Microbial adaptation to venom is common in snakes and spiders

Journal article


Esmaeilishirazifard, E., Usher, L., Trim, C., Denise, H., Sangal, V., Tyson, G., Barlow, A., Redway, K., Taylor, J., Kremyda-Vlachou, M., Loftus, T., Lock, M., Wright, K., Dalby, A., Snyder, L., Wuster, W., Trim, S. and Moschos, S. 2018. Microbial adaptation to venom is common in snakes and spiders. bioRxiv. https://doi.org/10.1101/348433v1
AuthorsEsmaeilishirazifard, E., Usher, L., Trim, C., Denise, H., Sangal, V., Tyson, G., Barlow, A., Redway, K., Taylor, J., Kremyda-Vlachou, M., Loftus, T., Lock, M., Wright, K., Dalby, A., Snyder, L., Wuster, W., Trim, S. and Moschos, S.
Abstract

Animal venoms are considered sterile sources of antimicrobial compounds with strong membrane disrupting activity against multi-drug resistant bacteria. However, bite wound infections are common in developing nations. Investigating the oral and venom microbiome of five snake and two spider species, we evidence viable microorganisms potentially unique to venom for black-necked spitting cobras (Naja nigricollis). Among these are two novel sequence types of Enterococcus faecalis misidentified by commonly used clinical biochemistry procedures as Staphylococcus; the genome sequence data of venom-specific isolates feature an additional 45 genes, at least 11 of which improve membrane integrity. Our findings challenge the dogma of venom sterility and indicate an increased primary infection risk in the clinical management of venomous animal bite wounds.

Year2018
JournalbioRxiv
PublisherCold Spring Harbor Laboratory
Digital Object Identifier (DOI)https://doi.org/10.1101/348433v1
Official URLhttps://www.biorxiv.org/content/10.1101/348433v1
FunderUniversity of Westminster
University of Northumbria
Venomtech Ltd
Publication process dates
Deposited19 Jul 2019
Completed16 Jun 2018
Accepted author manuscript
Output statusUnpublished
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https://repository.canterbury.ac.uk/item/8905v/microbial-adaptation-to-venom-is-common-in-snakes-and-spiders

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