Expanding the view on the evolution of the nematode dauer signalling pathways: refinement through gene gain and pathway co-option

Journal article

Gilabert, A., Curran, D., Harvey, S. and Wasmuth, J. 2016. Expanding the view on the evolution of the nematode dauer signalling pathways: refinement through gene gain and pathway co-option. BMC Genomics. 17, p. 476. https://doi.org/10.1186/s12864-016-2770-7

Publication dates
Authors	Gilabert, A., Curran, D., Harvey, S. and Wasmuth, J.
Abstract	Background Signalling pathways underlie development, behaviour and pathology. To understand patterns in the evolution of signalling pathways, we undertook a comprehensive investigation of the pathways that control the switch between growth and developmentally quiescent dauer in 24 species of nematodes spanning the phylum. Results Our analysis of 47 genes across these species indicates that the pathways and their interactions are not conserved throughout the Nematoda. For example, the TGF-β pathway was co-opted into dauer control relatively late in a lineage that led to the model species Caenorhabditis elegans. We show molecular adaptations described in C. elegans that are restricted to its genus or even just to the species. Similarly, our analyses both identify species where particular genes have been lost and situations where apparently incorrect orthologues have been identified. Conclusions Our analysis also highlights the difficulties of working with genome sequences from non-model species as reliance on the published gene models would have significantly restricted our understanding of how signalling pathways evolve. Our approach therefore offers a robust standard operating procedure for genomic comparisons.
Year	2016
Journal	BMC Genomics
Journal citation	17, p. 476
Publisher	BioMed Central
ISSN	1471-2164
Digital Object Identifier (DOI)	https://doi.org/10.1186/s12864-016-2770-7
Print	27 Jun 2016
Publication process dates
Deposited	30 Jun 2016
Accepted	25 May 2016
Output status	Published
Additional information	Open Access Journal

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