Soluble suppression of tumorigenicity 2 (sST2) for predicting disease severity or mortality outcomes in cardiovascular diseases: A systematic review and meta-analysis
Journal article
Ip, Christina, Luk, King Sum, Yuen, Vincent Lok Cheung, Chiang, Lorraine, Chan, Ching Ki, Ho, Kevin, Gong, Mengqi, Lee, Teddy Tai Loy, Leung, Keith Sai Kit, Roever, Leonardo, Bazoukis, George, Lampropoulos, Konstantinos, Li, Ka Hou Christien, Tse, Gary, Liu, Tong and International Health Informatics Study (IHIS) Network 2021. Soluble suppression of tumorigenicity 2 (sST2) for predicting disease severity or mortality outcomes in cardiovascular diseases: A systematic review and meta-analysis . International journal of cardiology. Heart & vasculature. 37, p. 100887. https://doi.org/10.1016/j.ijcha.2021.100887
Authors | Ip, Christina, Luk, King Sum, Yuen, Vincent Lok Cheung, Chiang, Lorraine, Chan, Ching Ki, Ho, Kevin, Gong, Mengqi, Lee, Teddy Tai Loy, Leung, Keith Sai Kit, Roever, Leonardo, Bazoukis, George, Lampropoulos, Konstantinos, Li, Ka Hou Christien, Tse, Gary, Liu, Tong and International Health Informatics Study (IHIS) Network |
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Abstract | Soluble suppression of tumorigenicity 2 (sST2) is a member of the interleukin-1 receptor family. It is raised in various cardiovascular diseases, but its value in predicting disease severity or mortality outcomes has been controversial. Therefore, we conducted a systematic review and -analysis to determine whether sST2 levels differed between survivors and non-survivors of patients with cardiovascular diseases, and whether elevated sST2 levels correlated with adverse outcomes. PubMed and Embase were searched until 23rd June 2021 for studies that evaluated the relationship between sST2 levels and cardiovascular disease severity or mortality. A total of 707 entries were retrieved from both databases, of which 14 studies were included in the final -analysis. In acute heart failure, sST2 levels did not differ between survivors and non-survivors (mean difference [MD]: 24.2 ± 13.0 ng/ml; P = 0.06; : 95%). Elevated sST2 levels tend to be associated with increased mortality risk (hazard ratio [HR]: 1.12, 95 %CI: 0.99-1.27, P = 0.07; : 88%). In chronic heart failure sST2 levels were higher in non-survivors than in survivors (MD: 0.19 ± 0.04 ng/ml; P = 0.001; : 0%) and elevated levels were associated with increased mortality risk (HR: 1.64, 95% CI: 1.27-2.12, P < 0.001; : 82%). sST2 levels were significantly higher in severe disease compared to less severe disease (MD: 1.56 ± 0.46 ng/ml; P = 0.001; : 98%). Finally, in stable coronary artery disease, sST2 levels were higher in non-survivors than survivors (MD: 3.0 ± 1.1 ng/ml; P = 0.005; : 80%) and elevated levels were significantly associated with increased mortality risk (HR: 1.32, 95% CI: 1.04-1.68, P < 0.05; : 57%). sST2 significantly predicts disease severity and mortality in cardiovascular disease and is a good predictor of mortality in patients with stable coronary artery disease and chronic heart failure. [Abstract copyright: © 2021 The Authors.] |
Keywords | sST2; Mortality; Soluble suppression of tumorigenicity 2; Heart failure; Coronary artery disease; Severity |
Year | 2021 |
Journal | International journal of cardiology. Heart & vasculature |
Journal citation | 37, p. 100887 |
Publisher | Elsevier |
ISSN | 2352-9067 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.ijcha.2021.100887 |
Official URL | https://www.sciencedirect.com/science/article/pii/S2352906721001755?via%3Dihub |
Publication dates | |
Online | 18 Oct 2021 |
Publication process dates | |
Accepted | 01 Oct 2021 |
Deposited | 16 Jan 2025 |
Publisher's version | License File Access Level Open |
Output status | Published |
Additional information | Publications router. |
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https://repository.canterbury.ac.uk/item/8z947/soluble-suppression-of-tumorigenicity-2-sst2-for-predicting-disease-severity-or-mortality-outcomes-in-cardiovascular-diseases-a-systematic-review-and-meta-analysis
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