Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans
Wang, Y., Kammenga, J. and Harvey, S. 2017. Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans. Human Genomics. 11 (1). https://doi.org/10.1186/s40246-017-0108-4
|Authors||Wang, Y., Kammenga, J. and Harvey, S.|
Background: Neurodegenerative diseases (NGDs) such as Alzheimer’s and Parkinson’s are debilitating and largely untreatable conditions strongly linked to age. The clinical, neuropathological, and genetic components of NGDs indicate that neurodegeneration is a complex trait determined by multiple genes and by the environment.
Main body: The symptoms of NGDs differ among individuals due to their genetic background, and this variation affects the onset and progression of NGD and NGD-like states. Such genetic variation affects the molecular and cellular processes underlying NGDs, leading to differential clinical phenotypes. So far, we have a limited understanding of the mechanisms of individual background variation. Here, we consider how variation between genetic backgrounds affects the mechanisms of aging and proteostasis in NGD phenotypes. We discuss how the nematode Caenorhabditis elegans can be used to identify the role of variation between genetic backgrounds.Additionally, we review advance s in C. elegans methods that can facilitate the identification of NGD regulators and/or networks.
Conclusion: Genetic variation both in disease genes and in regulatory factors that modulate onset and progression of NGDs are incompletely understood. The nematode C. elegans represents a valuable system in which to address such questions.
|Journal citation||11 (1)|
|Digital Object Identifier (DOI)||https://doi.org/10.1186/s40246-017-0108-4|
|Human Frontiers Science Program|
|25 May 2017|
|Publication process dates|
|Deposited||30 May 2017|
|Accepted||12 May 2017|
Open Access journal
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