Powerful proteins from polyp possessing predators

Book chapter


Robinson P.J., Trim, S.A. and Trim, C.M. 2021. Powerful proteins from polyp possessing predators. in: Mariottini, G.L., Killi, N. and Xiao, L. (ed.) The Cnidaria: only a problem or also a source Nova Science Publishers.
AuthorsRobinson P.J., Trim, S.A. and Trim, C.M.
EditorsMariottini, G.L., Killi, N. and Xiao, L.
Abstract

Cnidarians are soft bodied animals possessing complex venom systems which have evolved to allow for the capture of arthropod and vertebrate prey, as well as to defend themselves against such predators. The effects of these venoms on humans, as a result of envenomation, has been studied for many decades, whereas the possibility of using these proteins to fight human disease is in its infancy. Drug discovery utilisation of Cnidarian venoms has been hampered by availability of animals and suitable extraction techniques that allow for study of such protein toxins. Studies of toxins that have been suitably purified for drug discovery have, by in large, only investigated target engagement and negated to investigate other drug like properties such as absorption, dispersion, metabolism, and excretion (ADME). This chapter will review the sourcing of Cnidaria for drug discovery, extraction of venom components, actions of venoms on drug relevant targets and their suitability as drug like molecules.

KeywordsCnidarian; Venom; ADME; Drug discover; Extraction techniques
Year2021
Book titleThe Cnidaria: only a problem or also a source
PublisherNova Science Publishers
Output statusIn press
File
Publication process dates
Accepted26 Nov 2020
Deposited04 Jan 2021
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