Identification of surrogate markers for determining drug activity using proteomics

Journal article


McClelland, C. and Gullick, W. 2003. Identification of surrogate markers for determining drug activity using proteomics. Biochemical Society Transactions. 31 (6), pp. 1488-1490. https://doi.org/10.1042/bst0311488
AuthorsMcClelland, C. and Gullick, W.
Abstract

In a high proportion of human carcinomas overexpression of the EGFR (epidermal growth factor receptor), a receptor tyrosine kinase, represents a potential target for cancer treatment. EGFR is induced to dimerize through ligand binding which activates the tyrosine kinase activity of the receptor. This catalyses the transfer of ATP's gamma-phosphate to hydroxyl groups of tyrosine residues on the receptor, creating binding sites that recruit downstream signalling proteins. New drugs, SMTKIs (small-molecule tyrosine kinase inhibitors), have been designed to inhibit the tyrosine kinase activity of the receptor, producing an anti-tumour effect. The development of surrogate markers to determine the drug activity of these new inhibitors would be of great benefit in drug evaluation and in the subsequent management of patient disease. This review describes current treatments of cancer using tyrosine kinase inhibitors and the use of proteomic analysis to identify possible markers of activity of these new drugs.

Year2003
JournalBiochemical Society Transactions
Journal citation31 (6), pp. 1488-1490
PublisherPortland Press
ISSN0300-5127
Digital Object Identifier (DOI)https://doi.org/10.1042/bst0311488
Publication process dates
Deposited15 Jul 2015
Accepted01 Dec 2003
Accepted2003
Output statusPublished
Permalink -

https://repository.canterbury.ac.uk/item/8762y/identification-of-surrogate-markers-for-determining-drug-activity-using-proteomics

  • 4
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Utilisation of compounds from venoms in drug discovery
Trim, C., Byrne, L. and Trim, S. 2021. Utilisation of compounds from venoms in drug discovery. in: Witty, D.R. (ed.) Progress in medicinal chemistry volume 60 Elsevier.
Powerful proteins from polyp possessing predators
Robinson P.J., Trim, S.A. and Trim, C.M. 2021. Powerful proteins from polyp possessing predators. in: Mariottini, G.L., Killi, N. and Xiao, L. (ed.) The Cnidaria: only a problem or also a source Nova Science Publishers.
Beauty from the deep: cnidarians in cosmetics
Trim, S.A., Wandrey, F and Trim, C.M. 2021. Beauty from the deep: cnidarians in cosmetics. in: Mariottini, G.L., Killi, N. and Xiao, L. (ed.) The Cnidaria: Only a problem or also a source Nova Science Publishers.
Full spectrum lighting induces behavioral changes and increases cortisol immunoreactivity in captive arachnids
Somerville, S., Baker, S., Baines, F., Trim, S. and Trim, C.M. 2020. Full spectrum lighting induces behavioral changes and increases cortisol immunoreactivity in captive arachnids. Journal of Applied Animal Welfare Science. https://doi.org/10.1080/10888705.2021.1872027
The failures of ethnobotany and phytomedicine in delivering novel treatments for snakebite envenomation
Trim, S., Trim, C., Williams, H. F. and Vaiyapuri, S. 2020. The failures of ethnobotany and phytomedicine in delivering novel treatments for snakebite envenomation. Toxins. 12 (12). https://doi.org/10.3390/toxins12120774
Kinome scale profiling of venom effects on cancer cells reveals potential new venom activities
Mccullough, D., Atofanei, C., Knight, E., Trim, S. and Trim, C.M. 2020. Kinome scale profiling of venom effects on cancer cells reveals potential new venom activities. Toxicon. 185, pp. 129-146. https://doi.org/10.1016/j.toxicon.2020.07.007
Microbial adaptation to venom is common in snakes and spiders
Esmaeilishirazifard, E., Usher, L., Trim, C., Denise, H., Sangal, V., Tyson, G., Barlow, A., Redway, K., Taylor, J., Kremyda-Vlachou, M., Loftus, T., Lock, M., Wright, K., Dalby, A., Snyder, L., Wuster, W., Trim, S. and Moschos, S. 2018. Microbial adaptation to venom is common in snakes and spiders. bioRxiv. https://doi.org/10.1101/348433v1
Transitioning novel peptide hits into lead compounds
Trim, S. and Trim, C. 2019. Transitioning novel peptide hits into lead compounds. Drug Target Review. (4).
Non-invasive extraction of Cnidarian venom through the use of autotomised tentacles
Robinson, P., Trim, S. and Trim, C. 2019. Non-invasive extraction of Cnidarian venom through the use of autotomised tentacles. Animal Technology and Welfare. 18 (3).
Rapid method for targeted cell (line) selection
Lang, D., Martin, E., Montague, G., O'Malley, C., Root, T., Trim, C., Povey, J., Smales, C. and Racher, A. 2012. Rapid method for targeted cell (line) selection.
Localisation of Neuregulin 1-β3 to different sub-nuclear structures alters gene expression
Wang, M., Trim, C. and Gullick, W. 2011. Localisation of Neuregulin 1-β3 to different sub-nuclear structures alters gene expression. Experimental Cell Research. 317 (4), pp. 423-432. https://doi.org/10.1016/j.yexcr.2010.11.009.
Venom: The sharp end of pain therapy
Trim, S. and Trim, C. 2013. Venom: The sharp end of pain therapy. British Journal of Pain. 7 (4), pp. 179-188. https://doi.org/10.1177/2049463713502005
Novel approaches to targeting protein tyrosine kinases
McCullough, D. and Trim, C. 2015. Novel approaches to targeting protein tyrosine kinases. Drug Target Review.
Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling
Povey, J., O'Malley, C., Root, T., Martin, E., Montague, G., Feary, M., Trim, C., Lang, D., Aldread, R., Racher, A. and Smales, C. 2014. Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling. Journal of Biotechnology. 184, pp. 84-93. https://doi.org/10.1016/j.jbiotec.2014.04.028
Neuregulins in the nucleus
McClelland, C. and Gullick, W. 2009. Neuregulins in the nucleus. in: Giordano, A. and Normanno, N. (ed.) Breast Cancer In the Post-Genomic Era Springer. pp. 79-86
Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity
McClelland, C. and Gullick, W. 2007. Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity. British Journal of Cancer. 96 (2), pp. 284-289. https://doi.org/10.1038/sj.bjc.6603544
99mTc-SnF2 colloid “LLK”: particle size, morphology, and leukocyte labelling behaviour
McClelland, C., Onuegbulem, E., Carter, N., Leahy, M., O'Doherty, M., Pooley, F., O'Doherty, T., Newsam, R., Ensing, G. and Blower, P. 2003. 99mTc-SnF2 colloid “LLK”: particle size, morphology, and leukocyte labelling behaviour. Nuclear Medicine Communications. 24 (2), pp. 191-202. https://doi.org/10.1097/01.mnm.0000057333.59072.1c