal of the Royal Society of Medicine. 93 (5), pp. 261-261. https://doi.org/10.1177/014107680009300513