Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer
Journal article
S.S. El-Sheikh, S. Madaan, A. Alhasso, P. Abel, G. Stamp and E.-N. Lalani 2002. Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. BJU International. 88 (9), pp. 921-927. https://doi.org/10.1046/j.1464-4096.2001.01649.x
Authors | S.S. El-Sheikh, S. Madaan, A. Alhasso, P. Abel, G. Stamp and E.-N. Lalani |
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Abstract | Objective: To analyse and compare the expression of cyclooxygenase (COX) enzymes in schistosoma-associated bladder cancer, and to determine any association with tumour grade or stage. Materials and methods: Sixty paired samples of tumour and adjacent nonmalignant urothelium were identified. There were 25 squamous and 28 transitional cell carcinomas, and seven adenocarcinomas. Serial sections were obtained and a standard three-layer immunohistochemistry protocol, using COX-1- and COX-2-specific mouse monoclonal antibodies, applied. Results: COX-1 was expressed mostly in nonvascular smooth muscle with weak reactivity in malignant and nonmalignant urothelium. Nonmalignant urothelium expressed COX-2 weakly, notably in areas of dysplasia and squamous metaplasia whereas there was a significant increase in COX-2 (P < 0.001) with moderate to strong granular cytoplasmic expression in all three malignant histological types. The COX-2 reactivity was higher in transitional and adenocarcinomas than in squamous cell carcinoma (P < 0.001). Areas of carcinoma in situ showed COX-2 reactivity comparable with that in invasive areas and more intense than that detected in dysplastic or metaplastic urothelium (P < 0.001). There was a statistically significant positive correlation between COX-2 expression and tumour grade (P = 0.0052). Conclusion: COX-2 is over-expressed in schistosoma-associated bladder cancer, consistent with a potential role for COX-2 inhibitors in the prevention and management of this disease. |
Keywords | Bladder cancer; COX-2 inhibitors |
Year | 2002 |
Journal | BJU International |
Journal citation | 88 (9), pp. 921-927 |
Publisher | Wiley |
ISSN | 1464-4096 |
1464-410X | |
Digital Object Identifier (DOI) | https://doi.org/10.1046/j.1464-4096.2001.01649.x |
Official URL | https://doi.org/10.1046/j.1464-4096.2001.01649.x |
Publication dates | |
Dec 2002 | |
Publication process dates | |
Accepted | 16 Aug 2001 |
Deposited | 25 Oct 2021 |
Output status | Published |
https://repository.canterbury.ac.uk/item/8z546/cyclooxygenase-2-a-possible-target-in-schistosoma-associated-bladder-cancer
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