Ventricular tachyarrhythmia risk in paediatric/young vs. adult Brugada Syndrome patients: A territory-wide study
Journal article
Lee, Sharen, Wong, Wing Tak, Wong, Ian Chi Kei, Mak, Chloe, Mok, Ngai Shing, Liu, Tong and Tse, Gary 2021. Ventricular tachyarrhythmia risk in paediatric/young vs. adult Brugada Syndrome patients: A territory-wide study. Frontiers in Cardiovascular Medicine. 8, p. 671666. https://doi.org/10.3389/fcvm.2021.671666
| Authors | Lee, Sharen, Wong, Wing Tak, Wong, Ian Chi Kei, Mak, Chloe, Mok, Ngai Shing, Liu, Tong and Tse, Gary |
|---|---|
| Abstract | Brugada syndrome (BrS) is a cardiac ion channelopathy with a higher prevalence in Asia compared to the Western populations. The present study compared the differences in clinical and electrocardiographic (ECG) presentation between paediatric/young (≤25 years old) and adult (>25 years) BrS patients. This was a territory-wide retrospective cohort study of consecutive BrS patients presenting to public hospitals in Hong Kong. The primary outcome was spontaneous ventricular tachycardia/ventricular fibrillation (VT/VF). The cohort consists of 550 consecutive patients (median age of initial presentation = 51 ± 23 years; female = 7.3%; follow-up period = 83 ± 80 months), divided into adult ( = 505, mean age of initial presentation = 52 ± 19 years; female = 6.7%; mean follow-up period = 83 ± 80 months) and paediatric/young subgroups ( = 45, mean age of initial presentation = 21 ± 5 years, female = 13.3%, mean follow-up period = 73 ± 83 months). The mean annual VT/VF incidence rate were 17 and 25 cases per 1,000 patient-year, respectively. Multivariate analysis showed that initial presentation of type 1 pattern (HR = 1.80, 95% CI = [1.02, 3.15], = 0.041), initial asymptomatic presentation (HR = 0.26, 95% CI = [0.07, 0.94], = 0.040) and increased P-wave axis (HR = 0.98, 95% CI = [0.96, 1.00], = 0.036) were significant predictors of VT/VF for the adult subgroup. Only initial presentation of VT/VF was predictive (HR = 29.30, 95% CI = [1.75, 492.00], = 0.019) in the paediatric/young subgroup. Clinical and ECG presentation of BrS vary between the paediatric/young and adult population in BrS. Risk stratification and management strategies for younger patients should take into consideration and adopt an individualised approach. [Abstract copyright: Copyright © 2021 Lee, Wong, Wong, Mak, Mok, Liu and Tse.] |
| Keywords | Brugada syndnrome; Paediatric; Risk stratification; Sudden cardiac death; Ventricular arrhythmia |
| Year | 2021 |
| Journal | Frontiers in Cardiovascular Medicine |
| Journal citation | 8, p. 671666 |
| Publisher | Frontiers |
| ISSN | 2297-055X |
| Digital Object Identifier (DOI) | https://doi.org/10.3389/fcvm.2021.671666 |
| Official URL | https://www.frontiersin.org/articles/10.3389/fcvm.2021.671666/full |
| Funder | National Natural Science Foundation of China (81970270 to TL) |
| Publication dates | |
| Online | 11 Jun 2021 |
| Publication process dates | |
| Accepted | 18 May 2021 |
| Deposited | 12 Jul 2021 |
| Publisher's version | License |
| Output status | Published |
| License | http://creativecommons.org/licenses/by/4.0/ |
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https://repository.canterbury.ac.uk/item/8y1w4/ventricular-tachyarrhythmia-risk-in-paediatric-young-vs-adult-brugada-syndrome-patients-a-territory-wide-study
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