Computerized structured cognitive training in patients affected by early-stage Alzheimer’s disease is feasible and effective: a randomized controlled study
Cavallo, M., Hunter, M., van der Hiele, K. and Angilletta, C. 2016. Computerized structured cognitive training in patients affected by early-stage Alzheimer’s disease is feasible and effective: a randomized controlled study. Archives of Clinical Neuropsychology. 31 (8), pp. 868-876. https://doi.org/10.1093/arclin/acw072
|Authors||Cavallo, M., Hunter, M., van der Hiele, K. and Angilletta, C.|
Introduction. Alzheimer’s disease (AD) presents with significant neuropsychological deficits. Cognitive training in AD has recently started to demonstrate its efficacy. In this study we implemented computerized cognitive training of a large group of early-stage AD patients, to identify its effects at a neuropsychological level and to investigate whether they were stable after 6 months.
Results. A Repeated Measures General Linear Model considering groups’ performance at the three assessment points (before training, after training, and at the 6-month follow-up) showed a significant interaction effect for: digit span forward (F(2,74) = 2.785, p = 0.03) and backward (F(2,74) = 3.183, p = 0.02), two-syllable words test (F(2,74) = 3.491, p = 0.004), Rivermead Behavioural Memory Test immediate (F(2,74) = 2.877, p = 0.03) and delayed (F(2,74) = 3.783, p = 0.003), Token test (F(2,74) = 4.783, p = 0.001), and Brixton test (F(2,74) = 8.783, p < 0.001). For all of them, experimental group performed better than controls.
|Journal||Archives of Clinical Neuropsychology|
|Journal citation||31 (8), pp. 868-876|
|Publisher||Oxford University Press|
|Digital Object Identifier (DOI)||https://doi.org/10.1093/arclin/acw072|
|24 Nov 2016|
|Publication process dates|
|Deposited||05 Jan 2017|
|Accepted||11 Aug 2016|
|Accepted author manuscript|
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