The role of endoproteolytic processing in neurodegeneration
Journal article
Wilson, C., Mushtaq, G., Kamal, M. and Terro, F. 2016. The role of endoproteolytic processing in neurodegeneration. CNS and Neurological Disorders Drug Targets. 15. https://doi.org/10.2174/1871527315666160922163511
Authors | Wilson, C., Mushtaq, G., Kamal, M. and Terro, F. |
---|---|
Abstract | Endoproteolysis is a normal post-translational process in the eukaryotic cell that had played a role early on in protein evolution allowing protein catabolism and the generation of amino acids. Endoproteolytic cleavage regulates many crucial cellular processes including the activity of many proteins, their protein-protein interactions and the amplification of cell signals. Not surprisingly, disruption or alternation of endoproteolytic cleavage maybe the root cause of many human diseases such as Alzheimer’s disease, Huntington’s disease and prion diseases. Most neurodegenerative diseases (ND) are caused by the build-up of misfolded proteins and the promotion of aggregation events. A common event that occurs in these ND is the alteration of endoproteolytic cleavage due to genetic mutations of the associated-proteases or in the target substrate. Endoproteolytic cleavage resulting in protein truncation has significant effects on the structure and function of a protein representing a common feature of ND. In this review, we will discuss the endoproteolytic cleavage events that lead to ND, namely Alzheimer’s disease, Huntington’s disease and prion diseases. |
Year | 2016 |
Journal | CNS and Neurological Disorders Drug Targets |
Journal citation | 15 |
Publisher | Bentham Science Publishers |
ISSN | 1871-5273 |
Digital Object Identifier (DOI) | https://doi.org/10.2174/1871527315666160922163511 |
Publication dates | |
Online | 22 Sep 2016 |
Publication process dates | |
Deposited | 21 Sep 2016 |
Completed | 31 Jan 2016 |
Accepted | 21 Sep 2016 |
Accepted author manuscript | |
Output status | Published |
https://repository.canterbury.ac.uk/item/87wzx/the-role-of-endoproteolytic-processing-in-neurodegeneration
Download files
86
total views151
total downloads0
views this month0
downloads this month