The role of apoptosis in cryopreserved animal oocytes and embryos

Journal article

Vining, Lucy May, Zak, Louisa J, Harvey, Simon Crawford and Harvey, K. 2021. The role of apoptosis in cryopreserved animal oocytes and embryos. Theriogenology. 173, pp. 93-101. https://doi.org/S0093-691X(21)00242-9

Publication dates
Authors	Vining, Lucy May, Zak, Louisa J, Harvey, Simon Crawford and Harvey, K.
Abstract	Cryopreservation of both gametes and embryos, both for storage and for the preservation of their developmental capacity is a critical aspect of assisted reproductive technology. The survival of reproductive material following cryopreservation protocols is not only vital to clinical applications in the human in vitro fertilisation clinic, but is also important in the in vitro production of livestock embryos. The ability to routinely cryopreserve oocytes and embryos of livestock species has the potential to improve animal welfare, reduce environmental impact, and reduce the associated costs for breeding companies through the reduction of live animal transportation. Unfortunately, frozen oocytes and embryos are regularly documented to contain a higher proportion of apoptotic cells compared to their non-frozen counterparts, with freezing procedures thought to trigger apoptotic pathways of cell death. Comparisons between frozen and non-frozen samples also show changes in the gene expression of apoptotic factors such as Bcl-2 and Bax in response to cryopreservation. Apoptotic inhibition has the potential to improve cryosurvival, and how to achieve this is subject to debate. Here, we review how exposure to low temperatures during cryopreservation may be responsible for the abnormal activation of apoptotic pathways in mammalian oocytes and embryos, and discuss the ways in which they can be influenced to improve cryopreservation protocols, particularly in agriculturally important species. [Abstract copyright: Copyright © 2021 Elsevier Inc. All rights reserved.]
Keywords	Apoptosis; Cryopreservation; Bovine; Cell death; Porcine
Year	2021
Journal	Theriogenology
Journal citation	173, pp. 93-101
Publisher	Elsevier
ISSN	1879-3231
Digital Object Identifier (DOI)	https://doi.org/S0093-691X(21)00242-9
	https://doi.org/10.1016/j.theriogenology.2021.07.017
Online	26 Jul 2021
Publication process dates
Deposited	13 Sep 2021
Accepted	25 Jul 2021
Accepted author manuscript	File Access Level Restricted
Output status	In press
Additional information	Publications router: Date 2021-07-25 of type 'accepted_date' included in notification. Publications router: Date 2021-07-26 of type 'publication_date' with format 'electronic' included in notification Publications router: Date 2021-03-02 of type 'received' included in notification Publications router: Date 2021-07-24 of type 'revised' included in notification Publications router: Date 2021-07-25 of type 'accepted' included in notification

Permalink -

https://repository.canterbury.ac.uk/item/8yq4w/the-role-of-apoptosis-in-cryopreserved-animal-oocytes-and-embryos

93
total views
1
total downloads
1
views this month
0
downloads this month

Export as

Related outputs

Supplementation of porcin in vitro maturation medium with FGF2, LIF, and IGF1 enhances cytoplasmic maturation in prepubertal gilts oocytes and improves embryo quality

Serrano Albal, M., Silvestri, G., Kiazim, Lucas G., Vining, Lucy M., Zak, Louisa J., Walling, Grant A., Haigh, Alexandra M., Harvey, Simon C., Harvey, Katie E. and Griffin, Darren K. 2022. Supplementation of porcin in vitro maturation medium with FGF2, LIF, and IGF1 enhances cytoplasmic maturation in prepubertal gilts oocytes and improves embryo quality. Zygote (Cambridge, England). https://doi.org/10.1017/S0967199422000284

Identification of optimal assisted aspiration conditions of oocytes for use in porcine in vitro maturation: a re-evaluation of the relationship between the cumulus oocyte complex and oocyte quality

Silvestri, S., Rathje, C.C., Harvey, S.C., Gould, R.L., Walling, G.A., Ellis, P.J.I., Harvey, K.E. and Griffin D.K. 2020. Identification of optimal assisted aspiration conditions of oocytes for use in porcine in vitro maturation: a re-evaluation of the relationship between the cumulus oocyte complex and oocyte quality. Veterinary Medicine and Science.

Eukaryotic response to hypothermia in relation to integrated stress responses

Adjirackor, N. A., Harvey, K. E. and Harvey, S. C. 2020. Eukaryotic response to hypothermia in relation to integrated stress responses. Cell Stress & Chaperones.

Cryopreservation produces limited long-term effects on the nematode Caenorhabditis elegans

Stastna, J., Yiapanas, A., Mandawala, D., Fowler, K. and Harvey, S. 2019. Cryopreservation produces limited long-term effects on the nematode Caenorhabditis elegans . Cryobiology . https://doi.org/0.1016/j.cryobiol.2019.11.039

The role of chromosome segregation and nuclear organisation in human subfertility

Fowler, K., Mandawala, A. and Griffin, D. 2019. The role of chromosome segregation and nuclear organisation in human subfertility. Biochemical Society Transactions. 47 (1), pp. 425-432. https://doi.org/10.1042/BST20180231

The production of pig preimplantation embryos in vitro: current progress and future prospects

Fowler, K., Mandawala, A., Griffin, D., Walling, G. and Harvey, S. 2018. The production of pig preimplantation embryos in vitro: current progress and future prospects. Reproductive Biology. 18 (3), pp. 203-211. https://doi.org/10.1016/j.repbio.2018.07.001

Canine recommended breed weight ranges are not a good predictor of an ideal body condition score

Smith, E., Davis, K., Sulsh, L., Harvey, S., Fowler, K., Canterbury Christ Church University and Portland Road Veterinary Surgery 2018. Canine recommended breed weight ranges are not a good predictor of an ideal body condition score. Journal Of Animal Physiology And Nutrition. 102 (4), pp. 1088-1090. https://doi.org/10.1111/jpn.12919

Time-lapse embryo imaging and morphokinetic profiling: towards a general characterisation of embryogenesis

Mandawala, A., Harvey, S., Roy, T. and Fowler, K. 2016. Time-lapse embryo imaging and morphokinetic profiling: towards a general characterisation of embryogenesis. Animal Reproduction Science. 174, pp. 2-10. https://doi.org/10.1016/j.anireprosci.2016.09.015

Cryopreservation of animal oocytes and embryos: current progress and future prospects

Mandawala, A., Harvey, S., Roy, T. and Fowler, K. 2016. Cryopreservation of animal oocytes and embryos: current progress and future prospects. Theriogenology. 86 (7), pp. 1637-1644. https://doi.org/10.1016/j.theriogenology.2016.07.018

Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set

Damas, J., O'Connor, R., Farré, M., Lenis, V., Martell, H., Mandawala, A., Fowler, K., Joseph, S., Swain, M., Griffin, D. and Larkin, D. 2016. Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set. Genome Research.

Multicolour detection of every chromosome as a means of detecting mosaicism and nuclear organisation in human embryonic nuclei

Turner, K., Fowler, K., Fonseka, G., Griffin, D. and Ioannou, D. 2016. Multicolour detection of every chromosome as a means of detecting mosaicism and nuclear organisation in human embryonic nuclei. Panminerva Medica.

[Avian cytogenetics goes functional] Third report on chicken genes and chromosomes 2015

Grffin, D., Romanov, M., O'Connor, R., Fowler, K. and Larkin, D. 2015. [Avian cytogenetics goes functional] Third report on chicken genes and chromosomes 2015. Cytogenetic and Genome Research. 145 (2), pp. 78-179. https://doi.org/10.1159/000430927

20th International Chromosome Conference (ICCXX)

Griffin, D., Fowler, K., Ellis, P. and Jackson, D. 2015. 20th International Chromosome Conference (ICCXX). Chromosome Research. https://doi.org/10.1007/s10577-014-9447-3

Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor

Romanov, M., Farré, M., Lithgow, P., Fowler, K., Skinner, B., O'Connor, R., Fonseka, G., Backström, N., Matsuda, Y., Nishida, C., Houde, P., Jarvis, E., Hanson, E., Burt, D., Larkin, D. and Griffin, D. 2014. Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor. BMC Genomics. 15 (1060). https://doi.org/10.1186/1471-2164-15-1060

Novel approach for deriving genome wide SNP analysis data from archived blood spots

Fowler, K., Reitter, C., Walling, G. and Griffin, D. 2012. Novel approach for deriving genome wide SNP analysis data from archived blood spots. BMC Research Notes. 5 (1), p. 503. https://doi.org/10.1186/1756-0500-5-503

Analyses of pig genomes provide insight into porcine demography and evolution

Groenen, M., Archibald, A., Uenishi, H., Tuggle, C., Takeuchi, Y., Rothschild, M., Rogel-Gaillard, C., Park, C., Milan, D., Megens, H., Li, S., Larkin, D., Kim, H., Frantz, L., Caccamo, M., Ahn, H., Aken, B., Anselmo, A., Anthon, C., Auvil, L., Badaoui, B., Beattie, C., Bendixen, C., Berman, D., Blecha, F., Blomberg, J., Bolund, L., Bosse, M., Botti, S., Bujie, Z., Bystrom, M., Capitanu, B., Carvalho-Silva, D., Chardon, P., Chen, C., Cheng, R., Choi, S., Chow, W., Clark, R., Clee, C., Crooijmans, R., Dawson, H., Dehais, P., De Sapio, F., Dibbits, B., Drou, N., Du, Z., Eversole, K., Fadista, J., Fairley, S., Faraut, T., Faulkner, G., Fowler, K., Fredholm, M., Fritz, E., Gilbert, J., Giuffra, E., Gorodkin, J., Griffin, D., Harrow, J., Hayward, A., Howe, K., Hu, Z., Humphray, S., Hunt, T., Hornshøj, H., Jeon, J., Jern, P., Jones, M., Jurka, J., Kanamori, H., Kapetanovic, R., Kim, J., Kim, J., Kim, K., Kim, T., Larson, G., Lee, K., Lee, K., Leggett, R., Lewin, H., Li, Y., Liu, W., Loveland, J., Lu, Y., Lunney, J., Ma, J., Madsen, O., Mann, K., Matthews, L., McLaren, S., Morozumi, T., Murtaugh, M., Narayan, J., Truong Nguyen, D., Ni, P., Oh, S., Onteru, S., Panitz, F., Park, E., Park, H., Pascal, G., Paudel, Y., Perez-Enciso, M., Ramirez-Gonzalez, R., Reecy, J., Rodriguez-Zas, S., Rohrer, G., Rund, L., Sang, Y., Schachtschneider, K., Schraiber, J., Schwartz, J., Scobie, L., Scott, C., Searle, S., Servin, B., Southey, B., Sperber, G., Stadler, P., Sweedler, J., Tafer, H., Thomsen, B., Wali, R., Wang, J., Wang, J., White, S., Xu, X., Yerle, M., Zhang, G., Zhang, J., Zhang, J., Zhao, S., Rogers, J., Churcher, C. and Schook, L. 2012. Analyses of pig genomes provide insight into porcine demography and evolution. Nature. 491 (7424), pp. 393-398. https://doi.org/10.1038/nature11622

Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis

Skinner, B., Robertson, L., Tempest, H., Langley, E., Ioannou, D., Fowler, K., Crooijmans, R., Hall, A., Griffin, D. and Völker, M. 2009. Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis. BMC Genomics. 10 (1), p. 357. https://doi.org/10.1186/1471-2164-10-357

Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds

Fowler, K., Pong-Wong, R., Bauer, J., Clemente, E., Reitter, C., Affara, N., Waite, S., Walling, G. and Griffin, D. 2013. Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds. BMC Genomics. 14 (1), p. 784. https://doi.org/10.1186/1471-2164-14-784