The association between blood pressure variability and hip or vertebral fracture risk: A population-based study

Journal article


Zhou, Jiandong, Li, Helen, Chang, Carlin, Wu, William K.K., Wang, Xiansong, Liu, Tong, Cheung, Bernard Man Yung, Zhang, Qingpeng, Lee, Sharen and Tse, Gary 2021. The association between blood pressure variability and hip or vertebral fracture risk: A population-based study. Bone. 150, p. 1160115. https://doi.org/10.1016/j.bone.2021.116015
AuthorsZhou, Jiandong, Li, Helen, Chang, Carlin, Wu, William K.K., Wang, Xiansong, Liu, Tong, Cheung, Bernard Man Yung, Zhang, Qingpeng, Lee, Sharen and Tse, Gary
AbstractBackground The present study evaluated the association between blood pressure variability and the risk of hip/vertebral fractures in middle aged and elderly patients. Methods This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st December 2003 and were followed up until 31st December 2019. Standard deviation (SD), root mean square (RMS), coefficient of variation (CV) and a variability score (defined as the number of changes in blood pressure (diastolic and systolic) of 5 mmHg or more) were used as measures of blood pressure variability. The primary outcome was a composite of new onset hip or vertebral fractures. Results A total of 57,810 patients were included. Over a median follow-up of 5894 days (interquartile range: 3505–6487), 3285 patients (5.68%) developed new onset hip/vertebral fractures. The crude incidence rates were 4.95%, 5.31%, and 7.2% for diastolic blood pressure-CV and 5.0%, 5.28%, and 7.08% for systolic blood pressure-CV in the first, second, and third tertiles, respectively. Survival analysis demonstrated differences in hip/vertebral fracture amongst the tertiles of systolic and diastolic blood pressure variability (P < 0.0001). Conclusions Measures of blood pressure variability were significantly associated with incident hip/vertebral fractures. They can be incorporated into existing clinical scores to improve risk stratification.
KeywordsBlood pressure; Fracture risk
Year2021
JournalBone
Journal citation150, p. 1160115
PublisherElsevier
ISSN8756-3282
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bone.2021.116015
Official URLhttps://doi.org/10.1016/j.bone.2021.116015
Publication dates
Online23 May 2021
Publication process dates
Accepted12 May 2021
Deposited26 May 2021
Accepted author manuscript
License
Output statusPublished
Page range116015
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