A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates

Journal article


Bressington, D., Stock, J., Hulbert, S. and MacInnes, D. 2015. A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates. International Clinical Psychopharmacology. 30 (4), pp. 230-236. https://doi.org/10.1097/YIC.0000000000000077
AuthorsBressington, D., Stock, J., Hulbert, S. and MacInnes, D.
Abstract

This retrospective mirror-image observational study aimed to establish the effects of the long-acting antipsychotic injection paliperidone palmitate (PP) on acute inpatient hospitalization rates. We utilized routinely collected clinical data to compare the number and length of acute patient admissions 1 year before and 1 year after initiation of PP. A single cohort of 66 patients with a diagnosis of schizophrenia and who had received monthly injections of PP for at least 1 year were included in the analysis. The mean number of acute inpatient admissions fell from 0.86 in the year before PP initiation to 0.23 in the following year (P=0.001), and there was a numerical but nonsignificant decrease in the number of bed days from 32.48 to 31.22 over the study duration. The median number of bed days in the year before PP initiation was 20, and in the year after initiation it was 0. The median number of admissions also fell from 1 to 0 during the same period. The results of the study should be treated cautiously because of the limitations of the study design but suggest that patients with a diagnosis of schizophrenia who continue treatment with PP over 12 months experience a significant reduction in hospital admissions compared with the previous year.

Year2015
JournalInternational Clinical Psychopharmacology
Journal citation30 (4), pp. 230-236
PublisherLippincott, Williams and Wilkins
ISSN0268-1315
Digital Object Identifier (DOI)https://doi.org/10.1097/YIC.0000000000000077
Publication dates
PrintJul 2015
Publication process dates
Deposited07 Jan 2016
Accepted11 Jan 2015
Output statusPublished
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Strengthening healthcare communities through knowledge exchange
Jones, F. and MacInnes, D. 2013. Strengthening healthcare communities through knowledge exchange.
The effects of training mental health practitioners in medication management to address nonadherence: a systematic review of clinician-related outcomes
Bressington, D., Coren, E. and MacInnes, D. 2013. The effects of training mental health practitioners in medication management to address nonadherence: a systematic review of clinician-related outcomes. Nursing: Research and Reviews. 3, pp. 87-98. https://doi.org/10.2147/NRR.S44366
Service-user involvement in forensic mental health care research: areas to consider when developing a collaborative study
MacInnes, D., Beer, D., Keeble, P., Rees, D. and Reid, L. 2011. Service-user involvement in forensic mental health care research: areas to consider when developing a collaborative study. Journal of Mental Health. 20 (5), pp. 464-472. https://doi.org/10.3109/09638231003728109
Risk prevention and non-pharmacological management of violence in the acute setting
MacInnes, D., Patel, S., Olumoroti, J. and McAllister, R. 2013. Risk prevention and non-pharmacological management of violence in the acute setting. in: Khwaja, M. and Beer, D. (ed.) Prevention and Management of Violence: Guidance for Mental Healthcare Professionals London RCPsych Publications.
The influence of parents' education in the Italian standardization sample of the WISC-III
Cianci, L., Orsini, A., Hulbert, S. and Pezzuti, L. 2013. The influence of parents' education in the Italian standardization sample of the WISC-III. Learning and Individual Differences. 28, pp. 47-53. https://doi.org/10.1016/j.lindif.2013.09.009
Why now is the time to invest in e-health technologies
De Weger, E., Jones, F., MacInnes, D., Enser, J. and Francis, S. 2012. Why now is the time to invest in e-health technologies. Health Service Journal [Resource Centre].
Implementing video conferencing in mental health practice
De Weger, E., MacInnes, D., Enser, J., Francis, S. and Jones, F. 2012. Implementing video conferencing in mental health practice. Journal of Psychiatric and Mental Health Nursing. https://doi.org/10.1111/j.1365-2850.2012.01947.x
The development of a questionnaire to measure in-patient satisfaction with forensic services - the Forensic Satisfaction Scale
MacInnes, D., Beer, D., Keeble, P., Rees, D. and Reid, L. 2006. The development of a questionnaire to measure in-patient satisfaction with forensic services - the Forensic Satisfaction Scale. Liverpool
Risk assessment in mental illness
MacInnes, D. 2000. Risk assessment in mental illness. London EMAP Healthcare.
A case study exploration of the value of acupuncture as an adjunct treatment for patients diagnosed with schizophrenia: results and future study design
Ronan, P., Robinson, N., Harbinson, D. and MacInnes, D. 2011. A case study exploration of the value of acupuncture as an adjunct treatment for patients diagnosed with schizophrenia: results and future study design. Zhong xi yi jie he xue bao = Journal of Chinese Integrative Medicine. 9 (5), pp. 503-514. https://doi.org/10.3736/jcim20110507
The development of a Carer Support Worker service in forensic inpatient mental health settings
MacInnes, D. and Bressington, D. 2011. The development of a Carer Support Worker service in forensic inpatient mental health settings.
Factors associated with antipsychotic medication adherence in community based patients with schizophrenia in Hong Kong: a cross sectional study
Bressington, D., Mui, J. and Gray, R. 2011. Factors associated with antipsychotic medication adherence in community based patients with schizophrenia in Hong Kong: a cross sectional study.
The road less travelled: preparing research supervisors in an interprofessional context
Brown, M., Clark, T. and MacInnes, D. 2008. The road less travelled: preparing research supervisors in an interprofessional context.
Pre-registration nurse training in the UK
Bressington, D. 2009. Pre-registration nurse training in the UK.
Medication management
Bressington, D. and Gray, R. 2009. Medication management.
Approved mental health professional training evaluation
Bressington, D., Wells, H. and Graham, M. 2009. Approved mental health professional training evaluation.
Improving health behaviours
Bressington, D. 2009. Improving health behaviours.
Enhancing adherence with treatment
Bressington, D. 2009. Enhancing adherence with treatment.
A concept mapping exploration of social workers' and mental health nurses' understanding of the role of the approved mental health professional
Bressington, D. and Wells, H. 2010. A concept mapping exploration of social workers' and mental health nurses' understanding of the role of the approved mental health professional.
Review of breaches of security in a low secure mental health unit
MacInnes, D. 2009. Review of breaches of security in a low secure mental health unit. Oxleas NHS Foundation Trust.
Caregivers support within forensic mental health services: A multi-site evaluation
MacInnes, D. 2009. Caregivers support within forensic mental health services: A multi-site evaluation. Kent and Medway Partnership Trust and Oxleas NHS Foundation Trust.
What are the reasons for the publication or non-publication of nursing research?
MacInnes, D., Ashmore, R., Banks, D. and Flanagan, T. 2009. What are the reasons for the publication or non-publication of nursing research?
The illness beliefs of caregivers of the mentally ill
MacInnes, D. 2000. The illness beliefs of caregivers of the mentally ill.
The development of an assessment of caregiver burden
MacInnes, D. 1999. The development of an assessment of caregiver burden.
Ethical issues in clinical research
MacInnes, D. 1999. Ethical issues in clinical research. London NT Books.
Using a Delphi approach to ascertain what factors influence the publication of mental health nursing research
MacInnes, D., Ashmore, R., Banks, D. and Flanagan, T. 2007. Using a Delphi approach to ascertain what factors influence the publication of mental health nursing research.
Levels of service user satisfaction in secure settings – A survey of the association between perceived social climate, perceived therapeutic relationship and satisfaction with forensic services
Bressington, D., Stewart, B., Beer, D. and MacInnes, D. 2011. Levels of service user satisfaction in secure settings – A survey of the association between perceived social climate, perceived therapeutic relationship and satisfaction with forensic services. International Journal of Nursing Studies. 48 (11), pp. 1349-1356. https://doi.org/10.1016/j.ijnurstu.2011.05.011
Medication management for people with a diagnosis of schizophrenia
Gray, R., Robson, D. and Bressington, D. 2002. Medication management for people with a diagnosis of schizophrenia. Nursing Times. 98 (47), pp. 38-40.
Psychopharmacology and medication management
Gray, R., Brewin, E. and Bressington, D. 2003. Psychopharmacology and medication management. in: Coffey, M. and Hannigan, B. (ed.) The Handbook of Community Mental Health Nursing Abingdon, UK Routledge. pp. 274-286
Enhancing medical adherence
Bressington, D. 2007. Enhancing medical adherence. in: Taylor, D., Paton, C. and Kerwin, R. (ed.) The Maudsley Prescribing Guidelines Informa Healthcare. pp. 512-514
Acupuncture and schizophrenia - effect and acceptability: preliminary results of the first UK study
Ronan, P., Harbinson, D., MacInnes, D., Lewis, W. and Robinson, N. 2010. Acupuncture and schizophrenia - effect and acceptability: preliminary results of the first UK study. European Journal of Oriental Medicine. 6 (5), pp. 19-31.
A concept mapping exploration of social workers' and mental health nurses' understanding of the role of the Approved Mental Health Professional
Bressington, D., Wells, H. and Graham, M. 2011. A concept mapping exploration of social workers' and mental health nurses' understanding of the role of the Approved Mental Health Professional. Nurse Education Today. 31 (6), pp. 564-570. https://doi.org/10.1016/j.nedt.2010.10.034
Risk assessment in mental health
MacInnes, D. 1998. Risk assessment in mental health.
Attribution theory
MacInnes, D. 1998. Attribution theory. Mental Health Occupational Therapy Magazine. 3, pp. 35-36.
Understanding systemic reviews
MacInnes, D. 2009. Understanding systemic reviews. British Journal of Cardiac Nursing. 4 (7), pp. 331-334.
Report of the committee of inquiry into current care and treatment practices in the central mental hospital
Parrott, J., Casey, T., Finnerty, S., MacInnes, D. and McMorrow, D. 2007. Report of the committee of inquiry into current care and treatment practices in the central mental hospital. Mental Health Commission.
Relatives and informal caregivers
MacInnes, D. 2000. Relatives and informal caregivers. in: Chaloner, C. and Coffey, M. (ed.) Forensic Mental Health Nursing: Current Approaches Oxford Blackwell Science. pp. 208-231
The nurse as researcher
MacInnes, D. 2001. The nurse as researcher. in: Forster, S. (ed.) The Role of the Mental Health Nurse Cheltenham Nelson Thornes. pp. 160-181
The nurse as therapist and counsellor
MacInnes, D., MacDonald, N. and Morrissey, M. 2001. The nurse as therapist and counsellor. in: Forster, S. (ed.) The Role of the Mental Health Nurse Cheltenham Nelson Thornes. pp. 64-91
Advancing practice in family nursing across the cancer continuum
Flanagan, J., Holmes, S. and MacInnes, D. 2002. Advancing practice in family nursing across the cancer continuum. in: Clarke, D., Flanagan, J. and Kendrick, K. (ed.) Advancing Nursing Practice in Cancer and Palliative Care Basingstoke Palgrave Macmillan. pp. 117-139
Relatives and carers of clients with schizophrenia
MacInnes, D. 1996. Relatives and carers of clients with schizophrenia. Mental Health Occupational Therapy Magazine. 1 (1), pp. 16-21.
Illness representations: a way forward in developing therapeutic interventions
MacInnes, D. 1998. Illness representations: a way forward in developing therapeutic interventions. Mental Health Occupational Therapy Magazine. 3 (1), pp. 13-18.
The differences between health professionals in assessing levels of caregiver burden
MacInnes, D. 1998. The differences between health professionals in assessing levels of caregiver burden. Journal of Psychiatric and Mental Health Nursing. 5 (4), pp. 265-271. https://doi.org/10.1046/j.1365-2850.1998.00135.x
The relationship between building design and escapes from secure units
Enser, J. and MacInnes, D. 1999. The relationship between building design and escapes from secure units. The Journal of the Royal Society for the Promotion of Health. 119 (3), pp. 170-174. https://doi.org/10.1177/146642409911900307
Interventions in forensic psychiatry: the caregivers perspective
MacInnes, D. 2000. Interventions in forensic psychiatry: the caregivers perspective. British Journal of Nursing. 9 (15), pp. 992-998.
Nursing in prisons - past, present and future
MacInnes, D. 2000. Nursing in prisons - past, present and future. Health Matters in Prisons. 5 (1), pp. 14-20.
The differences in perceived burdens between forensic and non-forensic caregivers of individuals suffering from schizophrenia
MacInnes, D. and Watson, J. 2002. The differences in perceived burdens between forensic and non-forensic caregivers of individuals suffering from schizophrenia. Journal of Mental Health. 11 (4), pp. 375-388. https://doi.org/10.1080/09638230020023741
Evaluating an assessment scale of irrational beliefs for people with mental health problems
MacInnes, D. 2003. Evaluating an assessment scale of irrational beliefs for people with mental health problems. Nurse Researcher. 10 (4), pp. 53-67.
Contributors to stress among prison service staff
Holmes, S. and MacInnes, D. 2003. Contributors to stress among prison service staff. British Journal of Forensic Practice. 5 (2), pp. 16-24.
The theories underpinning rational emotive behaviour therapy: where's the supportive evidence?
MacInnes, D. 2004. The theories underpinning rational emotive behaviour therapy: where's the supportive evidence? International Journal of Nursing Studies. 41 (6), pp. 685-695. https://doi.org/10.1016/j.ijnurstu.2004.02.004
The development of a tool to measure service user satisfaction with in-patient forensic services: The Forensic Satisfaction Scale
MacInnes, D., Beer, D., Keeble, P., Rees, D. and Reid, L. 2010. The development of a tool to measure service user satisfaction with in-patient forensic services: The Forensic Satisfaction Scale. Journal of Mental Health. 19 (3), pp. 272-281. https://doi.org/10.3109/09638231003728133
Self-esteem and self-acceptance: an examination into their relationship and their effect on psychological health
MacInnes, D. 2006. Self-esteem and self-acceptance: an examination into their relationship and their effect on psychological health. Journal of Psychiatric and Mental Health Nursing. 13 (5), pp. 483-489.
The evaluation of a short group programme to reduce self-stigma in people with serious and enduring mental health problems
MacInnes, D. and Lewis, M. 2008. The evaluation of a short group programme to reduce self-stigma in people with serious and enduring mental health problems. Journal of Psychiatric and Mental Health Nursing. 15 (1), pp. 59-65. https://doi.org/10.1111/j.1365-2850.2007.01212.x
Interventions in forensic psychiatry: the caregiver's perspective
MacInnes, D. 2000. Interventions in forensic psychiatry: the caregiver's perspective. British Journal of Nursing. 9 (15), pp. 992-8.