Progenitor cells in auricular cartilage demonstrate promising cartilage regenerative potential in 3D hydrogel culture

Conference poster


Otto, I. A, Levatto, R., Webb, R., Khan I. M., Breugem, C.C. and Malda, J. 2017. Progenitor cells in auricular cartilage demonstrate promising cartilage regenerative potential in 3D hydrogel culture.
AuthorsOtto, I. A, Levatto, R., Webb, R., Khan I. M., Breugem, C.C. and Malda, J.
TypeConference poster
Description

The reconstruction of auricular deformities is a very challenging surgical procedure that could benefit from a tissue engineering approach. Nevertheless, a major obstacle is presented by the acquisition of sufficient amounts of autologous cells to create a cartilage construct the size of the human ear. Extensively expanded chondrocytes are unable to retain their phenotype, while bone marrow-derived mesenchymal stromal cells (MSC) show endochondral terminal differentiation by formation of a calcified matrix. The identification of tissue-specific progenitor cells in auricular cartilage, which can be expanded to high numbers without loss of cartilage phenotype, has great prospects for cartilage regeneration of larger constructs. This study investigates the largely unexplored potential of auricular progenitor cells for cartilage tissue engineering in 3D hydrogels.

KeywordsAuricular deformaties
Year2017
ConferenceTERMIS-EU 2017
Official URLhttps://ecmconferences.org/abstracts/2017/Collection2/TERMIS_2017.html
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File Access Level
Open
Publication process dates
Deposited13 Jul 2020
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https://repository.canterbury.ac.uk/item/8vxw1/progenitor-cells-in-auricular-cartilage-demonstrate-promising-cartilage-regenerative-potential-in-3d-hydrogel-culture

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